The Role of Gut Microbiota in the Development of Colorectal Cancer (CRC)

Weicheng  Zhang

doi:10.54254/2753-8818/2025.22053

Research Article

Open access

Published on 17 April 2025

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Zhang,W. (2025). The Role of Gut Microbiota in the Development of Colorectal Cancer (CRC). Theoretical and Natural Science,93,19-25.

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The Role of Gut Microbiota in the Development of Colorectal Cancer (CRC)

Weicheng Zhang *^,1,

¹ Shanghai Experimental Foreign Language School Puxi Campus, Shanghai, China

* Author to whom correspondence should be addressed.

https://doi.org/10.54254/2753-8818/2025.22053

Abstract

In recent years, CRC has gradually become one of the most common and deadliest types of cancer worldwide. Numerous studies in modern biology have explored the gut microbiota, revealing an inseparable relationship between microbial composition and CRC development. Currently, multiple articles suggest that microbial products can help promote or inhibit the formation of tumor microenvironment, while different dietary can help reshape the distribution of gut microbiota. This retrospective article aims to summarize previous experimental findings on how gut microbiota and dietary affect tumor progression through microbial products and propose possible future research directions as well. Short chain fatty acids and secondary bile acids mainly used to regulate the tumor microenvironment and has been widely studied. Additionally, research indicates that high protein and high dietary fiber diet with Omega-3 fatty acids contributes to the formation of SCFAs, thus reduced intestinal inflammatory response and reduces the risk of CRC induction.

Keywords

CRC, gut microbiota, microbial products, dietary

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Cite this article

Zhang,W. (2025). The Role of Gut Microbiota in the Development of Colorectal Cancer (CRC). Theoretical and Natural Science,93,19-25.

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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 3rd International Conference on Environmental Geoscience and Earth Ecology

Conference website: https://2025.icegee.org/

ISBN：978-1-83558-976-2(Print) / 978-1-83558-975-5(Online)

Conference date: 16 June 2025

Editor：Alan Wang

Series: Theoretical and Natural Science

Volume number: Vol.93

ISSN：2753-8818(Print) / 2753-8826(Online)

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