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Published on 12 October 2024
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Li,Z. (2024).The Current Treatment for Neurodegenerative Diseases.Theoretical and Natural Science,54,82-87.
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The Current Treatment for Neurodegenerative Diseases

Zihao Li *,1,
  • 1 School of Life Science, Nanjing University, Nanjing, China.

* Author to whom correspondence should be addressed.

https://doi.org/10.54254/2753-8818/54/2024AU0130

Abstract

Neurodegenerative diseases (NDs) refer to dysfunction of central nerve system, characterized by progressive loss of neuronal structure and function, ultimately resulting in decline in patients’ memory, motor ability, language and intelligence. The typical NDs include age related diseases like Aleimer’s disease (AD) and genetic diseases such as Huntington’s diseases (HD) and amyotrophic lateral sclerosis (ALS). NDs impose heavy economic burden and suffer to the enormous patients over the world, however, many types of NDs do not have a cure; existing treatments only aim to improve their symptoms. Under that condition, Gene therapy has shown potential for transporting some genetic products into the cells and correct faulty genes. Over the years, research have highlighted the promise of gene therapies using AAV vector in treating NDs. At the same time, a number of emerging therapeutic technologies for neurodegenerative diseases, such as epigenetic interventions through acetylation/deacetylation, gene therapies that target specific mRNAs or non-coding RNAs, and photo biomodulation therapies that can act on brain tissue, are also being studied. In this discussion, we explore the historical, present, and future outlook of gene therapies for neurodegenerative conditions.

Keywords

Neurodegenerative disease, treatment, CAR-T, AAV

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Cite this article

Li,Z. (2024).The Current Treatment for Neurodegenerative Diseases.Theoretical and Natural Science,54,82-87.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of ICBioMed 2024 Workshop: Workshop on Intelligent Medical Data Analysis for Precision Medicine

Conference website: https://2024.icbiomed.org/
ISBN:978-1-83558-629-7(Print) / 978-1-83558-630-3(Online)
Conference date: 25 October 2024
Editor:Byeongsang Oh, Alan Wang
Series: Theoretical and Natural Science
Volume number: Vol.54
ISSN:2753-8818(Print) / 2753-8826(Online)

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