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Treatment of Tetrodotoxin Poisoning
- 1 Shanghai High School International Division, 989 Baise Road, Shanghai, China
* Author to whom correspondence should be addressed.
Abstract
Tetrodotoxin (TTX), a natural toxin found in pufferfish and other organisms causes poisoning in many people who consume inadequately prepared fugu, a Japanese delicacy containing pufferfish. TTX functions as a voltage-gated sodium channel blocker and is highly toxic, with current treatment being only supportive. This review summarizes the current state of treatment of TTX poisoning, including current treatments and supportive care along with potential treatments from anti-TTX antibodies and vaccines tested in mice, but not yet in humans. Current treatment of TTX poisoning contains offering the patient respiratory support and treating the poisoning symptomatically. Multiple antibodies and antiserums against TTX have been developed and tested both in vitro and in vivo, and showed anti-TTX effect in mice, but not yet advanced to the stage of human testing.
Keywords
Tetrodotoxin, TTX, TTX poisoning, treatment
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Cite this article
Li,S.Y. (2023). Treatment of Tetrodotoxin Poisoning. Theoretical and Natural Science,4,370-376.
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Volume title: Proceedings of the 2nd International Conference on Biological Engineering and Medical Science (ICBioMed 2022), Part II
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