Retrosynthetic analysis is a sea change in methodical design of synthesis routes to complex molecules in organic chemistry. The brainchild of Nobel laureate Elias James Corey, this approach-in essence-inverts the convention in synthesis by working one's way backward from the target molecule to simpler, more accessible precursors. Basic concepts like the process of disconnections and synthons, functional group interconversions are basic concepts that form a basis of deconstruction of molecules into manageable pieces. Retrosynthetic analysis has found wide applications in pharmaceuticals, natural product synthesis, and materials chemistry, offering ways of effective solutioning in the manufacturing of active pharmaceutical ingredients, biologically active compounds, and advanced materials. Although some problems concerning molecule complexity and scalability of reactions do arise, this method remains irreplaceable in the process of driving innovation in chemical synthesis. Further evolution of retrosynthesis with state-of-the-art computational tools along with sustainable practices will continue to advance the field of organic chemistry. This article contextualizes retrosynthetic analysis in depth: describing its principles, application, challenges, and prospects of implementation by academic and industrial circles.

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Using Sentinel satellite data, particularly the red-edge bands and shortwave infrared bands that are sensitive to vegetation, we addressed the lack of research on extracting post-disaster burn scars by selecting Sentinel-2 satellite data before and after the forest fire on April 23, 2020, in Xiaozhushan, Qingdao, Shandong Province. Different extraction methods were employed to explore the potential of identifying burn scars, and a comparative study was conducted. The experimental results indicated that NBR2 was the least affected by smoke and achieved the highest extraction accuracy. The other methods were relatively more affected by smoke. The supervised classification method could effectively avoid the influence of water body changes. The study demonstrated that among various methods, NBR2 could accurately extract burn scars quickly and with high precision.

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With the continuous growth of world energy demand and the rapid development of energy storage technology, adding energy storage systems to power systems to improve energy utilization efficiency and reduce energy waste caused by sustainable energy volatility will be a common form in the future. Optimizing energy scheduling is the key to improving system efficiency and economy. This paper proposes a wind, PV, thermal and hydrogen energy storage combined power grid system based on hydrogen energy storage technology. By considering constraints such as system power balance, sustainable energy output power, and energy storage system operation balance, a mathematical model is established and solved with the minimum operating cost as the objective function. Finally, the load and sustainable energy potential data of each California region are used to verify the superiority of the system proposed in this paper.

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Uvarialeptone B has the ability to kill and inhibit the growth of cancer cells. In this study, a retrosynthetic analysis and a synthetic method will be listed and found, using some traditional organic chemical reactions, such as Fleming-Tamao oxidation and DA reaction. It is the aim of this essay to propose a synthetic method to produce uvarialeptone B.

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