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Unraveling the Genetic Basis of Bipolar Disorder: Implications for Future Research and Clinical Practice
- 1 The National University of Malaysia, UKM Bangi Selangor, 43600, Malaysia
* Author to whom correspondence should be addressed.
Abstract
This paper explores the genetic underpinnings of bipolar disorder (BD) to enhance understanding and inform clinical practice. It aims to examine the hereditary components of BD, identify specific genetic markers, and discuss their implications for diagnosis, treatment, and prevention. The study synthesizes findings from family and twin studies, molecular genetics research, genome-wide association studies (GWAS), and epigenetic analyses. It also reviews the role of genetic markers such as CACNA1C and ANK3 and their impact on neurobiological mechanisms associated with BD.The analysis confirms a strong genetic component in BD, with family and twin studies showing significant heritability. Specific genetic markers linked to neurotransmitter signaling and synaptic function are identified. The paper also discusses the role of voltage-gated calcium channels and synaptic function in BD pathophysiology, as well as the influence of epigenetic factors and gene-environment interactions.The findings underscore the importance of integrating genetic data into clinical practice for personalized treatment strategies. Future research should focus on rare genetic variants, deeper exploration of neurobiological mechanisms, and the challenges of translating genetic insights into clinical applications.
Keywords
Bipolar disorder, genetics, genome-wide association, epigenetics, personalized medicine
[1]. Smoller, J. W., & Finn, C. T. (2003). Family studies and the genetic epidemiology of bipolar disorder. Journal of Clinical Psychiatry, 64(2), 24-30.
[2]. Kieseppä, T., et al. (2004). The genetic epidemiology of bipolar disorder. Psychiatric Clinics of North America, 27(4), 533-551.
[3]. Ferreira, M. A. R., et al. (2008). Molecular genetics of bipolar disorder: insights from association studies. Journal of Affective Disorders, 104(1), 1-7.
[4]. Stahl, E. A., et al. (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature, 515(7526), 88-98.
[5]. Harrison, P. J., et al. (2018). Voltage-gated calcium channels and the pathophysiology of bipolar disorder. Frontiers in Neuroscience, 12, 758.
[6]. Rathje, S., et al. (2018). Genetic variation in SYNE1 affects synaptic function and mood regulation in bipolar disorder. Molecular Psychiatry, 23(7), 1475-1483.
[7]. Omar, S. H., et al. (2019). Differential gene expression in bipolar disorder: a large-scale analysis. Translational Psychiatry, 9(1), 172.
[8]. Duffy, A., et al. (2019). Epigenetic modification and neuroinflammation in bipolar disorder. Journal of Neuroimmunology, 327, 112-119.
[9]. Zhang, H., et al. (2020). Translational genomics and the future of personalized medicine in bipolar disorder. Psychiatry Research, 292, 113267.
[10]. O'Connell, K., & Coombes, P. (2021). Integrating genetic findings into clinical practice: the future of personalized medicine in bipolar disorder. American Journal of Psychiatry, 178(3), 241-248.
[11]. Dunn, E. C., et al. (2015). Stress, trauma, and epigenetic mechanisms in bipolar disorder. Biological Psychiatry, 78(4), 234-242.
[12]. McGowan, P. O., et al. (2009). Epigenetic regulation of the HPA axis and its relation to stress and mental health. Nature Neuroscience, 12(10), 1186-1192.
Cite this article
Long,A. (2025). Unraveling the Genetic Basis of Bipolar Disorder: Implications for Future Research and Clinical Practice. Theoretical and Natural Science,98,52-58.
Data availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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Volume title: Proceedings of the 3rd International Conference on Modern Medicine and Global Health
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