The Integrative Research Approach of Anorexia Nervosa

Research Article
Open access

The Integrative Research Approach of Anorexia Nervosa

Qiuwei Ding 1*
  • 1 The Peddie School    
  • *corresponding author qding-24@peddie.org
Published on 14 September 2023 | https://doi.org/10.54254/2753-7048/9/20230062
LNEP Vol.9
ISSN (Print): 2753-7056
ISSN (Online): 2753-7048
ISBN (Print): 978-1-915371-99-7
ISBN (Online): 978-1-83558-000-4

Abstract

The prevalence of eating disorders has led to extensive studies on different aspects of this mental illness, ranging from the underlying genetics to animal models. However, given the distinct research methods used in investigations, there are little integration and cross-check across the disciplines, thus withholding the potential unification on the understanding of eating disorders. The aims of this review is to verify the findings from various levels, and also to reach the purpose of discovering existing patterns across the levels and encouraging more cross-level integrative approach. Therefore, this paper reviews the progresses made in fields of genetics, neurobiology, and animal models, and concludes that certain gene variants, brain abnormalities and animal models are associated with eating disorders. It brings forth gene variants identified from an extensive genetic research and points out the possibility of using neuroimaging and then animal models to corroborate the association for future pharmaceutical purposes. It also encourages better communication and cross validation across the fields on technological advances and new findings to better understand eating disorders.

Keywords:

eating disorders, integrative approach, neurobiology, genetics, animal model

Ding,Q. (2023). The Integrative Research Approach of Anorexia Nervosa. Lecture Notes in Education Psychology and Public Media,9,59-65.
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References

[1]. Treasure, J., Duarte, T. A., & Schmidt, U. (2020). Eating disorders. The Lancet, 395(10227), 899–911. https://doi.org/10.1016/S0140-6736(20)30059-3

[2]. Cuesto, G., Everaerts, C., León, L. G., & Acebes, A. (2017). Molecular bases of anorexia nervosa, bulimia nervosa and binge eating disorder: Shedding light on the darkness. Journal of Neurogenetics, 31(4), 266–287. https://doi.org/10.1080/01677063.2017.1353092

[3]. Bulik, C. M., Coleman, J. R. I., Hardaway, J. A., Breithaupt, L., Watson, H. J., Bryant, C. D., & Breen, G. (2022). Genetics and neurobiology of eating disorders. Nature Neuroscience, 25(5), 543–554. https://doi.org/10.1038/s41593-022-01071-z

[4]. Uffelmann, E., Huang, Q. Q., Munung, N. S., de Vries, J., Okada, Y., Martin, A. R., Martin, H. C., Lappalainen, T., & Posthuma, D. (2021). Genome-wide association studies. Nature Reviews Methods Primers, 1(1), 59. https://doi.org/10.1038/s43586-021-00056-9

[5]. Akbari, P., Gilani, A., Sosina, O., Kosmicki, J. A., Khrimian, L., Fang, Y.-Y., Persaud, T., Garcia, V., Sun, D., Li, A., Mbatchou, J., Locke, A. E., Benner, C., Verweij, N., Lin, N., Hossain, S., Agostinucci, K., Pascale, J. V., Dirice, E., … Lotta, L. A. (2021). Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity. Science, 373(6550), eabf8683. https://doi.org/10.1126/science.abf8683

[6]. Watson, H. J., Palmos, A. B., Hunjan, A., Baker, J. H., Yilmaz, Z., & Davies, H. L. (2021). Genetics of eating disorders in the genome-wide era. Psychological Medicine, 51(13), 2287–2297. https://doi.org/10.1017/S0033291720005474

[7]. Song, W., Wang, W., Yu, S., & Lin, G. N. (2021). Dissection of the Genetic Association between Anorexia Nervosa and Obsessive–Compulsive Disorder at the Network and Cellular Levels. Genes, 12(4), 491. https://doi.org/10.3390/genes12040491

[8]. Frank, G. K. W., Shott, M. E., & DeGuzman, M. C. (2019). The Neurobiology of Eating Disorders. Child and Adolescent Psychiatric Clinics of North America, 28(4), 629–640. https://doi.org/10.1016/j.chc.2019.05.007

[9]. Su, T., Gong, J., Tang, G., Qiu, S., Chen, P., Chen, G., Wang, J., Huang, L., & Wang, Y. (2021). Structural and functional brain alterations in anorexia nervosa:A multimodal meta‐analysis of neuroimaging studies. Human Brain Mapping, 42(15), 5154–5169. https://doi.org/10.1002/hbm.25602

