Early Nicotine Exposure and Opioid Abuse

Research Article
Open access

Early Nicotine Exposure and Opioid Abuse

Ziping Xu 1*
  • 1 Guangzhou University    
  • *corresponding author Iris.ZipingXu@e.gzhu.edu.cn
Published on 26 October 2023 | https://doi.org/10.54254/2753-7048/14/20230984
LNEP Vol.14
ISSN (Print): 2753-7056
ISSN (Online): 2753-7048
ISBN (Print): 978-1-83558-053-0
ISBN (Online): 978-1-83558-054-7

Abstract

Over the last few years, the number of opioid-related deaths has been skyrocketing across racial, age, and gender groups in the United States. Researchers have found that continuous exposure to nicotine-containing substances among teenagers increases the likelihood of opioid addiction during adulthood. Hence, exposure to nicotine remains an essential factor associated with opioid use. Early Nicotine Exposure and Opioid Abuse is the central theme of this study. The study yielded several noteworthy findings, including the following: Upon consumption, nicotine rapidly enters the bloodstream and binds to specific nicotinic acetylcholine receptors in the brain, resulting in the release of dopamine, a neurotransmitter responsible for the pleasurable and rewarding effects of nicotine use. Significantly, increased dependence on nicotine is strongly associated with heightened pain symptoms, which in turn exacerbate the likelihood of opioid use. To mitigate the risks of concurrent nicotine and opioid use, a comprehensive approach that addresses the root causes of addiction and prioritizes positive health outcomes for individuals and communities is needed. Hence, the importance of this study lies in its identification of key factors that inform the development of multifaceted interventions aimed at reducing the harms associated with nicotine and opioid use.

Keywords:

nicotine, opioid abuse, chronic pain

Xu,Z. (2023). Early Nicotine Exposure and Opioid Abuse. Lecture Notes in Education Psychology and Public Media,14,213-217.
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References

[1]. Ren, M., & Lotfipour, S. (2019). Nicotine gateway effects on adolescent substance use. Western Journal of Emergency Medicine, 20(5), 696.

[2]. National Institute on Drug Abuse. (2023, February 9). Overdose death rates. https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates

[3]. Loney, G. C., King, C. P., & Meyer, P. J. (2021). Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex. Scientific reports, 11(1), 3321.

[4]. Soucy, J. R., Burchett, G., Brady, R., Nichols, K., Breault, D. T., Koppes, A. N., & Koppes, R. A. (2021). Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure. Organs-on-a-Chip, 3, 100009.

[5]. Malanchini, M., Smith-Woolley, E., Ayorech, Z., Rimfeld, K., Krapohl, E., Vuoksimaa, E., ... & Plomin, R. (2019). Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium. Psychological medicine, 49(4), 646-654.

[6]. Mahajan, S. D., Homish, G. G., & Quisenberry, A. (2021). Multifactorial etiology of adolescent nicotine addiction: a review of the neurobiology of nicotine addiction and its implications for smoking cessation pharmacotherapy. Frontiers in Public Health, 9, 664748.

[7]. LaRowe, L. R., & Ditre, J. W. (2020). Pain, nicotine, and tobacco smoking: current state of the science. Pain, 161(8), 1688.

[8]. Cheatle, M. D., Compton, P. A., Dhingra, L., Wasser, T. E., & O’Brien, C. P. (2019). Development of the revised opioid risk tool to predict opioid use disorder in patients with chronic nonmalignant pain. The journal of pain, 20(7), 842-851.

[9]. Dydyk, A. M., Jain, N. K., & Gupta, M. (2022). Opioid use disorder. In StatPearls [Internet]. StatPearls Publishing.

[10]. Dao, J. M., McQuown, S. C., Loughlin, S. E., Belluzzi, J. D., & Leslie, F. M. (2011). Nicotine Alters Limbic Function in Adolescent Rat by a 5-HT1A Receptor Mechanism. Neuropsychopharmacology (New York, N.Y.), 36(7), 1319–1331. https://doi.org/10.1038/npp.2011.8

[11]. Rajabi, A., Dehghani, M., Shojaei, A., Farjam, M., & Motevalian, S. A. (2019). Association between tobacco smoking and opioid use: a meta-analysis. Addictive behaviors, 92, 225-235.

