Application of self-assembly technology in the field of medicine

Research Article
Open access

Application of self-assembly technology in the field of medicine

Yizhe Bai 1*
  • 1 School of Materials Science and Engineering, Shanghai University, Shanghai, China, 201615    
  • *corresponding author BYZ2182@outlook.com
Published on 21 July 2023 | https://doi.org/10.54254/2755-2721/7/20230375
ACE Vol.7
ISSN (Print): 2755-273X
ISSN (Online): 2755-2721
ISBN (Print): 978-1-915371-61-4
ISBN (Online): 978-1-915371-62-1

Abstract

In recent years, the preparation of polymer micelles and self-assembled nanomaterials by amphiphilic block copolymers has attracted great interest and has now become a research hotspot in the field of polymer science. Based on the self-assembly technology of block compounds, this paper introduces how self-assembly technology can play a role in the clinical environment, especially for the treatment of tumors and cancer, and controlled drug release. Finally, the related challenges and opportunities for self-assembled nanoparticles are described and prospected. Currently, although block copolymers have great performance in many fields, it is difficult to summarize one or a series of regular methods for the preparation of block copolymers and we also did not find a preparation method suitable for industrial production and wide application.

Keywords:

block copolymer, self-assembly, controlled drug release, polymeric micelle, nanomedicines

Bai,Y. (2023). Application of self-assembly technology in the field of medicine. Applied and Computational Engineering,7,104-112.
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References

[1]. Freddie, Bray, Jacques, Ferlay, Isabelle, & Soerjomataram, et al. (2018). Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians.

[2]. Rui-Mei, Feng, Yi-Nan, Zong, Su-Mei, & Cao, et al. (2019). Current cancer situation in china: good or bad news from the 2018 global cancer statistics?. Cancer communications (London, England).

[3]. C., Thomas, Griffiths, MD, Richard, & H., et al. (1972). Advanced ovarian cancer: primary treatment with surgery, radiotherapy, and chemotherapy. Cancer.

[4]. Jiang, X. , Li, L. , Jia, L. , & Zhuo, R. (2011). Reduction-responsive polymeric micelles for anticancer drug delivery[J]. Journal of Controlled Release, 152(1), e36-e37.

[5]. Matsen MW. & Bates FS. (1997). BLOCK COPOLYMER MICROSTRUCTURES IN THE INTERMEDIATE-SEGREGATION REGIME[J]. The Journal of Chemical Physics(6).

[6]. Chen, H. Y. , & Fredrickson, G. H. (2002). Morphologies of abc triblock copolymer thin films. Journal of Chemical Physics, 116(3), 1137-1146.

[7]. Li, C. , Li, Q. , Kaneti, Y. V. , Hou, D. , Yamauchi, Y. , & Mai, Y. (2020). Self-assembly of block copolymers towards mesoporous materials for energy storage and conversion systems. Chemical Society Reviews, 49.

[8]. Qin, S. Y., Zhang, A. Q., Cheng, S. X., Rong, L., & Zhang, X. Z. (2017). Drug self-delivery systems for cancer therapy. Biomaterials, 112, 234-247.

[9]. Song, X. , Zhang, R. , Liang, C. , Chen, Q. , Gong, H. , & Liu, Z. (2015). Nano-assemblies of j-aggregates based on a nir dye as a multifunctional drug carrier for combination cancer therapy - sciencedirect. Biomaterials, 57, 84-92.

[10]. Ma, M., Xing, P., Xu, S., Li, S., Chu, X., & Hao, A. (2014). Reversible pH-responsive helical nanoribbons formed using camptothecin. RSC Advances, 4(80), 42372-42375.

[11]. Hu, X., Zhai, S., Liu, G., Xing, D., Liang, H., & Liu, S. (2018). Concurrent drug unplugging and permeabilization of polyprodrug‐gated crosslinked vesicles for cancer combination chemotherapy. Advanced Materials, 30(21), 1706307.

