Genomes, Transcriptomes, Proteomes, Metabolomes in Bioinformatics Investigating Alzheimer’s Disease

Research Article
Open access

Genomes, Transcriptomes, Proteomes, Metabolomes in Bioinformatics Investigating Alzheimer’s Disease

Conghan Li 1*
  • 1 fisheries college, Ocean university of China, Qingdao, China    
  • *corresponding author liconghan@stu.ouc.edu.cn
Published on 28 April 2023 | https://doi.org/10.54254/2753-8818/4/20220542
TNS Vol.4
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-915371-27-0
ISBN (Online): 978-1-915371-28-7

Abstract

Alzheimer’s disease is affecting many people, especially people older than 65, living in the world. However, the cause and cure of these disease continue to confuse the scientists. Omics analysis, which includes four levels: genomes, transcriptomes, proteomes and metabolomes analysis, can dig out the information lying behind large amount of data and it’s really useful for complex disease like AD (Alzheimer’s Disease). In this article, I talked about the four levels of omics analysis investigating AD in details. In each level, the general workflow, the information we can get and the examples in AD have been involved. This paper will give the readers a general view of the function of omics analysis in AD.

Keywords:

Genomes, metabolomes, transcriptomes, Alzheimer’s Disease, proteomes

Li,C. (2023). Genomes, Transcriptomes, Proteomes, Metabolomes in Bioinformatics Investigating Alzheimer’s Disease. Theoretical and Natural Science,4,175-181.
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References

[1]. Simon, R.P., M.J. Aminoff, and D.A. Greenberg, Clinical neurology. 2009: Lange Medical Books/McGraw-Hill.

[2]. Matthews, K.A., et al., Alzheimer's & Dementia. 15(1) 17-24 (2019).

[3]. Tan, M.S., et al., Computers in biology and medicine. 139 104947 (2021).

[4]. Vaz, M. and S. Silvestre, European Journal of Pharmacology. 887 173554 (2020).

[5]. Carrasquillo, M.M., et al., Journal of Alzheimer's Disease. 24(4) 751-758 (2011).

[6]. Uffelmann, E., et al., Nature Reviews Methods Primers. 1(1) 1-21 (2021).

[7]. Huang, X., et al., BMC neurology. 18(1) 1-8 (2018).

[8]. Park, C., J. Ha, and S. Park, Expert Systems with Applications. 140 112873 (2020).

[9]. Subramanian, A., et al., Proceedings of the National Academy of Sciences. 102(43) 15545-15550 (2005).

[10]. Mattick, J.S. and I.V. Makunin, Human molecular genetics. 15(suppl_1) R17-R29 (2006).

[11]. Zhang, B., et al., Cell. 153(3) 707-720 (2013).

[12]. Müller, M., et al., Neurobiology of aging. 35(1) 152-158 (2014).

[13]. Skillbäck, T., et al., Alzheimer's research & therapy. 5(5) 1-10 (2013).

[14]. Johnson, E.C., et al., Molecular neurodegeneration. 13(1) 1-22 (2018).

[15]. Villas-Boas, S.G., et al., Metabolome analysis: an introduction. 2007: John Wiley & Sons.

[16]. Fernie, A.R., Phytochemistry. 68(22-24) 2861-2880 (2007).

[17]. González-Domínguez, R., T. García-Barrera, and J.-L. Gómez-Ariza, Chemical Papers. 66(9) 829-835 (2012).

Cite this article

Li,C. (2023). Genomes, Transcriptomes, Proteomes, Metabolomes in Bioinformatics Investigating Alzheimer’s Disease. Theoretical and Natural Science,4,175-181.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 2nd International Conference on Biological Engineering and Medical Science (ICBioMed 2022), Part II

ISBN：978-1-915371-27-0(Print) / 978-1-915371-28-7(Online)
Editor：Gary Royle, Steven M. Lipkin
Conference website: http://www.icbiomed.org
Conference date: 7 November 2022
Series: Theoretical and Natural Science
Volume number: Vol.4
ISSN：2753-8818(Print) / 2753-8826(Online)

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References

[1]. Simon, R.P., M.J. Aminoff, and D.A. Greenberg, Clinical neurology. 2009: Lange Medical Books/McGraw-Hill.

[2]. Matthews, K.A., et al., Alzheimer's & Dementia. 15(1) 17-24 (2019).

[3]. Tan, M.S., et al., Computers in biology and medicine. 139 104947 (2021).

[4]. Vaz, M. and S. Silvestre, European Journal of Pharmacology. 887 173554 (2020).

[5]. Carrasquillo, M.M., et al., Journal of Alzheimer's Disease. 24(4) 751-758 (2011).

[6]. Uffelmann, E., et al., Nature Reviews Methods Primers. 1(1) 1-21 (2021).

[7]. Huang, X., et al., BMC neurology. 18(1) 1-8 (2018).

[8]. Park, C., J. Ha, and S. Park, Expert Systems with Applications. 140 112873 (2020).

[9]. Subramanian, A., et al., Proceedings of the National Academy of Sciences. 102(43) 15545-15550 (2005).

[10]. Mattick, J.S. and I.V. Makunin, Human molecular genetics. 15(suppl_1) R17-R29 (2006).

[11]. Zhang, B., et al., Cell. 153(3) 707-720 (2013).

[12]. Müller, M., et al., Neurobiology of aging. 35(1) 152-158 (2014).

[13]. Skillbäck, T., et al., Alzheimer's research & therapy. 5(5) 1-10 (2013).

[14]. Johnson, E.C., et al., Molecular neurodegeneration. 13(1) 1-22 (2018).

[15]. Villas-Boas, S.G., et al., Metabolome analysis: an introduction. 2007: John Wiley & Sons.

[16]. Fernie, A.R., Phytochemistry. 68(22-24) 2861-2880 (2007).

[17]. González-Domínguez, R., T. García-Barrera, and J.-L. Gómez-Ariza, Chemical Papers. 66(9) 829-835 (2012).

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