Download pdf
Research Progress Regarding the Mechanism of Acupuncture in the Treatment of Stroke on the Nervous System
- 1 Department of Medicine, Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine, Nanning, Jiangsu, 530000, China
* Author to whom correspondence should be addressed.
Abstract
Stroke is one of the leading causes of disability and death worldwide. Acupuncture, as a traditional Chinese medicine, has received considerable attention recently for its use in stroke-related nervous system treatments. Acupuncture exerts therapeutic effects through multiple mechanisms, including stimulating and regulating related factors and signaling pathways to play anti-inflammatory, neuronal repair and protective effects; controlling glial cell polarization to promote self-repair after brain injury, etc. Acupuncture has been shown to markedly decrease the inflammatory response following a stroke, facilitate nerve regeneration and cell proliferation within the central nervous system, enhance cerebral blood flow in ischemic regions, diminish neuron apoptosis, and ultimately lead to improvements in neurological function and quality of life for stroke patients. Nevertheless, the precise neural mechanisms underlying acupuncture's effects on stroke remain incompletely elucidated, warranting further comprehensive investigation. This article reviews the research progress on the neural mechanisms of acupuncture in the treatment of stroke in recent years, with a view to providing scientific basis and reference for its clinical application.
Keywords
Acupuncture, Stroke, Nervous system, Neural mechanisms.
[1]. Timm L Kamwesiga J Kigozi S et al 2023 Struck by stroke - experiences of living with stroke in a rural area in Uganda BMC Public Health 23 1 1063
[2]. Su D Zhang R Wang X Ding Q Che F Zhang W Wu W Li P & Tang B 2024 A new multi-parameter imaging platform for in vivo drug efficacy evaluation of ischemic stroke Talanta 266 Pt 2 125133
[3]. Li L Zhu W Lin G et al 2022 Effects of acupuncture in ischemic stroke rehabilitation: A randomized controlled trial Front Neurol 13 897078
[4]. Qin S Zhang Z Zhao Y et al 2022 The impact of acupuncture on neuroplasticity after ischemic stroke: A literature review and perspectives Front Cell Neurosci 16 817732
[5]. Guo C Zhou X Wang X et al 2023 Annao Pingchong decoction alleviates neurological impairment by attenuating neuroinflammation and apoptosis in intracerebral hemorrhage rats J Ethnopharmacol 310 116298
[6]. Gimenez M Schickling B M Lopes L R & Miller F J Jr 2016 Nox1 in cardiovascular diseases: Regulation and pathophysiology Clin Sci Lond 130 3 151-165
[7]. Wang M Pan W Xu Y Zhang J Wan J & Jiang H 2022 Microglia-mediated neuroinflammation: A potential target for the treatment of cardiovascular diseases J Inflamm Res 15 3083-3094
[8]. Jurcau A & Simion A 2022 Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: From pathophysiology to therapeutic strategies Int J Mol Sci 23 1 14
[9]. Zhang Z Chen L Guo Y Li D et al 2023 The neuroprotective and neural circuit mechanisms of acupoint stimulation for cognitive impairment Chin Med 18 1 8
[10]. Madangarli N Bonsack F Dasari R & Sukumari-Ramesh S 2019 Intracerebral hemorrhage: Blood components and neurotoxicity Brain Sci 9 11 316
[11]. Hu X Bao Y Li M Zhang W & Chen C 2024 The role of ferroptosis and its mechanism in ischemic stroke Exp Neurol 372 114630
[12]. Zhang Y Lu X Tai B Li W & Li T 2021 Ferroptosis and its multifaceted roles in cerebral stroke Front Cell Neurosci 15 615372
[13]. Jia B Li J Song Y & Luo C 2023 ACSL4-mediated ferroptosis and its potential role in central nervous system diseases and injuries Int J Mol Sci 24 12 10021
[14]. Fu T C Wang G R Li Y X et al 2024 Mobilizing endogenous neuroprotection: The mechanism of the protective effect of acupuncture on the brain after stroke Front Neurosci 18 1181670
[15]. Chavez L M Huang S S MacDonald I et al 2017 Mechanisms of acupuncture therapy in ischemic stroke rehabilitation: A literature review of basic studies Int J Mol Sci 18 11 2270
[16]. Miao C Li X & Zhang Y 2023 Effect of acupuncture on BDNF signaling pathways in several nervous system diseases Front Neurol 14 1248348
[17]. Cheng C Y Lin J G Su S Y et al 2014 Electroacupuncture-like stimulation at Baihui and Dazhui acupoints exerts neuroprotective effects through activation of the brain-derived neurotrophic factor-mediated MEK1/2/ERK1/2/p90RSK/bad signaling pathway in mild transient focal cerebral ischemia in rats BMC Complement Altern Med 14 92
[18]. Wang M M Zhang M Feng Y S et al 2020 Electroacupuncture inhibits neuronal autophagy and apoptosis via the PI3K/AKT pathway following ischemic stroke Front Cell Neurosci 14 134
[19]. Wang Y F Chen W Y Lee C T et al 2022 Combinations of scalp acupuncture location for the treatment of post-stroke hemiparesis: A systematic review and Apriori algorithm-based association rule analysis Front Neurosci 16 956854
Cite this article
Xu,G. (2024). Research Progress Regarding the Mechanism of Acupuncture in the Treatment of Stroke on the Nervous System. Theoretical and Natural Science,62,58-63.
Data availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
Disclaimer/Publisher's Note
The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of EWA Publishing and/or the editor(s). EWA Publishing and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
About volume
Volume title: Proceedings of the 4th International Conference on Biological Engineering and Medical Science
© 2024 by the author(s). Licensee EWA Publishing, Oxford, UK. This article is an open access article distributed under the terms and
conditions of the Creative Commons Attribution (CC BY) license. Authors who
publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons
Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this
series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published
version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial
publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and
during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See
Open access policy for details).