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RNA secondary structure prediction using transformer-based deep learning models
- 1 Computer Science, Johns Hopkins University
- 2 Computer Science,Columbia University
- 3 Computer Science,Northeastern University
- 4 Computer Science,Northeastern University
- 5 Software development ,Telecommunication Systems Management ,Northeastern University
* Author to whom correspondence should be addressed.
Abstract
The Human Genome Project has led to an exponential increase in data related to the sequence, structure, and function of biomolecules. Bioinformatics is an interdisciplinary research field that primarily uses computational methods to analyze large amounts of biological macromolecule data. Its goal is to discover hidden biological patterns and related information. Furthermore, analysing additional relevant information can enhance the study of biological operating mechanisms. This paper discusses the fundamental concepts of RNA, RNA secondary structure, and its prediction.Subsequently, the application of machine learning technologies in predicting the structure of biological macromolecules is explored. This chapter describes the relevant knowledge of algorithms and computational complexity and presents a RNA tertiary structure prediction algorithm based on ResNet. To address the issue of the current scoring function's unsuitability for long RNA, a scoring model based on ResNet is proposed, and a structure prediction algorithm is designed. The chapter concludes by presenting some open and interesting challenges in the field of RNA tertiary structure prediction.
Keywords
Gene prediction, RNA secondary structure, Bioengineering, Artificial intelligence, Machine learning
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Cite this article
Zhou,Y.;Zhan,T.;Wu,Y.;Song,B.;Shi,C. (2024). RNA secondary structure prediction using transformer-based deep learning models. Applied and Computational Engineering,64,87-93.
Data availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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Volume title: Proceedings of the 6th International Conference on Computing and Data Science
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