Childhood Trauma and Adolescent Anxiety Disorders: A Comprehensive Study from Root Causes to Intervention

Research Article
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Childhood Trauma and Adolescent Anxiety Disorders: A Comprehensive Study from Root Causes to Intervention

Ruonan Kong 1*
  • 1 McGill University    
  • *corresponding author ruonan.kong@mail.mcgill.ca
Published on 14 March 2024 | https://doi.org/10.54254/2753-7048/43/20240655
LNEP Vol.43
ISSN (Print): 2753-7048
ISSN (Online): 2753-7056
ISBN (Print): 978-1-83558-341-8
ISBN (Online): 978-1-83558-342-5

Abstract

Anxiety disorders represent a widespread psychological challenge, with a notably increased risk among adolescents and early adults who have experienced childhood trauma. This study synthesizes existing knowledge on the origins, classification, and emergence of anxiety disorders, underscoring the significant role of childhood trauma. The etiology of anxiety disorders is multifactorial, entwining genetic predispositions with environmental stressors. Familial patterns and neurochemical dysregulations, particularly concerning serotonin and dopamine, are implicated in their pathogenesis. Empirical evidence points to both genetic and neurobiological factors, including emotional processing abnormalities and neurophysiological deviations, as influential in the manifestation of anxiety disorders. Additionally, environmental aspects like childhood trauma and sustained stress are confirmed as pivotal in exacerbating these disorders. Extensive examinations demonstrate a persistent and affirmative association between the emergence of anxiety-related illnesses and childhood trauma. These traumatic experiences contribute to psychiatric vulnerabilities, notably in anxiety and depressive disorders. Moreover, maladaptive coping mechanisms resulting from early trauma, such as substance misuse, may indirectly escalate anxiety and depressive symptoms, compounding the individual's struggle with stress and anxiety. The evidence establishes a stark connection between childhood trauma and anxiety disorders, advocating for targeted prevention and intervention strategies. The study also calls for nuanced future research, particularly across diverse cultural backgrounds, to enhance the understanding and treatment of anxiety disorders. These insights carry significant weight for educational, therapeutic, and familial interventions, promoting a proactive stance on childhood trauma's psychological aftermath.

Keywords:

Childhood Trauma, Anxiety Disorders, Genetic and Environmental Influences, Intervention Strategies

Kong,R. (2024). Childhood Trauma and Adolescent Anxiety Disorders: A Comprehensive Study from Root Causes to Intervention . Lecture Notes in Education Psychology and Public Media,43,67-74.
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1. Introduction

One of the main causes of impairment and lower standards of life is anxiety, a psychological condition that is common across the world. Anxiety disorders have onset at all ages, it may not matter if it is adolescent adulthood or older adults. However, with the onset of trauma/childhood abuse, the risk of developing an anxiety disorder increases greatly in adolescence and early adulthood. Many children are experiencing or have experienced bad childhood trauma, such as family of origin or unexpected events. The underlying causes of these disorders continue to be the subject of extensive research. Historically, research has often highlighted the fact that children experiencing childhood trauma early in life may significantly contribute to the emergence of anxiety disorders in adolescence. The importance of understanding this link cannot be underestimated. If a positive relationship between early trauma and adolescent anxiety can be clearly established, this will pave the way for increased preventative measures and therapeutic interventions, as well as a greater focus on the importance of development during childhood. The purpose of this study is to delve into the literature related to this, from past grounded theory to the most recent empirical research, in order to understand the nature and complexity of this potential relationship.

The practical implications of this research choice are extensive. Adolescents struggling with anxiety disorders often face many challenges such as learning difficulties, inability to concentrate, social isolation, and even in more severe cases adolescents may develop self-harming behaviors or a variety of somatization symptoms due to anxiety. Considering early childhood trauma as an important predictor will allow early educators, children's caregivers, and psychotherapeutic professionals to intervene earlier and more effectively with related prevention or treatment, to understand the problem at its source, and to address the underlying conflict. The hippocampus, amygdala, and prefrontal cortex all undergo structural and functional alterations that contribute significantly to the effects of childhood trauma on mental health. Early preventative treatments are crucial in avoiding mental illnesses linked to adverse childhood experiences [1]. This paper will review how childhood trauma can have an impact on one's ability to develop mental disorders (especially mood) and understand disorders and anxiety disorders by analyzing papers on similar topics.