[12]. Morris, C. D., & Garver-Apgar, C. E. (2020). Nicotine and opioids: a call for co-treatment as the standard of care. The Journal of Behavioral Health Services & Research, 47, 601-613.

[13]. John, W. S., Zhu, H., Mannelli, P., Subramaniam, G. A., Schwartz, R. P., McNeely, J., & Wu, L. T. (2019). Prevalence and patterns of opioid misuse and opioid use disorder among primary care patients who use tobacco. Drug and alcohol dependence, 194, 468-475.

Cite this article

Xu,Z. (2023). Early Nicotine Exposure and Opioid Abuse. Lecture Notes in Education Psychology and Public Media,14,213-217.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 4th International Conference on Educational Innovation and Philosophical Inquiries

ISBN：978-1-83558-053-0(Print) / 978-1-83558-054-7(Online)
Editor：Javier Cifuentes-Faura, Enrique Mallen
Conference website: https://www.iceipi.org/
Conference date: 7 August 2023
Series: Lecture Notes in Education Psychology and Public Media
Volume number: Vol.14
ISSN：2753-7048(Print) / 2753-7056(Online)

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References

[1]. Ren, M., & Lotfipour, S. (2019). Nicotine gateway effects on adolescent substance use. Western Journal of Emergency Medicine, 20(5), 696.

[2]. National Institute on Drug Abuse. (2023, February 9). Overdose death rates. https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates

[3]. Loney, G. C., King, C. P., & Meyer, P. J. (2021). Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex. Scientific reports, 11(1), 3321.

[4]. Soucy, J. R., Burchett, G., Brady, R., Nichols, K., Breault, D. T., Koppes, A. N., & Koppes, R. A. (2021). Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure. Organs-on-a-Chip, 3, 100009.

[5]. Malanchini, M., Smith-Woolley, E., Ayorech, Z., Rimfeld, K., Krapohl, E., Vuoksimaa, E., ... & Plomin, R. (2019). Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium. Psychological medicine, 49(4), 646-654.

[6]. Mahajan, S. D., Homish, G. G., & Quisenberry, A. (2021). Multifactorial etiology of adolescent nicotine addiction: a review of the neurobiology of nicotine addiction and its implications for smoking cessation pharmacotherapy. Frontiers in Public Health, 9, 664748.

[7]. LaRowe, L. R., & Ditre, J. W. (2020). Pain, nicotine, and tobacco smoking: current state of the science. Pain, 161(8), 1688.

[8]. Cheatle, M. D., Compton, P. A., Dhingra, L., Wasser, T. E., & O’Brien, C. P. (2019). Development of the revised opioid risk tool to predict opioid use disorder in patients with chronic nonmalignant pain. The journal of pain, 20(7), 842-851.

[9]. Dydyk, A. M., Jain, N. K., & Gupta, M. (2022). Opioid use disorder. In StatPearls [Internet]. StatPearls Publishing.

[10]. Dao, J. M., McQuown, S. C., Loughlin, S. E., Belluzzi, J. D., & Leslie, F. M. (2011). Nicotine Alters Limbic Function in Adolescent Rat by a 5-HT1A Receptor Mechanism. Neuropsychopharmacology (New York, N.Y.), 36(7), 1319–1331. https://doi.org/10.1038/npp.2011.8

[11]. Rajabi, A., Dehghani, M., Shojaei, A., Farjam, M., & Motevalian, S. A. (2019). Association between tobacco smoking and opioid use: a meta-analysis. Addictive behaviors, 92, 225-235.

[12]. Morris, C. D., & Garver-Apgar, C. E. (2020). Nicotine and opioids: a call for co-treatment as the standard of care. The Journal of Behavioral Health Services & Research, 47, 601-613.

[13]. John, W. S., Zhu, H., Mannelli, P., Subramaniam, G. A., Schwartz, R. P., McNeely, J., & Wu, L. T. (2019). Prevalence and patterns of opioid misuse and opioid use disorder among primary care patients who use tobacco. Drug and alcohol dependence, 194, 468-475.

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