Effects of Polyunsaturated Fatty Acids on Human Health Through Intestinal Microbiota

Research Article
Open access

Effects of Polyunsaturated Fatty Acids on Human Health Through Intestinal Microbiota

Ruitong Zhang 1* , Zhuo Lyu 2
  • 1 International Education College, Zhengzhou University of Light Industry, Zhengzhou, 450000, China    
  • 2 International Curriculum Center, Beijing, 100080, China    
  • *corresponding author 1993022@zzuli.edu.cn
Published on 28 April 2023 | https://doi.org/10.54254/2753-8818/4/20220582
TNS Vol.4
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-915371-27-0
ISBN (Online): 978-1-915371-28-7

Abstract

Unsaturated fatty acids act a necessary part in the intestinal health of the host microbiota environment and immune ability by being transformed by intestinal microorganisms. Polyunsaturated fatty acids (PUFAs) are very important to the host body, also they influence many physiological activities of the body. The amount of polyunsaturated fatty acids synthesized by the human body cannot meet the daily needs of the human body, and it is necessary to obtain some essential fatty acids (EFA) from food. At the same time, some intestinal microorganisms can also synthesize and convert polyunsaturated fatty acids, which contribute to the regulation and control of host immunity. In addition, PUFAs are also beneficial to humans. They are critical in sustaining a healthy and stable gut microbiota environment and regulating and controlling host immunity. This paper summarized the conversion mechanism and effect of intestinal microbiota on polyunsaturated fatty acids, discussed whether polyunsaturated fatty acids can regulate human diseases and microbiota as health products, and determined the regulatory mechanism of polyunsaturated fatty acids.

Keywords:

unsaturated fatty acids, polyunsaturated fatty acids, gut microbiota

Zhang,R.;Lyu,Z. (2023). Effects of Polyunsaturated Fatty Acids on Human Health Through Intestinal Microbiota. Theoretical and Natural Science,4,331-337.
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References

[1]. J.M. , DE. Bauman, “American Oil Chemists’ Society Press, Champaign,” Advances in Conjugated Linoleic Acid Research, 180–199 (1999).

[2]. CE. Polan, JJ. McNeill, SB. Tove, “Biohydrogenation of unsaturated fatty acids by rumen bacteria,” J Bacteriol 88(4), 1056–1064 (1964).

[3]. C. Graham, C. Philip, “Conversion of α-linolenic acid to longer-chain polyunsaturated fatty acids in human adults,” INRA, EDP Sciences, 45(5), 581-597 (2005).

[4]. H. Sprecher, “The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids,” Prostagland- ins, Leukot Essent Fat Acids, 67 (2-3), 79–83 (2002).

[5]. J. Nicholas, S. David, “Polyunsaturated fatty acids in marine bacteria a dogma rewritten,” Microbiology, 62(6), 2429-2436 (1994).

[6]. Z. Zheng-san, G. Dong-sheng, J. Xiao-jun, et al. “Polyunsaturated Fatty Acids and Their Derivatives in the Intestinal Tract:a Review,” China Biotechnology, 38 (11), 66-75 (2018).

[7]. M. Helen, “Unsaturated fatty Acids,” Cambridge University Press, 581 (2), (2007).

[8]. M. Wijekoon, C. Parrish, A. Mansour, Reprint of "Effect of dietary substitution of fish oil with flaxseed or sunflower oil on muscle fatty acid composition in juvenile steelhead trout (_Oncorhynchus mykiss_) reared at varying temperatures," Aquaculture, 447, 108–115 (2015).

[9]. C. Quin, D. Vollman, S. Ghosh et al., “Fish oil supplemen- tation reduces maternal defensive inflammation and predicts a gut bacteriome with reduced immune priming capacity in infants,” The ISME Journal, 14 (8), 2090–2104 (2020).

[10]. W. Cao, C. Wang, Y. Chin et al., “DHA-phospholipids (DHA-PL) and EPA-phospholipids (EPA-PL) prevent intestinal dysfunction induced by chronic stress,” Food & Function, 10 (1), 277–288 (2019).

[11]. SC. Cunnane, SC. Williams, JD. Bell, et al., “Utilization of uniformly labeled 13C-polyunsaturated fatty acids in the synthesis of long-chain fatty acids and cholesterol accumulating in the neonatal rat brain,” J Neurochem, 62 (6), 2429–2436 (1994).

[12]. S. Serini, E. Fasano, E. Piccioni, “Differential Anti-Cancer Effects of Purified EPA and DHA and Possible Mechanisms Involved,” Current Medicinal Chemistry, 18(26), 4065-4075 (2011)

[13]. G. Piazzi, G. D’Argenio, A. Prossomariti, et al., “Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota,” Int. J. Cancer, 135 (9), 2004–2013 (2014).

[14]. K. Yang, H. Li, J. Dong, et al, “Expression profile of polyunsaturated fatty acids in colorectal cancer,” World J. Gastroenterol, 21, 2405–2412 (2015).