2. Description of Research Subjects

2.1. Introduction to the Concept

Anxiety disorders are a collection of disorders marked by excessive fear, anxiety, and related behavioral abnormalities. Normally, anxiety is an emotional state, a normal response to stress that everyone needs to have. These conditions can take many various forms, ranging from generalized anxiety disorder to more specialized ones like agoraphobia, panic disorder, or social anxiety disorder. About 40 million Americans suffer from anxiety disorders, making them the most prevalent mental health issue in the country. The majority of anxiety disorders start in childhood, adolescence, or early adulthood. When discussing adolescent onset anxiety disorders, it is important to consider the potential role of childhood trauma. Childhood trauma, which may include experiences of abuse, neglect, or witnessing violence, can profoundly affect a child's developing brain and increase the risk of developing an anxiety disorder later in life. The onset of anxiety disorders in adolescents is of particular concern because this developmental period is a critical time for forming social relationships, achieving academic success, and establishing self-identity. Additionally, there can be a higher chance of acquiring other mental health issues including depression. There is a negative correlation between the lifetime prevalence of anxiety disorders in children and adolescents (15-20%) with their academic success, home life, and leisure activities [2].

2.2. Classification and Characterization

Historically, anxiety disorders were categorized based on their triggers and manifestations. Today, the famous psychologist Sigmund Freud coined many of the terms used for various anxiety disorders in the DSM-I and DSM-II. With the advancement of medical treatment and mankind's greater understanding of mental disorders, in the most recent DSM-5, anxiety disorders are classified into three categories based on common characteristics of anxiety disorders: anxiety disorders, obsessive-compulsive disorders, and trauma and stress-related disorders [3]. Currently, there are four main types of mainstream anxiety disorders that society is exposed to, namely generalized anxiety disorder, panic disorder, social anxiety disorder and phobia-related disorders [4].

2.3. Influencing Factors/dependent variables

Anxiety disorders are intricate, multidimensional conditions that are impacted by a wide range of elements, including environmental stressors and genetic susceptibility. Several research works have demonstrated the significant influence of heredity on the emergence of anxiety disorders. For instance, the majority of mental diseases have a significant hereditary component, and individuals with a family history of anxiety or similar psychiatric disorders are more likely to acquire anxiety disorders. Clinical genetics studies have shown that genetics have a strong influence on the pathogenesis of anxiety disorders, with heritability rates ranging from approximately 30-67%, and there is already evidence to suggest that the vulnerability genes in people with anxiety disorders may drive anxiety-related affective processing, as well as neurophysiological measures (e.g., startle reflexes or activity of the peripheral sympathetic nervous system) of neural activity [5].

Brain chemistry is a key factor. Imbalances in neurotransmitters such as serotonin and dopamine have been linked to an increase in anxiety disorders, as they play a key role in emotion regulation and stress response. Low or imbalanced serotonin levels are associated with anxiety and depression. These levels can be influenced by genes and mood states, and their imbalance can lead to increased anxiety. In addition, studies have shown that therapeutic interventions can increase natural serotonin levels, further emphasizing its importance in controlling anxiety. Dopamine is also a key neurotransmitter; people suffering from social anxiety may have dopamine receptor problems, and increasing dopamine levels can reduce the onset of anxiety disorders [6]. And the direct relationship between serotonin and dopamine can also affect anxiety attacks. Recent research from Uppsala University explored the balance between serotonin and dopamine in relation to social anxiety disorder. Researchers discovered that patients with social anxiety disorder have a markedly altered equilibrium between their serotonin and dopamine transmission networks compared to controls. Rather than concentrating on each neurotransmitter separately, the interactions between these transmitters may play a more significant role in understanding the variations between individuals with social anxiety disorder and controls. In future research into the effects of neurotransmitters on mental health, it is important to not only focus on single signaling substances, but also to consider the balance and interactions between different systems [7].

