Abnormality of Reward Sensitivity in Major Depressive Disorder and Bipolar Disorder

Research Article
Open access

Abnormality of Reward Sensitivity in Major Depressive Disorder and Bipolar Disorder

Yufei Li 1*
  • 1 Department of Psychology, University of Illinois at Urbana Champaign, Champaign, IL    
  • *corresponding author yufeili4@illinois.edu
LNEP Vol.6
ISSN (Print): 2753-7056
ISSN (Online): 2753-7048
ISBN (Print): 978-1-915371-37-9
ISBN (Online): 978-1-915371-38-6

Abstract

Bipolar disorder (BD) and major depressive disorder (MDD) are two major psychiatric disorders that both involve a reward system abnormality. This paper reviews studies on the hyper/hyposensitivity model, also known as the Behavior Approach System (BAS), that emphasize the role of abnormal reward processing in patients with BD and MDD. The paper concludes that BD patients' extremely high reward sensitivity causes manic-related symptoms as well as bipolar depressive symptoms. On the contrary, MDD patients' extremely low reward sensitivity leads to unipolar depressive symptoms such as anhedonia and loss of motivation. Furthermore, this paper discusses the hyper/hyposensitivity model's utility in three areas: how it can aid in disease differentiation and prediction, and how it can be used to develop potential treatments. Because reward sensitivity can be measured using reward tasks, predicting the onset of BD and MDD, making the correct diagnosis, and developing treatments will be easier if the relationship between sensitivity and diseases is clear.

Keywords:

reward, major depressive disorder, bipolar disorder

Li,Y. (2023). Abnormality of Reward Sensitivity in Major Depressive Disorder and Bipolar Disorder. Lecture Notes in Education Psychology and Public Media,6,165-169.
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References

[1]. Whitton, A. E., Treadway, M. T. & Pizzagalli, D. A. Reward processing dysfunction in major depression, bipolar disorder and schizophrenia. Curr Opin Psychiatr 28, 7–12 (2015).

[2]. Duek, O., Osher, Y., Belmaker, R. H., Bersudsky, Y. & Kofman, O. Reward sensitivity and anger in euthymic bipolar disorder. Psychiat Res 215, 95–100 (2014).

[3]. Alloy, L. B., Nusslock, R. & Boland, E. M. The Development and Course of Bipolar Spectrum Disorders: An Integrated Reward and Circadian Rhythm Dysregulation Model. Annu Rev Clin Psycho 11, 1–38 (2015).

[4]. Nusslock, R. & Alloy, L. B. Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective. J Affect Disorders 216, 3–16 (2017).

[5]. Nusslock, R., Young, C. B. & Damme, K. S. F. Elevated reward-related neural activation as a unique biological marker of bipolar disorder: Assessment and treatment implications. Behav Res Ther 62, 74–87 (2014).

[6]. Alloy, L. B., Olino, T., Freed, R. D. & Nusslock, R. Role of Reward Sensitivity and Processing in Major Depressive and Bipolar Spectrum Disorders. Behav Ther 47, 600–621 (2016).

[7]. Bertocci, M. A. et al. The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder. Mol Psychiatr 26, 4137–4145 (2021).

[8]. Smucny, J. et al. Schizophrenia and bipolar disorder are associated with opposite brain reward anticipation-associated response. Neuropsychopharmacol 46, 1152–1160 (2021).

[9]. Berghorst, L. H. et al. Stress and reward processing in bipolar disorder: a functional magnetic resonance imaging study. Bipolar Disord 18, 602–611 (2016).

[10]. Ibanez, A. et al. The Neural Basis of Decision-Making and Reward Processing in Adults with Euthymic Bipolar Disorder or Attention-Deficit/Hyperactivity Disorder (ADHD). Plos One 7, e37306 (2012).

[11]. Cléry-Melin, M.-L., Jollant, F. & Gorwood, P. Reward systems and cognitions in Major Depressive Disorder. Cns Spectrums 24, 64–77 (2019).

[12]. Luking, K. R., Pagliaccio, D., Luby, J. L. & Barch, D. M. Reward Processing and Risk for Depression Across Development. Trends Cogn Sci 20, 456–468 (2016).

[13]. Rupprechter, S., Stankevicius, A., Huys, Q. J. M., Series, P. & Steele, J. D. Abnormal reward valuation and event-related connectivity in unmedicated major depressive disorder. Psychol Med 51, 795–803 (2021).

