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The Effects of Microbes on Human Personality: Anxiety and Depression
- 1 Beijing International Bilingual Academy-Tianjin Campus
* Author to whom correspondence should be addressed.
Abstract
The crucial involvement of the gut microbiota in sustaining human health and immune functionality is underscored by numerous studies, highlighting its pivotal role in mediating the intricate gut-brain axis. This underscores the capability of gut microbial inhabitants to modulate neurotransmission, dictate behavioral patterns, and exert further influences. Substantial evidence has converged on the association between gastrointestinal microbial compositions and conditions such as anxiety and depression, implying a regulatory interplay. This discussion examines data from preclinical in vivo studies and clinical literature, including investigations using germ-free animal models, as well as evaluations of therapeutic interventions involving prebiotics, probiotics, synbiotics, and postbiotics. Additionally, it explores the implications of fecal microbiota transplantation (FMT). By employing such diverse methodological approaches, a comprehensive understanding of the gut microbiome's contribution to neuropsychiatric well-being is emerging, underscoring the importance of gut-microbial balance for overall health.
Keywords
gut–brain axis, microbiota, anxiety, depression, probiotics
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Cite this article
Zhang,J. (2025). The Effects of Microbes on Human Personality: Anxiety and Depression. Theoretical and Natural Science,69,189-195.
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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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