In addition to the innate genetics perspective, another important aspect is environmental factors. Traumatic events, chronic stress and even everyday stress can be catalysts for anxiety disorders. A study of Chinese university students using a longitudinal survey and experience sampling methods found that daily perceived stress and negative emotions (such as depression and anxiety) reinforced each other [8].

Scientific studies have confirmed that early adverse experiences are closely linked to the development of anxiety disorders later in life. Childhood trauma such as abuse, neglect or witnessing violence can disrupt normal psychological development and stress response mechanisms. Such disruptions often lead to heightened anxiety responses, increasing the likelihood of developing an anxiety disorder in adolescence or adulthood. Research, including the Dutch Study of Depression and Anxiety (NESDA) and a 6-year longitudinal study in the Netherlands, suggests that people who experience childhood trauma (especially severe trauma) are at higher risk of developing anxiety disorders and that symptoms persist and evolve over time. Childhood trauma is also associated with maladaptive personality traits, dysregulated stress systems, declining health, and brain changes. This leads to a collective impact on the brain, mind and body from the environment and different events experienced in early childhood, and a greater susceptibility to emotional disorders [1]. These findings emphasise the significant impact of childhood trauma on mental health, influencing the onset and development of various anxiety disorders [9]. There is strong evidence of a strong link between traumatic experiences in childhood and the development of future mental illness. This link is particularly evident in cases of bullying, emotional abuse, physical abuse, or the loss of a biological parent. Research data suggests that childhood and adolescence are critical periods of increased risk for developing mental illness later in life and an important window of time for intervention strategies that require special attention [10].

3. Relationship between Childhood Trauma and Anxiety Disorders

3.1. Direct Evidence from Empirical Research

The development of anxiety disorders has been linked to childhood trauma, which has drawn significant attention from developmental and clinical psychologists. Numerous empirical studies have explored this relationship in detail, offering valuable content and insights into the relationship between variations in childhood environment and the likelihood of anxiety symptomatology. This section provides a rigorous and comprehensive review of the relevant research that continues to provide compelling summaries of, and evidence for, a direct and positive relationship between childhood trauma and anxiety disorders.

There is a lack of consistency in the definition of childhood adversity, which for the purposes of this article is defined as the fact that during childhood or adolescence, individuals may encounter environmental conditions that require significant psychological, social, or neurobiological adaptation for the average child and that represent a significant deviation from the expected environment [11]. And evidence from a variety of methods, including surveys, behavioral observations and self-reports to name a few, consistently suggests that there is a positive relationship between traumatic events and adversity experienced in childhood and anxiety disorders directly.

Extensive research has explored the links between childhood trauma and mental health, revealing substantial links to anxiety disorders. The main source of information for this analysis is a six-year longitudinal study and the Dutch Study of Depression and Anxiety (NESDA). One prior study highlights the positive association between childhood trauma (CT) and the development of psychiatric disorders in adulthood. This correlation is especially noticeable in the case of anxiety and depressive disorders, which may be a separate sub-type of psychopathology with an earlier start, more persistent symptoms, a higher likelihood of comorbidity, and less successful treatment results [9]. The choice of studies analyzed was based on their direct examination of the impact of childhood trauma on the development of subsequent anxiety disorders, with a preference for longitudinal studies to track changes over time.

Furthermore, a number of empirical research conducted at the biological level have examined the influence of childhood trauma on the path of anxiety disorder development. Children who experience adverse events early in life experience a subsequent increase in stress, and these stresses cause parts of the central nervous system (CNS) to remain sensitive for longer periods of time, particularly the corticotropin-releasing factor (CRF) system and other neurotransmitter systems. Since these circuits are directly related to regulating stress and mood changes, the development of this vulnerability invariably increases the likelihood of anxiety [12].

