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3D Bioprinting Innovations: Pioneering Solutions for Cardiac Disease
- 1 University of Toronto, Toronto, M5S 1A1, Canada
* Author to whom correspondence should be addressed.
Abstract
Cardiac disease persists as one of the leading causes of morbidity and mortality worldwide and therefore there is a critical need for the establishment of innovative treatment approaches. This review updates the innovations in 3D bioprinting technology and its applications in cardiac tissue engineering, a fast-developing field that aims to overcome the limitations of the current treatments of cardiac diseases. The 3D bioprinting technique enables the layer-by-layer construction of complex tissue structures emulating natural cardiac tissue in architecture and function using bio-inks composed of living cells, biocompatible materials, and growth factors. The paper reviews inkjet-based, extrusion, and laser-assisted bioprinting techniques, all having different advantages and challenges. It further identifies the need for proper biomaterials, namely natural and synthetic polymers, to facilitate cellular growth and differentiation, as well as the 4 main cell types utilized in the bioink. The 3D bioprinting applications will be reviewed in the fabrication of heart patches and prosthetic heart valves and their potential to improve cardiac repair and regeneration will be described. Although these developments are quite promising, challenges relating to scalability, cell viability, and regulatory considerations remain. The conclusion drawn is that further research in the refinement of bioprinting methodologies and integration with advanced technologies is required so that cardiac care can be revolutionized with personalized and effective therapeutic solutions.
Keywords
3D bioprinting technology, cardiac disease, innovations.
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Cite this article
Song,H. (2024). 3D Bioprinting Innovations: Pioneering Solutions for Cardiac Disease. Theoretical and Natural Science,63,45-50.
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Volume title: Proceedings of the 4th International Conference on Biological Engineering and Medical Science
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