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Research on the challenges and improvements of the roller compaction process for dry granulation
- 1 University of Washington, Seattle
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Abstract
The analysis of the challenges for roller compaction (RC) in the dry granulation (DG) pharmaceutical industry process and their relative improvements are presented based on the review of previous research done by others. According to research between the 2000s and 2010s, magnifying the benefit that already obtains has been the main improvement of RC, such as increasing production efficiency and stability. Although modifications also reduced some of the disadvantages, such as reducing the use of raw material and waste, these improvements are still too limited, and some serious limitations still hindered the application of RC: the three major issues were: the large number of fragments producing, relatively fragile tablet, and the easy breaking ribbon. However, some research that took place later quickly fixed the limitation and make RC more applicable. This review briefly summarizes the issues that exist in the RC process, the improvements that have already been done to improve RC, and the limitations that RC still has.
Keywords
dry granulation, roller compaction, pharmaceutical industry, improvement
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Cite this article
Shen,S. (2023). Research on the challenges and improvements of the roller compaction process for dry granulation. Applied and Computational Engineering,7,677-684.
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Volume title: Proceedings of the 3rd International Conference on Materials Chemistry and Environmental Engineering (CONF-MCEE 2023), Part II
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