
Current progress in micro/nanofluidic chips and applications in cancer research and therapy
- 1 National University of Singapore
* Author to whom correspondence should be addressed.
Abstract
Micro/nanofluidic chips have set a new stage for cancer research and therapy, revolutionising the way we detect, diagnose, and treat this formidable disease. This paper provides an overview of the basic properties of micro/nanofluidic chips and current progress in the utilization of micro/nanofluidic chips in the realm of cancer. Their application in DNA and protein analysis, their role in cancer modelling and drug testing, and their innovative use in drug-eluting devices for cancer immunotherapy are discussed. The advantages and limitations of these technologies are evaluated, shedding light on the challenges and opportunities. Having the potential for earlier and more accurate diagnosis, novel therapy methods with better outcomes and less side-effects, more advancement and further breakthroughs can be anticipated in tackling tumours with micro/nanofluidic chips. In future development, it is suggested that combinations of such chips and various other emerging technologies can be attempted and explored for inventing more innovative and functional micro/nanofluidic devices, making a difference in the field of cancer research and therapy. Simultaneously, more improvement such as enhancing reproducibility and affordability is also necessarily required to realise the clinical trial, mass production, commercialisation of these chips.
Keywords
Nanotechnology, micro/nanofluidic chip, genomics, tumour modelling, immunotherapy
[1]. Mosleh-Shirazi, S., Abbasi, M., Moaddeli, M. reza, Vaez, A., Shafiee, M., Kasaee, S. R., Amani, A. M., & Hatam, S. (2022). Nanotechnology advances in the detection and treatment of cancer: An overview. Nanotheranostics, 6(4), 400–423.
[2]. Wang, M., Huang, P.-J., Kameoka, J., Chou, C.-K., Tsou, P.-H., Yamaguchi, H., & Hung, M.-C. (2016). Nanofluidic strategies for cancer research. Nanofluidics, 114–149.
[3]. Sztandera, K., Gorzkiewicz, M., & Klajnert-Maculewicz, B. (2018). Gold nanoparticles in cancer treatment. Molecular Pharmaceutics, 16(1), 1–23.
[4]. Kavokine, N., Netz, R. R., & Bocquet, L. (2021). Fluids at the nanoscale: From Continuum to Subcontinuum Transport. Annual Review of Fluid Mechanics, 53(1), 377–410.
[5]. Yamamoto, K., Ota, N., & Tanaka, Y. (2020). Nanofluidic devices and applications for biological analyses. Analytical Chemistry, 93(1), 332-349.
[6]. Guo, Q., Zhang, L., Liu, J., Li, Z., Li, J., Zhou, W., Wang, H., Li, J., Liu, D., Yu, X., & Zhang, J. (2021). Multifunctional microfluidic chip for cancer diagnosis and treatment. Nanotheranostics, 5(1), 73–89.
[7]. Juarez-Martinez, G., Chiolerio, A., Allia, P., Poggio, M., Degen, C. L., Zhang, L., Nelson, B. J., Dong, L., Iwamoto, M., Buehler, M. J., Bratzel, G., Mohamed, F. A., Doble, N., Govil, A., Bita, I., Gusev, E., Huang, J.-T., Lee, K.-Y., Hsu, H.-J., … Ferrari, M. (2012). Micro- and Nanofluidic devices for Medical Diagnostics. Encyclopedia of Nanotechnology, 1375–1375.
[8]. Abgrall, P., & Nguyen, N. T. (2008). Nanofluidic devices and their applications. Analytical Chemistry, 80(7), 2326–2341.
[9]. Basak, R., Liu, F., Qureshi, S., Gupta, N., Zhang, C., de Vries, R., van Kan, J. A., Dheen, S. T., & van der Maarel, J. R. (2019). Linearization and labeling of single-stranded DNA for optical sequence analysis. The Journal of Physical Chemistry Letters, 10(3), 316–321.
[10]. Carvalho, V., Teixeira , S. de F. C. F., & Ribeiro, J. (2022). Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications.
[11]. Chua, C. Y., Jain, P., Susnjar, A., Rhudy, J., Folci, M., Ballerini, A., Gilbert, A., Singh, S., Bruno, G., Filgueira, C. S., Yee, C., Butler, E. B., & Grattoni, A. (2018). Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer. Journal of Controlled Release, 285, 23–34.
[12]. Liu, H., Davila Gonzalez, D., Viswanath, D. I., Vander Pol, R. S., Saunders, S. Z., Di Trani, N., Xu, Y., Zheng, J., Chen, S., Chua, C. Y., & Grattoni, A. (2023). Sustained intratumoral administration of agonist CD40 antibody overcomes immunosuppressive tumor microenvironment in pancreatic cancer. Advanced Science, 10(9).
[13]. Ko, J., Bhagwat, N., Yee, S. S., Ortiz, N., Sahmoud, A., Black, T., ... & Issadore, D. (2017). Combining machine learning and nanofluidic technology to diagnose pancreatic cancer using exosomes. ACS nano, 11(11), 11182-11193.Kunze K 2003 T-duality and Penrose limits of spatially homogeneous and inhomogeneous cosmologies Phys. Rev. D 68 063517 (Preprint gr-qc/0303038)
Cite this article
Li,Y. (2024). Current progress in micro/nanofluidic chips and applications in cancer research and therapy. Applied and Computational Engineering,61,17-23.
Data availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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