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The mechanism and design strategy of metal-organic frameworks in drug delivery
- 1 Material science and engineering, Taiyuan University of Technology, Taiyuan City, China
* Author to whom correspondence should be addressed.
Abstract
In the field of drug transport, the traditional drugs used for drug delivery are organic, inorganic, and complex. The organic polymer system and liposome system can have good biocompatibility, but the porosity of the polymer cannot be determined, and the medicine cannot be given a controlled release. In contrast, inorganic materials such as microporous zeolite and mesoporous silicon can achieve controlled drug release due to their definite relative porosity, but their drug-loading capacity and poor biocompatibility cannot be widely used for drug delivery. The materials of the new MOFs can synthesize the advantages of the two, with controlled drug release, biocompatibility, and good flexibility, that is, the performance of targeted drug delivery. This paper focuses on the mechanism of MOFs in drug transport and the related applications of MOFs in transporting small molecules, macromolecular drugs, and the surface modification methods of MOFs. The present paper concludes that MOFs can be widely used to transport macromolecules and small-molecule drugs and that drug targeting can be improved by surface modification. This paper hopes to provide suggestions and guidance for designing future MOF materials for DDS, to promote the application efficiency of nanomaterials in relevant aspects, and to achieve efficient, highly selective and highly stable drug delivery.
Keywords
MOFs, drug delivery, functionalization of MOF material
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Cite this article
Song,W. (2023). The mechanism and design strategy of metal-organic frameworks in drug delivery. Applied and Computational Engineering,7,188-195.
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Volume title: Proceedings of the 3rd International Conference on Materials Chemistry and Environmental Engineering (CONF-MCEE 2023), Part II
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