Volume 131

Inflammatory bowel disease (IBD) is a global health concern. Existing therapies, including anti-inflammatory drugs and biologics, often suffer from limitations such as insufficient targeting and high cost. In this context, nanoformulations have shown significant potential due to their advantages in drug protection, targeted delivery, and multifunctional synergy. This article reviews the latest progress in the treatment of IBD with nanoparticles. It categorizes nanodelivery systems into two main types: drug delivery systems and plant-related delivery systems. The article also provides examples of each type, detailing their preparation methods, targeted delivery mechanisms, and experimental outcomes. The findings reveal that while studies have confirmed the effectiveness and advantages of nanoformulations for treating IBD, transformation encounters significant challenges. In the future, it is necessary to integrate new technologies to develop more intelligent nano-response systems and accelerate clinical verification, ultimately aiming for precision and universalization of IBD treatment.

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