[14]. Redlich, R. et al. Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study. Neuropsychopharmacol 40, 2623–2631 (2015).

[15]. Satterthwaite, T. D. et al. Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression. Neuropsychopharmacol 40, 2258–2268 (2015).

[16]. Hanford, L. C. et al. The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder. Plos One 14, e0226135 (2019).

[17]. Bart, C. P., Titone, M. K., Ng, T. H., Nusslock, R. & Alloy, L. B. Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration. Clin Psychol Rev 87, 102035 (2021).


Cite this article

Li,Y. (2023). Abnormality of Reward Sensitivity in Major Depressive Disorder and Bipolar Disorder. Lecture Notes in Education Psychology and Public Media,6,165-169.

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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the International Conference on Interdisciplinary Humanities and Communication Studies (ICIHCS 2022), Part 5

ISBN:978-1-915371-37-9(Print) / 978-1-915371-38-6(Online)
Editor:Muhammad Idrees, Matilde Lafuente-Lechuga
Conference website: https://www.icihcs.org/
Conference date: 18 December 2022
Series: Lecture Notes in Education Psychology and Public Media
Volume number: Vol.6
ISSN:2753-7048(Print) / 2753-7056(Online)

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References

[1]. Whitton, A. E., Treadway, M. T. & Pizzagalli, D. A. Reward processing dysfunction in major depression, bipolar disorder and schizophrenia. Curr Opin Psychiatr 28, 7–12 (2015).

[2]. Duek, O., Osher, Y., Belmaker, R. H., Bersudsky, Y. & Kofman, O. Reward sensitivity and anger in euthymic bipolar disorder. Psychiat Res 215, 95–100 (2014).

[3]. Alloy, L. B., Nusslock, R. & Boland, E. M. The Development and Course of Bipolar Spectrum Disorders: An Integrated Reward and Circadian Rhythm Dysregulation Model. Annu Rev Clin Psycho 11, 1–38 (2015).

[4]. Nusslock, R. & Alloy, L. B. Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective. J Affect Disorders 216, 3–16 (2017).

[5]. Nusslock, R., Young, C. B. & Damme, K. S. F. Elevated reward-related neural activation as a unique biological marker of bipolar disorder: Assessment and treatment implications. Behav Res Ther 62, 74–87 (2014).

[6]. Alloy, L. B., Olino, T., Freed, R. D. & Nusslock, R. Role of Reward Sensitivity and Processing in Major Depressive and Bipolar Spectrum Disorders. Behav Ther 47, 600–621 (2016).

[7]. Bertocci, M. A. et al. The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder. Mol Psychiatr 26, 4137–4145 (2021).

[8]. Smucny, J. et al. Schizophrenia and bipolar disorder are associated with opposite brain reward anticipation-associated response. Neuropsychopharmacol 46, 1152–1160 (2021).

[9]. Berghorst, L. H. et al. Stress and reward processing in bipolar disorder: a functional magnetic resonance imaging study. Bipolar Disord 18, 602–611 (2016).

[10]. Ibanez, A. et al. The Neural Basis of Decision-Making and Reward Processing in Adults with Euthymic Bipolar Disorder or Attention-Deficit/Hyperactivity Disorder (ADHD). Plos One 7, e37306 (2012).

[11]. Cléry-Melin, M.-L., Jollant, F. & Gorwood, P. Reward systems and cognitions in Major Depressive Disorder. Cns Spectrums 24, 64–77 (2019).

[12]. Luking, K. R., Pagliaccio, D., Luby, J. L. & Barch, D. M. Reward Processing and Risk for Depression Across Development. Trends Cogn Sci 20, 456–468 (2016).

[13]. Rupprechter, S., Stankevicius, A., Huys, Q. J. M., Series, P. & Steele, J. D. Abnormal reward valuation and event-related connectivity in unmedicated major depressive disorder. Psychol Med 51, 795–803 (2021).

[14]. Redlich, R. et al. Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study. Neuropsychopharmacol 40, 2623–2631 (2015).

[15]. Satterthwaite, T. D. et al. Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression. Neuropsychopharmacol 40, 2258–2268 (2015).

[16]. Hanford, L. C. et al. The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder. Plos One 14, e0226135 (2019).

[17]. Bart, C. P., Titone, M. K., Ng, T. H., Nusslock, R. & Alloy, L. B. Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration. Clin Psychol Rev 87, 102035 (2021).