Examining one's history can also provide relevant evidence for persons with documented anxiety disorders. In a survey-style study, patients diagnosed with anxiety or adjustment disorder were asked to answer a series of cross-sectional questionnaires about various aspects of their lives, such as whether or not they had experienced emotional or physical abuse as children, anxiety, and conditions related to physical chronic pain. A clinical sample of patients with anxiety or adjustment disorders who reported pain (pertaining to a history of childhood trauma) was compared with a community sample of people who expressed anxiety and chronic pain problems. The majority of these self-reports revealed information in the study's final conclusions about different kinds of childhood trauma that may have contributed to disorders connected to anxiety and pain in adulthood. In community populations, reporting anxiety is linked to a higher occurrence of emotional abuse and neglect of children by the family of origin [13].

3.2. Specific Analyses of the above Empirical Studies

The above studies for investigating and validating The association between childhood trauma and psychological disorders such as anxiety disorders have certainly revealed many important insights and provided much favorable support. But there are also several possible limitations involved that need to be considered. Firstly, self-reported questionnaire measures introduce a lot of bias in the subjective awareness of the population being tested, and enquiries about childhood in particular may provoke participants to overestimate the impact of the childhood trauma they have experienced on them. Therefore, in this type of study, some objective measures based on introspective questionnaires should be considered in the future to include some factors that cannot be subjectively influenced. For example, physiological responses, heart rate, skin conductivity, and other neurological indicators. This will further improve the reliability of this type of research.

Secondly, although many people nowadays promote longitudinal studies over a long period of time, the main idea is that the researcher can observe more accurately the relationship between variables, how they change over time, and how certain events or conditions affect the subsequent development of an individual. However, it is also important to note that longitudinal studies are not perfect, and in addition to being costly and time-consuming, researchers also need to be aware that temporal associations do not necessarily imply causation. It remains challenging to establish a direct causal relationship between childhood trauma and anxiety disorders. And methodological consistency is also a part that cannot be ignored as the study progresses over time; measurement tools and techniques may be time-sensitive and need to be updated or changed as knowledge is updated.

The last limitation that needs to be mentioned is that most of the content related to childhood trauma and anxiety disorders may not adequately take into account the differences in cultural and social contexts related to the study. For example, many of the studies involved populations of children or people with anxiety disorders from the West who experienced more individualistic societies. The lack of parenting styles influenced by cultural factors of traditional collectivist societies may have varying degrees of mental health impact on children, for example differences in parenting styles may be associated with trauma and anxiety [14]. Cultural norms, societal values, and environmental factors play a critical role in shaping an individual's traumatic experiences and their subsequent mental health outcomes. This is something that researchers need to be aware of in subsequent studies in this area.

Despite these limitations, the empirical studies reviewed above do contribute to the understanding of the relationship between childhood trauma and the emergence of anxiety disorders as well as other adverse reactions. These studies provide evidence for further awareness of the importance of maintaining a developmental environment for children and understanding their emotions. Future research could address the above limitations and more comprehensively measure their causal relationship from a multidimensional perspective. Thus, making the dynamic scholarship of childhood trauma and anxiety disorders in children more accessible.

4. Indirect Relation between Early Trauma and Mental Health

Early trauma often sets the stage for the development of maladaptive coping mechanisms, which may indirectly lead to anxiety disorders. As a result of experiencing a very bad situation in childhood, when faced with a similar situation or other difficult to deal with difficulty again in subsequent life, people who have experienced such trauma may be less likely than the general population to deal with it correctly. According to a Khoury research, those who have experienced childhood trauma are more prone to acquire anxiety disorders or other maladaptive coping mechanisms. According to Khoury's research, individuals who have experienced childhood trauma are more prone to turn to unhealthy coping mechanisms like drug misuse, which is linked to increased anxiety and depressive symptoms. While these behaviors they adopt can briefly session their pain, they will not help them address the underlying issues. Most notably, it may further add to their anxiety symptoms and lead to an anxiety attack [15]. For example, drug and substance abuse may initially numb the pain and provide a brief relief from stress, but ultimately exacerbate anxiety levels due to the adverse physical and psychological consequences they cause.

