Poly (Lactic Acid) Applications in Biomedical Engineering

Research Article
Open access

Poly (Lactic Acid) Applications in Biomedical Engineering

Bowen Luo 1*
  • 1 Cornell University    
  • *corresponding author bl747@cornell.edu
Published on 7 November 2023 | https://doi.org/10.54254/2755-2721/24/20230713
ACE Vol.24
ISSN (Print): 2755-273X
ISSN (Online): 2755-2721
ISBN (Print): 978-1-83558-069-1
ISBN (Online): 978-1-83558-070-7

Abstract

Medical devices like implants are playing a pivotal role in medicine. As a polyester, Polylactic acid (PLA) and its copolymers are widely used in the medical area. They are used in several sections including cardiovascular and orthopedic devices, as well as advanced technologies of tissue engineering and drug delivery. In this paper, cardiovascular devices including applications of PLLA coating as drug delivery system and BVS material are introduced. Specifically, PLA can be used to foster scaffolds for bone tissue and cardiovascular tissue engineering. Then this paper introduces PLA applied in the form of nanoparticles and micelles in drug delivery. The special degrading process makes PLA an active drug delivery carrier. And it could also be used to produce biodegradable orthopaedic operation devices and offer the advantage of being free from taking out of the human body. Processing techniques are pivotal prerequisites of applications of medical usage, like electrospun fibers are used in cardiovascular and drug delivery applications. The paper summarizes the use of PLA material in those areas, and foresees the future for a prediction of the attractive prospect. Although the applications are faced with limitations like mechanical properties now, they still have a promising future in biomedicine.

Keywords:

polylactic acid, nanofiber, electrospun fiber, tissue engineering

Luo,B. (2023). Poly (Lactic Acid) Applications in Biomedical Engineering. Applied and Computational Engineering,24,226-230.
Export citation

References

[1]. Silva D, Kaduri M, Poley M, et al. 2018 Chem. Eng. J. 340 9-14

[2]. Hamad K, Kaseem M, Yang HW, et al. 2015 Express Polym. Lett. 9 112002-112002

[3]. Gonçalves C, Gonçalves IC, Magalhães FD, Pinto AM 2017 Polymers (Basel) 9 269

[4]. Sasikumar Y, Srinivasan A, Hrishikesan E 2021 Nanomaterials for Medical Implants. In: Santra, T.S., Mohan, L. (eds) Nanomaterials and Their Biomedical Applications (Singapore: Springer) vol 16

[5]. Uurto I, Mikkonen J, Parkkinen J, Keski-Nisula L, et al. 2005J. Endovasc. Ther. 12 371-379

[6]. Karagkiozaki V, Logothetidis S, Kassavetis S, Giannoglou G 2010 Int. J. Nanomedicine 5 239-248

[7]. Bakola V, Karagkiozaki V, Tsiapla AR, et al. 2018 Nanotechnology 29 275101

[8]. Jia L, Li Y 2021 Composites Science and Engineering 5 61-67

[9]. Xue J, Wu T, Dai Y, Xia Y 2019 Chem. Rev.119 5298-5415

[10]. Hadasha W, Bezuidenhout D 2017 Poly(lactic acid) as Biomaterial for Cardiovascular Devices and Tissue Engineering Applications. In: Di Lorenzo, M., Androsch, R. (eds) Industrial Applications of Poly(lactic acid) (Cham: Springer) vol 282

[11]. Yan C, Ren Y, Sun X, et al. 2020 J. Photochem. Photobio. B Bio 202 111680

[12]. P Pawar R, U Tekale S, U Shisodia S, T Totre J, J Domb A 2014 Recent Patents on Regenerative Medicine 4 40-51

[13]. Grémare A, Guduric V, Bareille R, et al. 2018 J. Biomed. Mater. Res. A 106 887-894

[14]. Zhu M, Gu J, He L, Mahar FK, Kim I, Wei K 2019 Fibers Polym 20 1850–1856

[15]. Kohno M, Andhariya JV, Wan B, Bao Q, Rothstein S, Hezel M, Wang Y, Burgess DJ 2022 Int J Pharmaceut 582 119339

[16]. Li J, Ding J, Liu T, et al. 2017 Poly(lactic acid) Controlled Drug Delivery. In: Di Lorenzo, M., Androsch, R. (eds) Industrial Applications of Poly(lactic acid) (Cham: Springer) vol 282

