Current development and future prospects of protein hydrogels

Research Article
Open access

Current development and future prospects of protein hydrogels

Bangzhou Kong 1*
  • 1 University of Manchester    
  • *corresponding author bangzhou.kong@postgrad.manchester.au.uk
Published on 7 November 2023 | https://doi.org/10.54254/2755-2721/23/20230623
ACE Vol.23
ISSN (Print): 2755-273X
ISSN (Online): 2755-2721
ISBN (Print): 978-1-83558-067-7
ISBN (Online): 978-1-83558-068-4

Abstract

Protein hydrogels are a class of soft biomaterials that have attracted extensive attention due to their unique properties and potential applications in biomedicine in recent years. This paper explores the promise of protein hydrogels, discussing their advantages, limitations, and future prospects. The biocompatibility, high water content, and tunable mechanical properties of protein hydrogelsmake them appropriate for a variety of uses, including 3D bioprinting, drug delivery, wound healing, and biosensors. However, challenges such as stability and biodegradation, reproducibility and scalability, clinical translation, and a lack of understanding of their mechanisms of action must be addressed to fully realize their potential. The purpose of this paper is to understand the current development status and difficulties of protein hydrogels and to speculate on their future development.

Keywords:

biocompatibility, 3D bioprinting, drug delivery, biodegradation

Kong,B. (2023). Current development and future prospects of protein hydrogels. Applied and Computational Engineering,23,125-129.
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References

[1]. Wichterle, O., Lím, D. (1960). "Hydrophilic Gels for Biological Use". Nature. 185 (4706): 117–118.

[2]. Yang, Y.J., Holmberg, A.L., Olsen, B.D. (2017) Artificially engineered protein polymers. Annu. Rev. Chem. Biomol. Eng., 8, pp. 549-575.

[3]. Jiang, L.B., Su, D.H., Ding, S.L., Zhang, Q.C., Li, Z.F., Chen, et al. (2019) Salt-Assisted Toughening of Protein Hydrogel with Controlled Degradation for Bone Regeneration. Adv. Funct. Mater, 29, p. 1901314.

[4]. Wang, J.J., Wang, Y., Yang, J., Chen, L., et al. (2019) Mechanically Strong and Highly Tough Prolamin Protein Hydrogels Designed from Double-Cross-Linked Assembled Networks. ACS Appl. Polym. Mater., 1 (6), pp. 1272-1279.

[5]. Li, H., Zhao, L., Chen, X.D., Mercade-Prieto, R. (2016) Swelling of whey and egg white protein hydrogels with stranded and particulate microstructures. Int. J. Biol. Macromol., 83, pp. 152-159.

[6]. Bae, K.H., Kurisawa, M. (2016) Emerging hydrogel designs for controlled protein delivery. Biomater. Sci., 4 (8), pp. 1184-1192.

[7]. Gao, X., Fang, J., Xue, B., Fu, L., Li, H. (2016) Engineering Protein Hydrogels Using SpyCatcher-SpyTag Chemistry. Biomacromolecules, 17 (9), pp. 2812-2819.

[8]. de Kruif, C.G., Anema, S.G., Zhu, C.J., Havea, P., Coker, C. (2015) Water holding capacity and swelling of casein hydrogels. Food. Hydrocoll., 44, pp. 372-379.

Cite this article

Kong,B. (2023). Current development and future prospects of protein hydrogels. Applied and Computational Engineering,23,125-129.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 2023 International Conference on Functional Materials and Civil Engineering

ISBN：978-1-83558-067-7(Print) / 978-1-83558-068-4(Online)
Editor：Bhupesh Kumar
Conference website: https://www.conffmce.org/
Conference date: 26 August 2023
Series: Applied and Computational Engineering
Volume number: Vol.23
ISSN：2755-2721(Print) / 2755-273X(Online)

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References

[1]. Wichterle, O., Lím, D. (1960). "Hydrophilic Gels for Biological Use". Nature. 185 (4706): 117–118.

[2]. Yang, Y.J., Holmberg, A.L., Olsen, B.D. (2017) Artificially engineered protein polymers. Annu. Rev. Chem. Biomol. Eng., 8, pp. 549-575.

[3]. Jiang, L.B., Su, D.H., Ding, S.L., Zhang, Q.C., Li, Z.F., Chen, et al. (2019) Salt-Assisted Toughening of Protein Hydrogel with Controlled Degradation for Bone Regeneration. Adv. Funct. Mater, 29, p. 1901314.

[4]. Wang, J.J., Wang, Y., Yang, J., Chen, L., et al. (2019) Mechanically Strong and Highly Tough Prolamin Protein Hydrogels Designed from Double-Cross-Linked Assembled Networks. ACS Appl. Polym. Mater., 1 (6), pp. 1272-1279.

[5]. Li, H., Zhao, L., Chen, X.D., Mercade-Prieto, R. (2016) Swelling of whey and egg white protein hydrogels with stranded and particulate microstructures. Int. J. Biol. Macromol., 83, pp. 152-159.

[6]. Bae, K.H., Kurisawa, M. (2016) Emerging hydrogel designs for controlled protein delivery. Biomater. Sci., 4 (8), pp. 1184-1192.

[7]. Gao, X., Fang, J., Xue, B., Fu, L., Li, H. (2016) Engineering Protein Hydrogels Using SpyCatcher-SpyTag Chemistry. Biomacromolecules, 17 (9), pp. 2812-2819.

[8]. de Kruif, C.G., Anema, S.G., Zhu, C.J., Havea, P., Coker, C. (2015) Water holding capacity and swelling of casein hydrogels. Food. Hydrocoll., 44, pp. 372-379.

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