5. Discussion and Suggestion

The majority of the research points to a direct connection between early childhood trauma and the emergence of anxiety problems in teenagers. This review-style essay offers a thorough analysis of the connection—both direct and indirect—between anxiety disorders and childhood trauma. Childhood trauma, such as abuse, neglect, or witnessing violence, is recognized as a significant predictor of anxiety disorders, with far-reaching consequences for mental health. The article describes the categorical features of anxiety disorders and the factors that influence their onset, including genetic factors and changes in brain chemistry, for example, imbalances in serotonin and dopamine are associated with increased anxiety. In particular, it elaborates that childhood environmental factors-traumatic events and chronic stress are also important catalysts in the development of anxiety disorders.

By analyzing empirical evidence from a number of different research methods, the article provides comprehensive and convincing evidence for a positive relationship between childhood trauma and anxiety disorders. It also presents some limitations to this empirical evidence, such as the subjectivity of self-report questionnaires and differences in cultural backgrounds. Future studies must consider these constraints and be carried out in a more diverse cultural setting. Subsequent investigations must consider these constraints and be carried out within a more extensive cultural setting. Apart from trials that confirm the direct impacts of factors, research has indicated that trauma experienced as a kid results in the formation of maladaptive coping strategies and alters the perception of pain, both of which are indirect causes of anxiety disorders. In terms of future research directions, cross-cultural studies have been analyzed as crucial for a deeper understanding of how anxiety disorders manifest in different social and cultural contexts, whether in childhood, adolescence, or adulthood. A better understanding of the mental health problems that may result from cultural differences can be achieved. In turn, sensitivity to anxiety disorders in different cultural contexts can be improved. Finally, it is crucial to evaluate and refine prevention and treatment strategies for anxiety disorders, especially intervention methods for childhood trauma. These studies can provide a stronger scientific basis for the effective treatment of anxiety disorders.

6. Conclusion

Childhood adversity as a key factor influencing the onset of anxiety disorders and other major psychiatric disorders needs to be thoroughly investigated for their interrelationships. Too many people across the globe suffer from anxiety disorders and hence the main aim of this study was to explore the correlation between childhood trauma in terms of its underlying environmental factor and anxiety disorders. By further analyzing the research and elucidating these direct and indirect links, this study endeavors to provide a stronger scientific basis for the effective treatment of anxiety disorders.

The present study adds to and summarizes the substantial body of research that has demonstrated the crucial role that childhood trauma plays in the development of anxiety disorders. It does this by examining the intricate, multifaceted link between childhood trauma and anxiety disorders from an integrative perspective. This study has broad practical implications for education, psychology, and family dynamics, among other domains. It is important to raise awareness of the importance of the environment in which children grow up, to increase the ability to recognize and deal with childhood trauma, and to provide the necessary support and resources. As the understanding grows, it becomes clear that addressing trauma and its effects early can pave the way for healthier lives for adolescents and adults. Early traumas can no longer be overlooked or ignored; they play an important role in the mental health trajectory of many people. As the understanding of this area grows, it is hoped that interventions will become more effective, comprehensive, and informed. There may also be a need for more enquiry into the childhoods of those currently suffering from anxiety disorders, as well as research.


References

[1]. Kuzminskaite, E., Penninx, B. W. J. H., van Harmelen, A.-L., Elzinga, B. M., Hovens, J. G. F. M., & Vinkers, C. H. (2021). Childhood Trauma in Adult Depressive and Anxiety Disorders: An Integrated Review on Psychological and Biological Mechanisms in the NESDA Cohort. Journal of Affective Disorders, 283, 179–191. https://doi.org/10.1016/j.jad.2021.01.054

[2]. Zhou, X., Zhang, Y., Furukawa, T. A., Cuijpers, P., Pu, J., Weisz, J. R., Yang, L., Hetrick, S. E., Del Giovane, C., Cohen, D., James, A. C., Yuan, S., Whittington, C., Jiang, X., Teng, T., Cipriani, A., & Xie, P. (2019). Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis. JAMA Psychiatry, 76(1), 41–50. https://doi.org/10.1001/jamapsychiatry.2018.3070

[3]. Crocq, M.-A. (2015). A history of anxiety: From Hippocrates to DSM. Dialogues in Clinical Neuroscience, 17(3), 319–325.