[12]. Zhang, S., Guo, W., Wei, J., Li, C., Liang, X. J., & Yin, M. (2017). Terrylenediimide-based intrinsic theranostic nanomedicines with high photothermal conversion efficiency for photoacoustic imaging-guided cancer therapy. ACS nano, 11(4), 3797-3805.

[13]. Ji, Y., Xiao, Y., Xu, L., He, J., Qian, C., Li, W., ... & Chen, Z. (2018). Drug‐bearing supramolecular MMP inhibitor nanofibers for inhibition of metastasis and growth of liver cancer. Advanced Science, 5(8), 1700867.

[14]. Chen, Q. , Wang, C. , Zhan, Z. , He, W. , & Zhuang, L. (2014). Near-infrared dye bound albumin with separated imaging and therapy wavelength channels for imaging-guided photothermal therapy. Biomaterials, 35(28), 8206-8214.

[15]. Zou, Q. , Abbas, M. , Zhao, L. , Li, S. , & Yan, X. (2017). Biological photothermal nanodots based on self-assembly of peptide-porphyrin conjugates for antitumor therapy. Journal of the American Chemical Society, 139(5).

[16]. Kasai, H. , Murakami, T. , Ikuta, Y. , Koseki, Y. , & Hashida, M. (2012). Creation of pure nanodrugs and their anticancer properties. Angewandte Chemie International Edition, 51(41), 10315-10318.

[17]. Zhang, D., Zhang, J., Li, Q., Tian, H., Zhang, N., Li, Z., & Luan, Y. (2018). pH-and enzyme-sensitive IR820–paclitaxel conjugate self-assembled nanovehicles for near-infrared fluorescence imaging-guided chemo–photothermal therapy. ACS applied materials & interfaces, 10(36), 30092-30102.

[18]. Sun, M., Qian, Q., Shi, L., Xu, L., Liu, Q., Zhou, L., ... & Yan, D. (2020). Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs. Science China Chemistry, 63(1), 35-41.

[19]. Zheng YR Kogularamanan,Johnstone Timothy C... & Lippard Stephen J.(2014).Pt(IV) prodrugs designed to bind non-covalently to human serum albumin for drug delivery. Journal of the American Chemical Society(24). doi:10.1021/ja5038269.

[20]. Zhou, Jiong, Guocan, Huang, & Feihe. (2017). Supramolecular chemotherapy based on host-guest molecular recognition: a novel strategy in the battle against cancer with a bright future. Chemical Society Reviews, 46(22).

[21]. Jiang, Q. , Song, C. , Nangreave, J. , Liu, X. , Lin, L. & Qiu, D. , et al. (2012). Dna origami as a carrier for circumvention of drug resistance. Journal of the American Chemical Society.

[22]. Gros, D. C. L. , Ringsdorf, H. , & Schupp, D. C. H. (2010). Polymeric antitumor agents on a molecular and on a cellular level?. Angewandte Chemie International Edition, 20(4), 305-325.

[23]. Dan, P. , Karp, J. M. , Hong, S. , Farokhzad, O. C. , & Langer, R. (2020). Nanocarriers as an Emerging Platform for Cancer Therapy.

[24]. Ni, YP, & Chen, JD. (2008). Research progress on supramolecular polymers. China Synthetic Resin and Plastics, 25(5), 5.

[25]. Soga, O. , Nostrum, C. F. V. , Fens, M. , Rijcken, C. J. F. , Schiffelers, R. M. , & Storm, G. , et al. (2005). Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery. Journal of Controlled Release Official Journal of the Controlled Release Society, 103(2), 341-353.

[26]. Blanco, E. , Kessinger, C. W. , Sumer, B. D. , & Gao, J. (2009). Multifunctional micellar nanomedicine for cancer therapy. Experimental Biology & Medicine, 234(2), 123-131.