[10]. Bartholdy, S., Dalton, B., O’Daly, O. G., Campbell, I. C., & Schmidt, U. (2016). A systematic review of the relationship between eating, weight and inhibitory control using the stop signal task. Neuroscience & Biobehavioral Reviews, 64, 35–62. https://doi.org/10.1016/j.neubiorev.2016.02.010

[11]. Kaye, W. H., Wagner, A., Fudge, J. L., & Paulus, M. (2010). Neurocircuity of Eating Disorders. In R. A. H. Adan & W. H. Kaye (ED.), Behavioral Neurobiology of Eating Disorders (Vol. 6, pp. 37–57). Springer Berlin Heidelberg. https://doi.org/10.1007/7854_2010_85

[12]. Bischoff-Grethe, A., McCurdy, D., Grenesko-Stevens, E., (Zoe) Irvine, L. E., Wagner, A., Wendy Yau, W.-Y., Fennema-Notestine, C., Wierenga, C. E., Fudge, J. L., Delgado, M. R., & Kaye, W. H. (2013). Altered brain response to reward and punishment in adolescents with Anorexia nervosa. Psychiatry Research: Neuroimaging, 214(3), 331–340. https://doi.org/10.1016/j.pscychresns.2013.07.004

[13]. Decker, J. H., Figner, B., & Steinglass, J. E. (2015). On Weight and Waiting: Delay Discounting in Anorexia Nervosa Pretreatment and Posttreatment. Biological Psychiatry, 78(9), 606–614. https://doi.org/10.1016/j.biopsych.2014.12.016

[14]. Frank, G. K. W., Reynolds, J. R., Shott, M. E., Jappe, L., Yang, T. T., Tregellas, J. R., & O’Reilly, R. C. (2012). Anorexia Nervosa and Obesity are Associated with Opposite Brain Reward Response. Neuropsychopharmacology, 37(9), 2031–2046. https://doi.org/10.1038/npp.2012.51

[15]. DeGuzman, M., Shott, M. E., Yang, T. T., Riederer, J., & Frank, G. K. W. (2017). Association of Elevated Reward Prediction Error Response With Weight Gain in Adolescent Anorexia Nervosa. American Journal of Psychiatry, 174(6), 557–565. https://doi.org/10.1176/appi.ajp.2016.16060671

[16]. West, R., Choi, P., & Travers, S. (2010). The influence of negative affect on the neural correlates of cognitive control. International Journal of Psychophysiology, 76(2), 107–117. https://doi.org/10.1016/j.ijpsycho.2010.03.002

[17]. Wonderlich, J. A., Bershad, M., & Steinglass, J. E. (2021). Exploring Neural Mechanisms Related to Cognitive Control, Reward, and Affect in Eating Disorders: A Narrative Review of FMRI Studies. Neuropsychiatric Disease and Treatment, Volume 17, 2053–2062. https://doi.org/10.2147/NDT.S282554

Cite this article

Ding,Q. (2023). The Integrative Research Approach of Anorexia Nervosa. Lecture Notes in Education Psychology and Public Media,9,59-65.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the International Conference on Social Psychology and Humanity Studies

ISBN：978-1-915371-99-7(Print) / 978-1-83558-000-4(Online)
Editor：Faisalabad Matilde Lafuente-Lechuga, Muhammad Idrees
Conference website: https://www.icsphs.org/
Conference date: 24 April 2023
Series: Lecture Notes in Education Psychology and Public Media
Volume number: Vol.9
ISSN：2753-7048(Print) / 2753-7056(Online)

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References

[1]. Treasure, J., Duarte, T. A., & Schmidt, U. (2020). Eating disorders. The Lancet, 395(10227), 899–911. https://doi.org/10.1016/S0140-6736(20)30059-3

[2]. Cuesto, G., Everaerts, C., León, L. G., & Acebes, A. (2017). Molecular bases of anorexia nervosa, bulimia nervosa and binge eating disorder: Shedding light on the darkness. Journal of Neurogenetics, 31(4), 266–287. https://doi.org/10.1080/01677063.2017.1353092

[3]. Bulik, C. M., Coleman, J. R. I., Hardaway, J. A., Breithaupt, L., Watson, H. J., Bryant, C. D., & Breen, G. (2022). Genetics and neurobiology of eating disorders. Nature Neuroscience, 25(5), 543–554. https://doi.org/10.1038/s41593-022-01071-z

[4]. Uffelmann, E., Huang, Q. Q., Munung, N. S., de Vries, J., Okada, Y., Martin, A. R., Martin, H. C., Lappalainen, T., & Posthuma, D. (2021). Genome-wide association studies. Nature Reviews Methods Primers, 1(1), 59. https://doi.org/10.1038/s43586-021-00056-9

