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Published on 6 December 2024
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Yang,W. (2024). Brain-computer interfaces in cognitive rehabilitation for Alzheimer's disease. Theoretical and Natural Science,64,163-169.
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Brain-computer interfaces in cognitive rehabilitation for Alzheimer's disease

Wanning Yang *,1,
  • 1 School of Rehabilitation Medicine, Capital Medical University, Beijing, China

* Author to whom correspondence should be addressed.

https://doi.org/10.54254/2753-8818/2024.17988

Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disease that primarily affects individuals in late adulthood and early adulthood. Its prevalence is rising annually, posing a significant challenge to global public health. While existing pharmacological agents can modestly retard the progression of the disease, they are unable to enhance the cognitive function of patients meaningfully. As an emerging intervention, brain-computer interface (BCI) technology offers a novel cognitive rehabilitation pathway for individuals with Alzheimer's disease. In light of the current state of research on Alzheimer's disease, this paper examines the underlying mechanisms of AD-related cognitive impairment and elucidates the fundamental principles and cognitive rehabilitation theories associated with the brain-computer interface. It highlights the potential applications of BCI in various aspects of Alzheimer's disease management, including diagnosis, monitoring, assessment, and personalized rehabilitation training. This discussion underscores the promise and value of BCI technology in addressing the cognitive challenges associated with Alzheimer's disease and provides insights into the future directions of BCI research in this field.

Keywords

Brain-computer Interface, Alzheimer's Disease, Cognitive Rehabilitation, Neuroplasticity

[1]. Li X, Feng X, Sun X, Hou N, Han F, Liu Y. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2019. Front Aging Neurosci. 2022 Oct 10;14:937486. doi: 10.3389/fnagi.2022.937486. PMID: 36299608; PMCID: PMC9588915.

[2]. Ji Z, Chen Q, Yang J, Hou J, Wu H, Zhang L. Global, regional, and national health inequalities of Alzheimer's disease and Parkinson's disease in 204 countries, 1990-2019. Int J Equity Health. 2024 Jun 19;23(1):125. doi: 10.1186/s12939-024-02212-5. PMID: 38898437; PMCID: PMC11188225.

[3]. Wang YQ, Jia RX, Liang JH, Li J, Qian S, Li JY, Xu Y. Dementia in China (2015-2050) estimated using the 1% population sampling survey in 2015. Geriatr Gerontol Int. 2019 Nov;19(11):1096-1100. doi: 10.1111/ggi.13778. Epub 2019 Sep 18. PMID: 31535462.

[4]. Christensen DD. Changing the course of Alzheimer's disease: anti-amyloid disease-modifying treatments on the horizon. Prim Care Companion J Clin Psychiatry. 2007;9(1):32-41. doi: 10.4088/pcc.v09n0106. PMID: 17599166; PMCID: PMC1894844.

[5]. Conti Filho CE, Loss LB, Marcolongo-Pereira C, Rossoni Junior JV, Barcelos RM, Chiarelli-Neto O, da Silva BS, Passamani Ambrosio R, Castro FCAQ, Teixeira SF, Mezzomo NJ. Advances in Alzheimer's disease's pharmacological treatment. Front Pharmacol. 2023 Jan 26;14:1101452. doi: 10.3389/fphar.2023.1101452. PMID: 36817126; PMCID: PMC9933512.

[6]. Delrieu J, Ousset PJ, Caillaud C, Vellas B. 'Clinical trials in Alzheimer's disease': immunotherapy approaches. J Neurochem. 2012 Jan;120 Suppl 1:186-193. doi: 10.1111/j.1471-4159.2011.07458.x. Epub 2011 Nov 28. Retraction in: J Neurochem. 2021 Aug;158(3):821. doi: 10.1111/jnc.15435. PMID: 21883222.

[7]. Fan L, Mao C, Hu X, Zhang S, Yang Z, Hu Z, Sun H, Fan Y, Dong Y, Yang J, Shi C, Xu Y. New Insights Into the Pathogenesis of Alzheimer's Disease. Front Neurol. 2020 Jan 10;10:1312. doi: 10.3389/fneur.2019.01312. PMID: 31998208; PMCID: PMC6965067.

[8]. Wu X, Metcalfe B, He S, Tan H, Zhang D. A Review of Motor Brain-Computer Interfaces Using Intracranial Electroencephalography Based on Surface Electrodes and Depth Electrodes. IEEE Trans Neural Syst Rehabil Eng. 2024;32:2408-2431. doi: 10.1109/TNSRE.2024.3421551. Epub 2024 Jul 4. PMID: 38949928.

[9]. Perez-Valero E, Lopez-Gordo MA, Morillas C, Pelayo F, Vaquero-Blasco MA. A Review of Automated Techniques for Assisting the Early Detection of Alzheimer's Disease with a Focus on EEG. J Alzheimers Dis. 2021;80(4):1363-1376. doi: 10.3233/JAD-201455. PMID: 33682717.

[10]. Tayebi H, Azadnajafabad S, Maroufi SF, Pour-Rashidi A, Khorasanizadeh M, Faramarzi S, Slavin KV. Applications of brain-computer interfaces in neurodegenerative diseases. Neurosurg Rev. 2023 May 31;46(1):131. doi: 10.1007/s10143-023-02038-9. PMID: 37256332.

[11]. Ríos AS, Oxenford S, Neudorfer C, Butenko K, Li N, Rajamani N, Boutet A, Elias GJB, Germann J, Loh A, Deeb W, Wang F, Setsompop K, Salvato B, Almeida LB, Foote KD, Amaral R, Rosenberg PB, Tang-Wai DF, Wolk DA, Burke AD, Salloway S, Sabbagh MN, Chakravarty MM, Smith GS, Lyketsos CG, Okun MS, Anderson WS, Mari Z, Ponce FA, Lozano AM, Horn A. Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease. Nat Commun. 2022 Dec 14;13(1):7707. doi: 10.1038/s41467-022-34510-3. PMID: 36517479; PMCID: PMC9751139.

Cite this article

Yang,W. (2024). Brain-computer interfaces in cognitive rehabilitation for Alzheimer's disease. Theoretical and Natural Science,64,163-169.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 4th International Conference on Biological Engineering and Medical Science

Conference website: https://2024.icbiomed.org/
ISBN:978-1-83558-731-7(Print) / 978-1-83558-732-4(Online)
Conference date: 25 October 2024
Editor:Alan Wang
Series: Theoretical and Natural Science
Volume number: Vol.64
ISSN:2753-8818(Print) / 2753-8826(Online)

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