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Published on 31 July 2024
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Chen,Y. (2024). The overview of Clarithromycin treatment for Helicobacter pylori infection. Theoretical and Natural Science,46,142-148.
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The overview of Clarithromycin treatment for Helicobacter pylori infection

Yang Chen *,1,
  • 1 University of Iowa

* Author to whom correspondence should be addressed.

https://doi.org/10.54254/2753-8818/46/20240604

Abstract

Helicobacter pylori (H. pylori) is a Gram-negative bacillus that causes infections worldwide. Helicobacter pylori's drug resistance and infectivity are vital factors causing Helicobacter pylori infection. The virulence factors of Helicobacter pylori include acid escape virulence factors and epithelial cell colonizing factors, which can directly or indirectly cause chronic gastritis or gastric ulcer. As the resistance of Helicobacter pylori increases, a combination of multiple antibiotics is now the recommended therapy, and clarithromycin is one of them. The production process of clarithromycin and its effectiveness are essential points of discussion.

Keywords

Bacterial infection, Helicobacter pylori, Virulence factors, Clarithromycin

[1]. FitzGerald R, Smith SM. An Overview of Helicobacter pylori Infection. Methods Mol Biol. 2021;2283:1-14. doi: 10.1007/978-1-0716-1302-3_1. PMID: 33765303.

[2]. de Brito BB, da Silva FAF, Soares AS, Pereira VA, Santos MLC, Sampaio MM, Neves PHM, de Melo FF. Pathogenesis and clinical management of Helicobacter pylori gastric infection. World J Gastroenterol. 2019 Oct 7;25(37):5578-5589. doi: 10.3748/wjg.v25.i37.5578. PMID: 31602159; PMCID: PMC6785516.

[3]. Šterbenc A, Jarc E, Poljak M, Homan M. Helicobacter pylori virulence genes. World J Gastroenterol. 2019 Sep 7;25(33):4870-4884. doi: 10.3748/wjg.v25.i33.4870. PMID: 31543679; PMCID: PMC6737321.

[4]. Leung WK, Graham DY. Clarithromycin for Helicobacter pylori infection. Expert Opin Pharmacother. 2000 Mar;1(3):507-14. doi: 10.1517/14656566.1.3.507. PMID: 11249534.

[5]. Ansari S, Yamaoka Y. Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity. Toxins (Basel). 2019 Nov 19;11(11):677. doi: 10.3390/toxins11110677. PMID: 31752394; PMCID: PMC6891454.

[6]. Clarithromycin. New Drug Approvals. (2021, April 4). https://newdrugapprovals.org/2021/04/01/clarithromycin/

[7]. Leung WK, Graham DY. Clarithromycin for Helicobacter pylori infection. Expert Opin Pharmacother. 2000 Mar;1(3):507-14. doi: 10.1517/14656566.1.3.507. PMID: 11249534.

[8]. Marques AT, Vítor JMB, Santos A, Oleastro M, Vale FF. Trends in Helicobacter pylori resistance to clarithromycin: from phenotypic to genomic approaches. Microb Genom. 2020 Mar;6(3):e000344. doi: 10.1099/mgen.0.000344. PMID: 32118532; PMCID: PMC7200067.

Cite this article

Chen,Y. (2024). The overview of Clarithromycin treatment for Helicobacter pylori infection. Theoretical and Natural Science,46,142-148.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 2nd International Conference on Modern Medicine and Global Health

Conference website: https://www.icmmgh.org/
ISBN:978-1-83558-569-6(Print) / 978-1-83558-570-2(Online)
Conference date: 5 January 2024
Editor:Mohammed JK Bashir
Series: Theoretical and Natural Science
Volume number: Vol.46
ISSN:2753-8818(Print) / 2753-8826(Online)

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