[27]. Lu, J. , An, Y. L. , Huang, N. , Chen, X. , & Shi, L. Q. (2007). Controlled release for drug by complex micelles of block copolymers with tunable channels. Chemical Journal of Chinese Universities.

[28]. Yu, J. M., Dubois, P., & Jérôme, R. (1996). Poly [alkyl methacrylate-b-butadiene-b-alkyl methacrylate] triblock copolymers: Synthesis, morphology, and mechanical properties at high temperatures. Macromolecules, 29(26), 8362-8370.

[29]. Ishizu, K., Minematsu, S., & Fukutomi, T. (1991). Synthesis and blend morphology of BA/BC‐type binary graft copolymers composed of polyelectrolyte trunks. Journal of applied polymer science, 43(11), 2107-2114.

[30]. Lysenko EA.,Eisenberg A., Kabanov VA., Kabanov AV. & Bronich TK. (1998). Block ionomer complexes from polystyrene-block-polyacrylate anions and N-cetylpyridinium cations. Macromolecules(14).

[31]. Liu, S., Pan, Q., Xie, J., & Jiang, M. (2000). Intermacromolecular complexes due to specific interactions. 12. Graft-like hydrogen bonding complexes based on pyridyl-containing polymers and end-functionalized polystyrene oligomers. Polymer, 41(18), 6919-6929.

[32]. Virtanen Janne & Baron Caroline. (2000). Grafting of Poly(N-isopropylacrylamide) with Poly(ethylene oxide) under Various Reaction Conditions. Macromolecules(2).

[33]. Qiu, X., & Wu, C. (1997). Study of the core — shell nanoparticle formed through the “coil-to-globule” transition of poly (N-isopropylacrylamide) grafted with poly (ethylene oxide). Macromolecules, 30(25), 7921-7926.

[34]. Chi, Wu, Xingping, & Qiu. (1998). Single chain core-shell nanostructure. Physical Review Letters, 80(3), 620–622.

[35]. Wang, G. M., Liu, W. B., & Cai, Q. (2008). Preparation and its stability of thermo — sensitive block copolymer nano-micelles. J Func Polym(Chinese), 21, 242-248.

[36]. Yan, JH. , & Zhao, YB. (2009). “Living” Radical Polymerization of Amphiphilic Copolymer by ATRP Process. Journal of Henan University(Natural Science), 39(5), 5.


Cite this article

Bai,Y. (2023). Application of self-assembly technology in the field of medicine. Applied and Computational Engineering,7,104-112.

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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 3rd International Conference on Materials Chemistry and Environmental Engineering (CONF-MCEE 2023), Part II

ISBN:978-1-915371-61-4(Print) / 978-1-915371-62-1(Online)
Editor:Ioannis Spanopoulos, Niaz Ahmed, Sajjad Seifi Mofarah
Conference website: https://www.confmcee.org/
Conference date: 18 March 2023
Series: Applied and Computational Engineering
Volume number: Vol.7
ISSN:2755-2721(Print) / 2755-273X(Online)

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References

[1]. Freddie, Bray, Jacques, Ferlay, Isabelle, & Soerjomataram, et al. (2018). Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians.

[2]. Rui-Mei, Feng, Yi-Nan, Zong, Su-Mei, & Cao, et al. (2019). Current cancer situation in china: good or bad news from the 2018 global cancer statistics?. Cancer communications (London, England).

[3]. C., Thomas, Griffiths, MD, Richard, & H., et al. (1972). Advanced ovarian cancer: primary treatment with surgery, radiotherapy, and chemotherapy. Cancer.

[4]. Jiang, X. , Li, L. , Jia, L. , & Zhuo, R. (2011). Reduction-responsive polymeric micelles for anticancer drug delivery[J]. Journal of Controlled Release, 152(1), e36-e37.

[5]. Matsen MW. & Bates FS. (1997). BLOCK COPOLYMER MICROSTRUCTURES IN THE INTERMEDIATE-SEGREGATION REGIME[J]. The Journal of Chemical Physics(6).

