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The Effect of Microglia on Depression
- 1 Shandong Experiment High School
* Author to whom correspondence should be addressed.
Abstract
This paper focuses on the relationship between microglia and depression. Depression is affected by multiple structures, cells, and hormones, including the hippocampus, amygdala, hypothalamic-pituitary-adrenal axis, gut microbiota, stem cells, and glucocorticoids. This paper explores the relationship between microglia and structures, how these structural changes lead to increased concentrations of microglia leading to depression, and current treatment options for depression. Treatment options include drug therapy, electroacupuncture, and stem cell therapy. All of these treatments significantly impact the cure of depression and, at the same time, affect the overactivated microglia cells. It is concluded that the production of depression is closely related to microglial cells.
Keywords
microglia, neuroscience, psychology, depression
[1]. Yirmiya R, Rimmerman N, Reshef R. Depression as a microglial disease. Trends Neurosci. 2015 Oct;38(10):637-658. doi: 10.1016/j.tins.2015.08.001. PMID: 26442697.
[2]. Zou Ju, Tan Sijie. The role of microglia in depression [J]. Journal of anatomy of the progress of science, 2017, 23 (5) : 541-544. The DOI: 10.16695 / j.carol carroll nki. 1006-2947.2017.05.026.
[3]. Cao P, Chen C, Liu A, Shan Q, Zhu X, Jia C, Peng X, Zhang M, Farzinpour Z, Zhou W, Wang H, Zhou JN, Song X, Wang L, Tao W, Zheng C, Zhang Y, Ding YQ, Jin Y, Xu L, Zhang Z. Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines. Neuron. 2021 Aug 18;109(16):2573-2589.e9. doi: 10.1016/j.neuron.2021.06.012. Epub 2021 Jul 6. PMID: 34233151.
[4]. Liao Yang, Che Huiqing. Microglia may promote depression by releasing exosomes [N]. Proceedings in China, 2021-12-24 (004). The DOI: 10.28514 / n.c. Nki NKXSB. 2021.004296.
[5]. Teng Wan, Xue Gao, Shunfeng Liu, Anna Meng, Hongying Lv, Zhuanzhu Wu, Shouhong Zhou. Microglia research progress of relationship between polarization and depression (English) [J]. Progress in biochemistry and biophysics, 2021, 13 (12) : 1404-1413. The DOI: 10.16476 / j. ibb. 2021.0199.
[6]. Teng Wan, Xue Gao, Shunfeng Liu, Anna Meng, Hongying Lv, Zhuanzhu Wu, Shouhong Zhou. Microglia research progress of relationship between polarization and depression (English) [J]. Progress in biochemistry and biophysics, 2021, 13 (12) : 1404-1413. The DOI: 10.16476 / j. ibb. 2021.0199.
[7]. Yan Ruisu, Liu Chuanxin. Research progress of microglia and the pathogenesis of depression [J]. Journal of jining medical college,2019,42(02):144-148.
[8]. Li Jiamei, Jiang Chunlei. The role of microglia in the pathogenesis of depression [J]. Journal of the second military medical university,2018,39(07):780-783.DOI:10.16781/j.0258-879x.2018.07.0780.
[9]. Wang Qiyang, Pan Mingmin, Yang Liping. The research progress of depression model of rat intestinal flora [J]. The chemistry of life, 2021 9 (8) : 1754-1762. DOI: 10.13488 / j.s MHX. 20200585.
[10]. Huang Wentao, Li Duoduo, Li Bing, Chen Heng, Li Wu. Effects of electroacupuncture on the activation and learning and memory ability of microglia cells in the subgranulosa region of the dentate gyrus in the hippocampus of depressed rats [J]. Chinese Journal of Experimental Animal Science, 2002,30(04):513-519.
[11]. Bai Fangfang, Wang Dou, Feng Weixing. The role of microglia in the pathogenesis of depression and the application of antidepressant drugs [J]. Journal of Shandong Medicine, 222,62(17):97-100.
[12]. Jiang Ruru, Li Xin, Ha Xiaoqin. The role of stem cells in treatment of depression [J]. Journal of China biological products, 2020 (12) : 1450-1453 + 1459. DOI: 10.13200 / j.carol carroll nki CJB. 003231.
Cite this article
Liu,X. (2023). The Effect of Microglia on Depression. Lecture Notes in Education Psychology and Public Media,8,31-36.
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Volume title: Proceedings of the International Conference on Social Psychology and Humanity Studies
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