[5]. Akbari, P., Gilani, A., Sosina, O., Kosmicki, J. A., Khrimian, L., Fang, Y.-Y., Persaud, T., Garcia, V., Sun, D., Li, A., Mbatchou, J., Locke, A. E., Benner, C., Verweij, N., Lin, N., Hossain, S., Agostinucci, K., Pascale, J. V., Dirice, E., … Lotta, L. A. (2021). Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity. Science, 373(6550), eabf8683. https://doi.org/10.1126/science.abf8683

[6]. Watson, H. J., Palmos, A. B., Hunjan, A., Baker, J. H., Yilmaz, Z., & Davies, H. L. (2021). Genetics of eating disorders in the genome-wide era. Psychological Medicine, 51(13), 2287–2297. https://doi.org/10.1017/S0033291720005474

[7]. Song, W., Wang, W., Yu, S., & Lin, G. N. (2021). Dissection of the Genetic Association between Anorexia Nervosa and Obsessive–Compulsive Disorder at the Network and Cellular Levels. Genes, 12(4), 491. https://doi.org/10.3390/genes12040491

[8]. Frank, G. K. W., Shott, M. E., & DeGuzman, M. C. (2019). The Neurobiology of Eating Disorders. Child and Adolescent Psychiatric Clinics of North America, 28(4), 629–640. https://doi.org/10.1016/j.chc.2019.05.007

[9]. Su, T., Gong, J., Tang, G., Qiu, S., Chen, P., Chen, G., Wang, J., Huang, L., & Wang, Y. (2021). Structural and functional brain alterations in anorexia nervosa:A multimodal meta‐analysis of neuroimaging studies. Human Brain Mapping, 42(15), 5154–5169. https://doi.org/10.1002/hbm.25602

[10]. Bartholdy, S., Dalton, B., O’Daly, O. G., Campbell, I. C., & Schmidt, U. (2016). A systematic review of the relationship between eating, weight and inhibitory control using the stop signal task. Neuroscience & Biobehavioral Reviews, 64, 35–62. https://doi.org/10.1016/j.neubiorev.2016.02.010

[11]. Kaye, W. H., Wagner, A., Fudge, J. L., & Paulus, M. (2010). Neurocircuity of Eating Disorders. In R. A. H. Adan & W. H. Kaye (ED.), Behavioral Neurobiology of Eating Disorders (Vol. 6, pp. 37–57). Springer Berlin Heidelberg. https://doi.org/10.1007/7854_2010_85

[12]. Bischoff-Grethe, A., McCurdy, D., Grenesko-Stevens, E., (Zoe) Irvine, L. E., Wagner, A., Wendy Yau, W.-Y., Fennema-Notestine, C., Wierenga, C. E., Fudge, J. L., Delgado, M. R., & Kaye, W. H. (2013). Altered brain response to reward and punishment in adolescents with Anorexia nervosa. Psychiatry Research: Neuroimaging, 214(3), 331–340. https://doi.org/10.1016/j.pscychresns.2013.07.004

[13]. Decker, J. H., Figner, B., & Steinglass, J. E. (2015). On Weight and Waiting: Delay Discounting in Anorexia Nervosa Pretreatment and Posttreatment. Biological Psychiatry, 78(9), 606–614. https://doi.org/10.1016/j.biopsych.2014.12.016

[14]. Frank, G. K. W., Reynolds, J. R., Shott, M. E., Jappe, L., Yang, T. T., Tregellas, J. R., & O’Reilly, R. C. (2012). Anorexia Nervosa and Obesity are Associated with Opposite Brain Reward Response. Neuropsychopharmacology, 37(9), 2031–2046. https://doi.org/10.1038/npp.2012.51

[15]. DeGuzman, M., Shott, M. E., Yang, T. T., Riederer, J., & Frank, G. K. W. (2017). Association of Elevated Reward Prediction Error Response With Weight Gain in Adolescent Anorexia Nervosa. American Journal of Psychiatry, 174(6), 557–565. https://doi.org/10.1176/appi.ajp.2016.16060671

[16]. West, R., Choi, P., & Travers, S. (2010). The influence of negative affect on the neural correlates of cognitive control. International Journal of Psychophysiology, 76(2), 107–117. https://doi.org/10.1016/j.ijpsycho.2010.03.002

[17]. Wonderlich, J. A., Bershad, M., & Steinglass, J. E. (2021). Exploring Neural Mechanisms Related to Cognitive Control, Reward, and Affect in Eating Disorders: A Narrative Review of FMRI Studies. Neuropsychiatric Disease and Treatment, Volume 17, 2053–2062. https://doi.org/10.2147/NDT.S282554

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