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The Molecular Mechanism of Hydrogen Sulfide Regulation on Nasopharyngeal Carcinoma Cell Growth
- 1 Beijing University of Chemical Technology, Nanjian Street, Beijing, China
* Author to whom correspondence should be addressed.
Abstract
Hydrogen sulfide (H₂S), as a critical gasotransmitter, plays a dual role in regulating tumor growth depending on its concentration and tumor type. In nasopharyngeal carcinoma (NPC), systematic reviews have demonstrated the involvement of H₂S in multiple cellular processes, including cell proliferation, apoptosis, and metastasis. This study systematically explores the molecular mechanisms of H₂S in NPC, focusing on its role in modulating signaling pathways, for example, PI3K/AKT, Wnt/β-catenin, and ROS-mediated pathways. The findings indicate that H₂S exerts its effects by regulating the expression of oncogenes and tumor suppressor genes, altering the tumor microenvironment, and influencing mitochondrial function. These insights provide a foundation for novel therapeutic strategies targeting H₂S metabolism in NPC.
Keywords
hydrogen sulfide, nasopharyngeal carcinoma, molecular mechanism, signal transduction, therapeutic target
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Cite this article
Hou,F. (2025). The Molecular Mechanism of Hydrogen Sulfide Regulation on Nasopharyngeal Carcinoma Cell Growth. Theoretical and Natural Science,102,1-8.
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