[17]. Balla E, Daniilidis V, Karlioti G, et al. 2021 Polymers (Basel) 13 1822

[18]. Narayanan G, Vernekar VN, Kuyinu EL, Laurencin CT 2016 Adv. Drug Deliver. Rev. 107 247-276

[19]. Fouly A, Alnaser IA, Assaifan AK, Abdo HS 2022 Polymers 14 3321

Cite this article

Luo,B. (2023). Poly (Lactic Acid) Applications in Biomedical Engineering. Applied and Computational Engineering,24,226-230.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

Disclaimer/Publisher's Note

The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of EWA Publishing and/or the editor(s). EWA Publishing and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

About volume

Volume title: Proceedings of the 2023 International Conference on Functional Materials and Civil Engineering

ISBN：978-1-83558-069-1(Print) / 978-1-83558-070-7(Online)
Editor：Bhupesh Kumar
Conference website: https://www.conffmce.org/
Conference date: 26 August 2023
Series: Applied and Computational Engineering
Volume number: Vol.24
ISSN：2755-2721(Print) / 2755-273X(Online)

© 2024 by the author(s). Licensee EWA Publishing, Oxford, UK. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. Authors who publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open access policy for details).

References

[1]. Silva D, Kaduri M, Poley M, et al. 2018 Chem. Eng. J. 340 9-14

[2]. Hamad K, Kaseem M, Yang HW, et al. 2015 Express Polym. Lett. 9 112002-112002

[3]. Gonçalves C, Gonçalves IC, Magalhães FD, Pinto AM 2017 Polymers (Basel) 9 269

[4]. Sasikumar Y, Srinivasan A, Hrishikesan E 2021 Nanomaterials for Medical Implants. In: Santra, T.S., Mohan, L. (eds) Nanomaterials and Their Biomedical Applications (Singapore: Springer) vol 16

[5]. Uurto I, Mikkonen J, Parkkinen J, Keski-Nisula L, et al. 2005J. Endovasc. Ther. 12 371-379

[6]. Karagkiozaki V, Logothetidis S, Kassavetis S, Giannoglou G 2010 Int. J. Nanomedicine 5 239-248

[7]. Bakola V, Karagkiozaki V, Tsiapla AR, et al. 2018 Nanotechnology 29 275101

[8]. Jia L, Li Y 2021 Composites Science and Engineering 5 61-67

[9]. Xue J, Wu T, Dai Y, Xia Y 2019 Chem. Rev.119 5298-5415

[10]. Hadasha W, Bezuidenhout D 2017 Poly(lactic acid) as Biomaterial for Cardiovascular Devices and Tissue Engineering Applications. In: Di Lorenzo, M., Androsch, R. (eds) Industrial Applications of Poly(lactic acid) (Cham: Springer) vol 282

[11]. Yan C, Ren Y, Sun X, et al. 2020 J. Photochem. Photobio. B Bio 202 111680

[12]. P Pawar R, U Tekale S, U Shisodia S, T Totre J, J Domb A 2014 Recent Patents on Regenerative Medicine 4 40-51

[13]. Grémare A, Guduric V, Bareille R, et al. 2018 J. Biomed. Mater. Res. A 106 887-894

[14]. Zhu M, Gu J, He L, Mahar FK, Kim I, Wei K 2019 Fibers Polym 20 1850–1856

[15]. Kohno M, Andhariya JV, Wan B, Bao Q, Rothstein S, Hezel M, Wang Y, Burgess DJ 2022 Int J Pharmaceut 582 119339

[16]. Li J, Ding J, Liu T, et al. 2017 Poly(lactic acid) Controlled Drug Delivery. In: Di Lorenzo, M., Androsch, R. (eds) Industrial Applications of Poly(lactic acid) (Cham: Springer) vol 282

[17]. Balla E, Daniilidis V, Karlioti G, et al. 2021 Polymers (Basel) 13 1822

[18]. Narayanan G, Vernekar VN, Kuyinu EL, Laurencin CT 2016 Adv. Drug Deliver. Rev. 107 247-276

[19]. Fouly A, Alnaser IA, Assaifan AK, Abdo HS 2022 Polymers 14 3321

For authors
Guide for authors Policies for authors Aims and scope Subscription Open access policy
For editors
Policies for editors Editorial board
For reviewers
Policies for reviewers Privacy policy

Cookies are used by this site.
Copyright © 2024 EWA Publishing, its licensors, and contributors. All rights reserved, including text and data mining, AI training, and similar technologies.