[15]. L. Caixie, J. Hong, Z. Jianlu, et al., “Effects of Dietary DHA/EPA Ratios on Fatty Acid Composition, Lipid Metabolism-related Enzyme Activity, and Gene Expression of Juvenile Grass Carp, Ctenopharyngodon idellus,” Journal of the World Aquaculture Society, 47(2), 287-296 (2016)

[16]. W. Xue-qing, M. Hui, H. Pin, “Research Progress of Nutrition and Biological Functions of PUFA,” Food Science, 25(11), 337-339 (2004)

[17]. L. Demaison, D. Moreau, “Dietary n-3 polyunsaturated fact acids and coronary heart disease-related mortality: a possible mechanism of action,” Cell Mol Life Sci, 59(3), 463-477 (2002)


Cite this article

Zhang,R.;Lyu,Z. (2023). Effects of Polyunsaturated Fatty Acids on Human Health Through Intestinal Microbiota. Theoretical and Natural Science,4,331-337.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 2nd International Conference on Biological Engineering and Medical Science (ICBioMed 2022), Part II

ISBN:978-1-915371-27-0(Print) / 978-1-915371-28-7(Online)
Editor:Gary Royle, Steven M. Lipkin
Conference website: http://www.icbiomed.org
Conference date: 7 November 2022
Series: Theoretical and Natural Science
Volume number: Vol.4
ISSN:2753-8818(Print) / 2753-8826(Online)

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References

[1]. J.M. , DE. Bauman, “American Oil Chemists’ Society Press, Champaign,” Advances in Conjugated Linoleic Acid Research, 180–199 (1999).

[2]. CE. Polan, JJ. McNeill, SB. Tove, “Biohydrogenation of unsaturated fatty acids by rumen bacteria,” J Bacteriol 88(4), 1056–1064 (1964).

[3]. C. Graham, C. Philip, “Conversion of α-linolenic acid to longer-chain polyunsaturated fatty acids in human adults,” INRA, EDP Sciences, 45(5), 581-597 (2005).

[4]. H. Sprecher, “The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids,” Prostagland- ins, Leukot Essent Fat Acids, 67 (2-3), 79–83 (2002).

[5]. J. Nicholas, S. David, “Polyunsaturated fatty acids in marine bacteria a dogma rewritten,” Microbiology, 62(6), 2429-2436 (1994).

[6]. Z. Zheng-san, G. Dong-sheng, J. Xiao-jun, et al. “Polyunsaturated Fatty Acids and Their Derivatives in the Intestinal Tract:a Review,” China Biotechnology, 38 (11), 66-75 (2018).

[7]. M. Helen, “Unsaturated fatty Acids,” Cambridge University Press, 581 (2), (2007).

[8]. M. Wijekoon, C. Parrish, A. Mansour, Reprint of "Effect of dietary substitution of fish oil with flaxseed or sunflower oil on muscle fatty acid composition in juvenile steelhead trout (_Oncorhynchus mykiss_) reared at varying temperatures," Aquaculture, 447, 108–115 (2015).

[9]. C. Quin, D. Vollman, S. Ghosh et al., “Fish oil supplemen- tation reduces maternal defensive inflammation and predicts a gut bacteriome with reduced immune priming capacity in infants,” The ISME Journal, 14 (8), 2090–2104 (2020).

[10]. W. Cao, C. Wang, Y. Chin et al., “DHA-phospholipids (DHA-PL) and EPA-phospholipids (EPA-PL) prevent intestinal dysfunction induced by chronic stress,” Food & Function, 10 (1), 277–288 (2019).

[11]. SC. Cunnane, SC. Williams, JD. Bell, et al., “Utilization of uniformly labeled 13C-polyunsaturated fatty acids in the synthesis of long-chain fatty acids and cholesterol accumulating in the neonatal rat brain,” J Neurochem, 62 (6), 2429–2436 (1994).

[12]. S. Serini, E. Fasano, E. Piccioni, “Differential Anti-Cancer Effects of Purified EPA and DHA and Possible Mechanisms Involved,” Current Medicinal Chemistry, 18(26), 4065-4075 (2011)

[13]. G. Piazzi, G. D’Argenio, A. Prossomariti, et al., “Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota,” Int. J. Cancer, 135 (9), 2004–2013 (2014).

[14]. K. Yang, H. Li, J. Dong, et al, “Expression profile of polyunsaturated fatty acids in colorectal cancer,” World J. Gastroenterol, 21, 2405–2412 (2015).

[15]. L. Caixie, J. Hong, Z. Jianlu, et al., “Effects of Dietary DHA/EPA Ratios on Fatty Acid Composition, Lipid Metabolism-related Enzyme Activity, and Gene Expression of Juvenile Grass Carp, Ctenopharyngodon idellus,” Journal of the World Aquaculture Society, 47(2), 287-296 (2016)

[16]. W. Xue-qing, M. Hui, H. Pin, “Research Progress of Nutrition and Biological Functions of PUFA,” Food Science, 25(11), 337-339 (2004)

[17]. L. Demaison, D. Moreau, “Dietary n-3 polyunsaturated fact acids and coronary heart disease-related mortality: a possible mechanism of action,” Cell Mol Life Sci, 59(3), 463-477 (2002)