[4]. Anxiety Disorders—National Institute of Mental Health (NIMH). (n.d.). Retrieved December 2, 2023, from https://www.nimh.nih.gov/health/topics/anxiety-disorders

[5]. Katharina Domschke, & Deckert, J. (2012). Genetics of anxiety disorders—Status quo and quo vadis. Current Pharmaceutical Design, 18(35), 5691–5698. https://doi.org/10.2174/138161212803530781

[6]. The Biochemistry of Anxiety. (n.d.). Retrieved November 25, 2023, from https://www.calmclinic.com/anxiety/biochemistry-of-anxiety

[7]. Hjorth, O. R., Frick, A., Gingnell, M., Hoppe, J. M., Faria, V., Hultberg, S., Alaie, I., Månsson, K. N. T., Wahlstedt, K., Jonasson, M., Lubberink, M., Antoni, G., Fredrikson, M., & Furmark, T. (2021). Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: A multitracer positron emission tomography study. Molecular Psychiatry, 26(8), Article 8. https://doi.org/10.1038/s41380-019-0618-7

[8]. Frontiers | Tracking perceived stress, anxiety, and depression in daily life: A double-downward spiral process. (n.d.). Retrieved November 25, 2023, from https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1114332/full

[9]. Kuzminskaite, E., Vinkers, C. H., Milaneschi, Y., Giltay, E. J., & Penninx, B. W. J. H. (2022). Childhood trauma and its impact on depressive and anxiety symptomatology in adulthood: A 6-year longitudinal study. Journal of Affective Disorders, 312, 322–330. https://doi.org/10.1016/j.jad.2022.06.057

[10]. McKay, M. T., Cannon, M., Chambers, D., Conroy, R. M., Coughlan, H., Dodd, P., Healy, C., O’Donnell, L., & Clarke, M. C. (2021). Childhood trauma and adult mental disorder: A systematic review and meta-analysis of longitudinal cohort studies. Acta Psychiatrica Scandinavica, 143(3), 189–205. https://doi.org/10.1111/acps.13268

[11]. McLaughlin, K. A. (2016). Future Directions in Childhood Adversity and Youth Psychopathology. Journal of Clinical Child and Adolescent Psychology : The Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 45(3), 361–382. https://doi.org/10.1080/15374416.2015.1110823

[12]. Heim, C., & Nemeroff, C. B. (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biological Psychiatry, 49(12), 1023–1039. https://doi.org/10.1016/S0006-3223(01)01157-X

[13]. Kascakova, N., Furstova, J., Hasto, J., Madarasova Geckova, A., & Tavel, P. (2020). The Unholy Trinity: Childhood Trauma, Adulthood Anxiety, and Long-Term Pain. International Journal of Environmental Research and Public Health, 17(2), Article 2. https://doi.org/10.3390/ijerph17020414

[14]. Basu, D., & Ghosh, A. (2014). Developmental trajectory of substance use disorders: What role do the parents play (or are perceived to play)? The Indian Journal of Medical Research, 139(6), 796–798.

[15]. Khoury, L., Tang, Y. L., Bradley, B., Cubells, J. F., & Ressler, K. J. (2010). Substance use, childhood traumatic experience, and Posttraumatic Stress Disorder in an urban civilian population. Depression and Anxiety, 27(12), 1077–1086. https://doi.org/10.1002/da.20751


Cite this article

Kong,R. (2024). Childhood Trauma and Adolescent Anxiety Disorders: A Comprehensive Study from Root Causes to Intervention . Lecture Notes in Education Psychology and Public Media,43,67-74.