[6]. Chen, H. Y. , & Fredrickson, G. H. (2002). Morphologies of abc triblock copolymer thin films. Journal of Chemical Physics, 116(3), 1137-1146.

[7]. Li, C. , Li, Q. , Kaneti, Y. V. , Hou, D. , Yamauchi, Y. , & Mai, Y. (2020). Self-assembly of block copolymers towards mesoporous materials for energy storage and conversion systems. Chemical Society Reviews, 49.

[8]. Qin, S. Y., Zhang, A. Q., Cheng, S. X., Rong, L., & Zhang, X. Z. (2017). Drug self-delivery systems for cancer therapy. Biomaterials, 112, 234-247.

[9]. Song, X. , Zhang, R. , Liang, C. , Chen, Q. , Gong, H. , & Liu, Z. (2015). Nano-assemblies of j-aggregates based on a nir dye as a multifunctional drug carrier for combination cancer therapy - sciencedirect. Biomaterials, 57, 84-92.

[10]. Ma, M., Xing, P., Xu, S., Li, S., Chu, X., & Hao, A. (2014). Reversible pH-responsive helical nanoribbons formed using camptothecin. RSC Advances, 4(80), 42372-42375.

[11]. Hu, X., Zhai, S., Liu, G., Xing, D., Liang, H., & Liu, S. (2018). Concurrent drug unplugging and permeabilization of polyprodrug‐gated crosslinked vesicles for cancer combination chemotherapy. Advanced Materials, 30(21), 1706307.

[12]. Zhang, S., Guo, W., Wei, J., Li, C., Liang, X. J., & Yin, M. (2017). Terrylenediimide-based intrinsic theranostic nanomedicines with high photothermal conversion efficiency for photoacoustic imaging-guided cancer therapy. ACS nano, 11(4), 3797-3805.

[13]. Ji, Y., Xiao, Y., Xu, L., He, J., Qian, C., Li, W., ... & Chen, Z. (2018). Drug‐bearing supramolecular MMP inhibitor nanofibers for inhibition of metastasis and growth of liver cancer. Advanced Science, 5(8), 1700867.

[14]. Chen, Q. , Wang, C. , Zhan, Z. , He, W. , & Zhuang, L. (2014). Near-infrared dye bound albumin with separated imaging and therapy wavelength channels for imaging-guided photothermal therapy. Biomaterials, 35(28), 8206-8214.

[15]. Zou, Q. , Abbas, M. , Zhao, L. , Li, S. , & Yan, X. (2017). Biological photothermal nanodots based on self-assembly of peptide-porphyrin conjugates for antitumor therapy. Journal of the American Chemical Society, 139(5).

[16]. Kasai, H. , Murakami, T. , Ikuta, Y. , Koseki, Y. , & Hashida, M. (2012). Creation of pure nanodrugs and their anticancer properties. Angewandte Chemie International Edition, 51(41), 10315-10318.

[17]. Zhang, D., Zhang, J., Li, Q., Tian, H., Zhang, N., Li, Z., & Luan, Y. (2018). pH-and enzyme-sensitive IR820–paclitaxel conjugate self-assembled nanovehicles for near-infrared fluorescence imaging-guided chemo–photothermal therapy. ACS applied materials & interfaces, 10(36), 30092-30102.

[18]. Sun, M., Qian, Q., Shi, L., Xu, L., Liu, Q., Zhou, L., ... & Yan, D. (2020). Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs. Science China Chemistry, 63(1), 35-41.

[19]. Zheng YR Kogularamanan,Johnstone Timothy C... & Lippard Stephen J.(2014).Pt(IV) prodrugs designed to bind non-covalently to human serum albumin for drug delivery. Journal of the American Chemical Society(24). doi:10.1021/ja5038269.

