Theoretical and Natural Science

Open access

Print ISSN: 2753-8818

Online ISSN: 2753-8826

About TNS

The proceedings series Theoretical and Natural Science (TNS) is an international peer-reviewed open access series which publishes conference proceedings from a wide variety of disciplinary perspectives concerning theoretical studies and natural science issues. TNS is published irregularly. The series publishes articles that are research-oriented and welcomes theoretical articles concerning micro and macro-scale phenomena. Proceedings that are suitable for publication in the TNS cover domains on various perspectives of mathematics, physics, chemistry, biology, agricultural science, and medical science. The series aims to provide a high-level platform where academic achievements of great importance can be disseminated and shared.

Aims & scope of TNS are:
·Mathematics and Applied Mathematics
·Theoretical Physics
·Chemical Science
·Biological Sciences
·Agricultural Science & Technology
·Basic Science of Medicine
·Clinical and Public Health

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Editors View full editorial board

Sheiladevi Sukumaran
SEGi University
Malaysia
Editorial Board
Roman Bauer
University of Surrey
United Kingdom
Editorial Board
Çiğdem Gülüzar Altıntop
Erciyes University
Turkey
Editorial Board
Florian Marcel Nuţă
Danubius University of Galaţi
Galaţi, Romania
Editor-in-Chief
floriann@univ-danubius.ro

Latest articles View all articles

Research Article
Published on 12 December 2024 DOI: 10.54254/2753-8818/2024.LA18246
Foyang Lyu

This paper presents the findings of every basis to know about an ACL (Anterior cruciate ligament) rupture. The purpose of this paper is to help understand aspects of an ACL rupture basis from its anatomy and physiology to recovery factors highlighting key aspects about the injury. Understanding anatomy of and around the knee can prevent further injuries to other ligaments or cartilage. Research indicates that ACL tears can be taken care of through various techniques surgical or non-surgical. Rates of ACL tears vary reliant on factors such as age, training type, gender and other factors. Diagnostics of ACL ruptures are very crucial to understand the type of treatment you need from manual tests such as the Lachman test or to decide for a CT, MRI, X-ray or an ultrasound. Rehabilitation programs are the most important part of the injury where the athlete should follow the guide of a physical therapist by a 3-5 month program.

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Lyu,F. (2024).Overview of Anterior Cruciate Ligament treatment.Theoretical and Natural Science,71,38-42.
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Research Article
Published on 12 December 2024 DOI: 10.54254/2753-8818/2024.LA18241
Yixin Wang

This paper conducts an in-depth analysis of the progression and current state of protein structure prediction methods, tracing the evolution from traditional techniques like homology modeling and threading to cutting-edge machine learning approaches such as AlphaFold and RoseTTAFold. A special focus is placed on recent developments like ESMFold, which significantly enhances computational efficiency. The review delves into the capabilities and limitations of these models, particularly in their handling of novel proteins and complex structures, and examines their implications for fields such as drug discovery and functional genomics. A comparative analysis across various methods highlights their operational frameworks, accuracy in prediction, and applicational relevance. This exploration not only provides a comprehensive overview of the state of the art but also offers insights into potential future directions for research and development in the domain of protein structure prediction, suggesting areas where further advancements are needed to improve prediction accuracy and expand the scope of applicability.

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Wang,Y. (2024).Advancements in Protein Structure Prediction: Novel Bioinformatics Algorithms and Applications.Theoretical and Natural Science,71,32-37.
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Research Article
Published on 12 December 2024 DOI: 10.54254/2753-8818/2024.LA18240
Yicong Gao

