Download pdf
The mechanism of reversal of multidrug resistance in cancer by a Chinese medicine monomer named Zhebeimu
- 1 School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
* Author to whom correspondence should be addressed.
Abstract
Chemotherapy is one of the commonly used means of tumour treatment, but the occurrence of tumour multidrug resistance (MDR) has added great difficulties to tumour treatment and caused serious physical and psychological harm to patients. Modern pharmacological studies have shown that Zhebeimu (Fritillaria thunbergii Miq, ZBM) has the effect of reversing the drug resistance of tumour cells, and it is commonly used in the study of various malignant tumours, such as leukaemia, breast cancer and hepatocellular carcinoma. By analysing and summarizing the chemical constituents of ZBM and their related studies on reversal of tumour cell resistance in recent years, the article concludes that the chemical constituents in ZBM can achieve their reversal of drug resistance in a variety of tumour cells by inhibiting the expression of P-glycoprotein (P-gp), decreasing the exocytosis of drugs, increasing the concentration of intracellular drugs, modulating the ROS, and other mechanisms. At present, there is a relative lack of research and treatment of tumour MDR in clinical practice, and the search for reversal agents and reversal strategies for tumour MDR has become an urgent problem, and this paper provides an in-depth study of ZBM, which provides a reliable basis for subsequent application in clinical practice.
Keywords
Tumour, multidrug resistance, Zhebeimu, Chinese medicine monomer.
[1]. Sung, H Ferlay J Siegel R L et al 2021 Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J Clin 71 3 209-249
[2]. Liu Y Cao Y & Kuang R 2024 Research progress of mechanism of tumor multidrug resistance and reversal by traditional Chinese medicine Chin Pharm J 59 7 561-570
[3]. Zhu X An C Li Q et al 2017 Thunberg fritillary bulb's origin and development World Chin Med 12 01 211-216+221
[4]. Xiao F Li L Wang C et al 2023 Traditional Chinese herb for treating rheumatoid arthritis in clinic—Lessons learned from the target P-glycoprotein Lishizhen Med Mater Med Res 34 10 2475-2478
[5]. Zhang M Li C & Li G 2018 Recent progress in research on reversing the mechanism of tumor acquired drug resistance by traditional Chinese medicines Chin Pharm J 53 24 2069-2073
[6]. Debska S Owecka A Czernek U et al 2011 Transmembrane transporters ABCC: structure function and role in multidrug resistance of cancer cells Postepy Hig Med Dosw 65 552-561
[7]. Scheffer G L Wijngaard P L Flens M J Izquierdo M A Slovak M L Pinedo H M Meijer C J Clevers H C & Scheper R J 1995 The drug resistance-related protein LRP is the human major vault protein Nat Med 578-582
[8]. Pharmacopoeia of the People's Republic of China 2020 2020 Chinese Pharmacopoeia Commission China Med Sci Press
[9]. Sun Y & Liang W 2022 Research progress on chemical constituent pharmacological effects and clinical application of Fritillaria thunbergii Spec Wild Econ Anim Plant Res 44 01 87-92
[10]. Cui M C Zhang J Y Chen S J et al 2016 Identification of alkaloids and flavonoids in all parts of Fritillaria thunbergii using LC-LTQ-Orbitrap MSn Chin J Chin Mater Med 41 11 2124
[11]. Hou Y Jin C Wen C & Ding K 2024 Research progress on the mechanism of action and targeting of traditional Chinese medicine polysaccharides Mod Tradit Chin Med Mater Med World Sci Technol 1-20
[12]. Hu K Zheng H Qi J et al 1999 Reversal of multidrug resistance in leukaemia cells by zhebeimu alkaloids Chin J Haematol 12 33-34
[13]. Wang Y F Gu Z Y Nie Y Z et al 2014 Effect of peiminine on enhancing anti-tumor activity of adriamycin on multi-drug resistance of gastric cancer xenografts in nude mice and its mechanism Chin Tradit Herb Drugs 45 05 686-690
[14]. Gu Z Y Zhang P Nie Y Z et al 2012 Screening for five alkaloids as reversal agents against gastric cancer multiple drug resistance and study on their mechanism Chin Tradit Herb Drugs 43 06 1151-1156
[15]. Wu J Gan P Gan H et al 2022 Study on the effect of Banxia Xiexin Decoction medicated serum on increasing human gastric cancer resistant cell line SGC7901/ADR chemosensitivity J Zunyi Med Univ 45 06 719-726
[16]. Qi Y Liao B Xu C et al 2017 Effects of peimine on cell viability and apoptosis of multidrug resistant human leukemia cells Shandong Med J 57 26 17-20
[17]. Dong X & Bi M 2010 Research progress on regulation of P-glycoprotein by reactive oxygen species Chin Pharmacol Bull 26 10 1386-1390
[18]. Zhang T 2024 The mechanism of peimine inducing apoptosis of gastric cancer MKN-45 cells by regulating ROS mediated signaling pathways Heilongjiang Bayi Agricultural University
[19]. Chen Z Huang C Ma T et al 2018 Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells Phytomedicine 43 37-45
[20]. Wang H Tao L Qi K et al 2015 Quercetin reverses tamoxifen resistance in breast cancer cells J Buon 20 3 707-713
[21]. Li S Zhao Q Wang B et al 2018 Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation Phytother Res 32 8 1530-1536
Cite this article
Gu,R. (2024). The mechanism of reversal of multidrug resistance in cancer by a Chinese medicine monomer named Zhebeimu. Theoretical and Natural Science,62,52-57.
Data availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
Disclaimer/Publisher's Note
The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of EWA Publishing and/or the editor(s). EWA Publishing and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
About volume
Volume title: Proceedings of the 4th International Conference on Biological Engineering and Medical Science
© 2024 by the author(s). Licensee EWA Publishing, Oxford, UK. This article is an open access article distributed under the terms and
conditions of the Creative Commons Attribution (CC BY) license. Authors who
publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons
Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this
series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published
version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial
publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and
during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See
Open access policy for details).