[20]. Zhou, Jiong, Guocan, Huang, & Feihe. (2017). Supramolecular chemotherapy based on host-guest molecular recognition: a novel strategy in the battle against cancer with a bright future. Chemical Society Reviews, 46(22).

[21]. Jiang, Q. , Song, C. , Nangreave, J. , Liu, X. , Lin, L. & Qiu, D. , et al. (2012). Dna origami as a carrier for circumvention of drug resistance. Journal of the American Chemical Society.

[22]. Gros, D. C. L. , Ringsdorf, H. , & Schupp, D. C. H. (2010). Polymeric antitumor agents on a molecular and on a cellular level?. Angewandte Chemie International Edition, 20(4), 305-325.

[23]. Dan, P. , Karp, J. M. , Hong, S. , Farokhzad, O. C. , & Langer, R. (2020). Nanocarriers as an Emerging Platform for Cancer Therapy.

[24]. Ni, YP, & Chen, JD. (2008). Research progress on supramolecular polymers. China Synthetic Resin and Plastics, 25(5), 5.

[25]. Soga, O. , Nostrum, C. F. V. , Fens, M. , Rijcken, C. J. F. , Schiffelers, R. M. , & Storm, G. , et al. (2005). Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery. Journal of Controlled Release Official Journal of the Controlled Release Society, 103(2), 341-353.

[26]. Blanco, E. , Kessinger, C. W. , Sumer, B. D. , & Gao, J. (2009). Multifunctional micellar nanomedicine for cancer therapy. Experimental Biology & Medicine, 234(2), 123-131.

[27]. Lu, J. , An, Y. L. , Huang, N. , Chen, X. , & Shi, L. Q. (2007). Controlled release for drug by complex micelles of block copolymers with tunable channels. Chemical Journal of Chinese Universities.

[28]. Yu, J. M., Dubois, P., & Jérôme, R. (1996). Poly [alkyl methacrylate-b-butadiene-b-alkyl methacrylate] triblock copolymers: Synthesis, morphology, and mechanical properties at high temperatures. Macromolecules, 29(26), 8362-8370.

[29]. Ishizu, K., Minematsu, S., & Fukutomi, T. (1991). Synthesis and blend morphology of BA/BC‐type binary graft copolymers composed of polyelectrolyte trunks. Journal of applied polymer science, 43(11), 2107-2114.

[30]. Lysenko EA.,Eisenberg A., Kabanov VA., Kabanov AV. & Bronich TK. (1998). Block ionomer complexes from polystyrene-block-polyacrylate anions and N-cetylpyridinium cations. Macromolecules(14).

[31]. Liu, S., Pan, Q., Xie, J., & Jiang, M. (2000). Intermacromolecular complexes due to specific interactions. 12. Graft-like hydrogen bonding complexes based on pyridyl-containing polymers and end-functionalized polystyrene oligomers. Polymer, 41(18), 6919-6929.

[32]. Virtanen Janne & Baron Caroline. (2000). Grafting of Poly(N-isopropylacrylamide) with Poly(ethylene oxide) under Various Reaction Conditions. Macromolecules(2).

[33]. Qiu, X., & Wu, C. (1997). Study of the core — shell nanoparticle formed through the “coil-to-globule” transition of poly (N-isopropylacrylamide) grafted with poly (ethylene oxide). Macromolecules, 30(25), 7921-7926.

[34]. Chi, Wu, Xingping, & Qiu. (1998). Single chain core-shell nanostructure. Physical Review Letters, 80(3), 620–622.

[35]. Wang, G. M., Liu, W. B., & Cai, Q. (2008). Preparation and its stability of thermo — sensitive block copolymer nano-micelles. J Func Polym(Chinese), 21, 242-248.

[36]. Yan, JH. , & Zhao, YB. (2009). “Living” Radical Polymerization of Amphiphilic Copolymer by ATRP Process. Journal of Henan University(Natural Science), 39(5), 5.