Chimeric antigen receptor T-cell (CAR-T) therapy, which first entered clinical use in 2010, it has achieved notable advancements in the treatment of blood cancers, leveraging the genetic modification of T cells to identify and destroy cancer cells. Some conditions like acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL), and multiple myeloma can be effective treated with this therapy, this is important because of the premise that various previous therapies have failed. The aim of this therapy is to make T cells express chimeric antigen receptors, a process that requires engineering them, enabling them to specifically recognize tumor antigens, such as CD19. Despite the promising outcomes, challenges remain, this is accompanied by side effects that are more distressing to patients, such as neurotoxicity, as well as limited efficacy in solid tumors. Recent research efforts are focused on optimizing CAR design, enhancing T cell Chimeric Antigen Receptor T-cell (CAR-T) therapy represents a groundbreaking advancement in the treatment of hematologic malignancies persistence, and expanding applicability to solid tumors. Developments of bispecific and allogeneic CAR-T cells, and combination therapies are being explored to mitigate current limitations. This review discusses the mechanism of action, clinical applications, and future directions of CAR-T cell therapy, emphasizing its transformative potential and the ongoing efforts to coping with the difficulties of the moment.

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Gao,Y. (2024).Current status and progress of research on CAR-T Cell Therapy for the treatment of hematological malignancies.Theoretical and Natural Science,71,26-31.
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Research Article
Published on 12 December 2024 DOI: 10.54254/2753-8818/2024.LA18237
Jiayi Huang

Circadian rhythm disruption has been increasingly recognized as a critical factor in the development and development of prostate cancer. Through a comprehensive examination of epidemiological evidence, molecular pathways, and experimental studies, circadian misalignment is shown to influence key biological processes that regulate hormone production, DNA repair, and immune function, all essential to maintaining cellular homeostasis. Disruptions in circadian rhythms can lead to altered gene expression, impacting pathways associated with tumour development. Epidemiological data reveal an elevated risk of prostate cancer in individuals with irregular circadian patterns, such as shift workers, further reinforcing the link between circadian dysregulation and cancer risk. Molecular studies have identified potential therapeutic targets within circadian- regulated pathways, offering new opportunities for intervention. Therapeutic approaches aimed at restoring circadian alignment may not only prevent prostate cancer but also improve treatment outcomes by enhancing the effectiveness of current therapies. Understanding the character of circadian rhythms in prostate cancer opens new avenues for prevention and treatment strategies that could ultimately improve patient prognosis. This paper delves into the strong link between circadian rhythm disruption and prostate cancer. Based on the comprehensive analysis of the basic concept of circadian rhythm, the characteristics of prostate cancer, and the epidemiological evidence, molecular mechanism, experimental studies and potential therapeutic targets associated with the two, it is concluded that circadian rhythm disorder plays a crucial role in the occurrence and development of prostate cancer, which provides a new perspective and direction for the prevention and treatment of prostate cancer.

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Huang,J. (2024).The Role of Circadian Rhythm Disruption in Prostate Cancer Development: Epidemiological, Molecular, and Therapeutic Perspectives.Theoretical and Natural Science,71,21-25.
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Volumes View all volumes

Volume 71December 2024

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Proceedings of ICBioMed 2024 Workshop: Computational Proteomics in Drug Discovery and Development from Medicinal Plants

Conference website: https://2024.icbiomed.org/

Conference date: 25 October 2024

ISBN: 978-1-83558-783-6(Print)/978-1-83558-784-3(Online)

Editor: Alan Wang, Ghulam Yaseen

Volume 70December 2024

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Proceedings of the 4th International Conference on Biological Engineering and Medical Science

Conference website: https://2024.icbiomed.org/

Conference date: 25 October 2024

ISBN: 978-1-83558-771-3(Print)/978-1-83558-772-0(Online)

Editor: Alan Wang

Volume 69December 2024

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Proceedings of the 3rd International Conference on Modern Medicine and Global Health

Conference website: https://2025.icmmgh.org/

Conference date: 1 January 0001

ISBN: 978-1-83558-769-0(Print)/978-1-83558-770-6(Online)

Editor: Sheiladevi Sukumaran

Volume 68December 2024

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Proceedings of the 3rd International Conference on Modern Medicine and Global Health

Conference website: https://2025.icmmgh.org/

Conference date: 1 January 0001

ISBN: 978-1-83558-767-6(Print)/978-1-83558-768-3(Online)

Editor: Sheiladevi Sukumaran

Indexing

The published articles will be submitted to following databases below: