Potential regulatory mechanisms for NKCC1 and KCC2 that induce temporal lobe epilepsy

Zuowei Li

doi:10.54254/2753-8818/46/20240393

Research Article

Open access

Published on 31 July 2024

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Li,Z. (2024). Potential regulatory mechanisms for NKCC1 and KCC2 that induce temporal lobe epilepsy. Theoretical and Natural Science,46,65-71.

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Potential regulatory mechanisms for NKCC1 and KCC2 that induce temporal lobe epilepsy

Zuowei Li *^,1,

¹ The Webb Schools of California

* Author to whom correspondence should be addressed.

https://doi.org/10.54254/2753-8818/46/20240393

Abstract

The specific cause for mesial temporal lobe epilepsy at a molecular level has remained unknown for decades. Much research has proposed possible mechanisms that would induce mesial temporal lobe epilepsy. In this article, we briefly summarize some of the present theories on the cause of this disease and then introduce our theory on NKCC1 upregulation in hippocampal pyramidal cells as a potential cause of epilepsy. We specifically discussed the WNK pathway that regulates NKCC1 and KCC2 as a potential cause of epilepsy and explored another possible mechanism that overrides WNK and would potentially induce mesial temporal lobe epilepsy. Eventually, we discussed future expectations on medication according to our theory.

Keywords

NKCC1, KCC2, Temporal Lobe Epilepsy, WNK pathway, regulatory mechanism

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Cite this article

Li,Z. (2024). Potential regulatory mechanisms for NKCC1 and KCC2 that induce temporal lobe epilepsy. Theoretical and Natural Science,46,65-71.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 2nd International Conference on Modern Medicine and Global Health

Conference website: https://www.icmmgh.org/

ISBN：978-1-83558-569-6(Print) / 978-1-83558-570-2(Online)

Conference date: 5 January 2024

Editor：Mohammed JK Bashir

Series: Theoretical and Natural Science

Volume number: Vol.46

ISSN：2753-8818(Print) / 2753-8826(Online)

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