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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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ISBN:978-1-83558-341-8(Print) / 978-1-83558-342-5(Online)
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ISSN:2753-7048(Print) / 2753-7056(Online)

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References

[1]. Kuzminskaite, E., Penninx, B. W. J. H., van Harmelen, A.-L., Elzinga, B. M., Hovens, J. G. F. M., & Vinkers, C. H. (2021). Childhood Trauma in Adult Depressive and Anxiety Disorders: An Integrated Review on Psychological and Biological Mechanisms in the NESDA Cohort. Journal of Affective Disorders, 283, 179–191. https://doi.org/10.1016/j.jad.2021.01.054

[2]. Zhou, X., Zhang, Y., Furukawa, T. A., Cuijpers, P., Pu, J., Weisz, J. R., Yang, L., Hetrick, S. E., Del Giovane, C., Cohen, D., James, A. C., Yuan, S., Whittington, C., Jiang, X., Teng, T., Cipriani, A., & Xie, P. (2019). Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis. JAMA Psychiatry, 76(1), 41–50. https://doi.org/10.1001/jamapsychiatry.2018.3070

[3]. Crocq, M.-A. (2015). A history of anxiety: From Hippocrates to DSM. Dialogues in Clinical Neuroscience, 17(3), 319–325.

[4]. Anxiety Disorders—National Institute of Mental Health (NIMH). (n.d.). Retrieved December 2, 2023, from https://www.nimh.nih.gov/health/topics/anxiety-disorders

[5]. Katharina Domschke, & Deckert, J. (2012). Genetics of anxiety disorders—Status quo and quo vadis. Current Pharmaceutical Design, 18(35), 5691–5698. https://doi.org/10.2174/138161212803530781

[6]. The Biochemistry of Anxiety. (n.d.). Retrieved November 25, 2023, from https://www.calmclinic.com/anxiety/biochemistry-of-anxiety

[7]. Hjorth, O. R., Frick, A., Gingnell, M., Hoppe, J. M., Faria, V., Hultberg, S., Alaie, I., Månsson, K. N. T., Wahlstedt, K., Jonasson, M., Lubberink, M., Antoni, G., Fredrikson, M., & Furmark, T. (2021). Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: A multitracer positron emission tomography study. Molecular Psychiatry, 26(8), Article 8. https://doi.org/10.1038/s41380-019-0618-7

[8]. Frontiers | Tracking perceived stress, anxiety, and depression in daily life: A double-downward spiral process. (n.d.). Retrieved November 25, 2023, from https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1114332/full

[9]. Kuzminskaite, E., Vinkers, C. H., Milaneschi, Y., Giltay, E. J., & Penninx, B. W. J. H. (2022). Childhood trauma and its impact on depressive and anxiety symptomatology in adulthood: A 6-year longitudinal study. Journal of Affective Disorders, 312, 322–330. https://doi.org/10.1016/j.jad.2022.06.057

[10]. McKay, M. T., Cannon, M., Chambers, D., Conroy, R. M., Coughlan, H., Dodd, P., Healy, C., O’Donnell, L., & Clarke, M. C. (2021). Childhood trauma and adult mental disorder: A systematic review and meta-analysis of longitudinal cohort studies. Acta Psychiatrica Scandinavica, 143(3), 189–205. https://doi.org/10.1111/acps.13268

[11]. McLaughlin, K. A. (2016). Future Directions in Childhood Adversity and Youth Psychopathology. Journal of Clinical Child and Adolescent Psychology : The Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 45(3), 361–382. https://doi.org/10.1080/15374416.2015.1110823

[12]. Heim, C., & Nemeroff, C. B. (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biological Psychiatry, 49(12), 1023–1039. https://doi.org/10.1016/S0006-3223(01)01157-X

[13]. Kascakova, N., Furstova, J., Hasto, J., Madarasova Geckova, A., & Tavel, P. (2020). The Unholy Trinity: Childhood Trauma, Adulthood Anxiety, and Long-Term Pain. International Journal of Environmental Research and Public Health, 17(2), Article 2. https://doi.org/10.3390/ijerph17020414

[14]. Basu, D., & Ghosh, A. (2014). Developmental trajectory of substance use disorders: What role do the parents play (or are perceived to play)? The Indian Journal of Medical Research, 139(6), 796–798.

[15]. Khoury, L., Tang, Y. L., Bradley, B., Cubells, J. F., & Ressler, K. J. (2010). Substance use, childhood traumatic experience, and Posttraumatic Stress Disorder in an urban civilian population. Depression and Anxiety, 27(12), 1077–1086. https://doi.org/10.1002/da.20751