What’re the functions and characteristics of stem cell

Research Article
Open access

What’re the functions and characteristics of stem cell

Chengwen Chu 1*
  • 1 Southwest Jiaotong University    
  • *corresponding author 1156657506@qq.com
Published on 4 December 2023 | https://doi.org/10.54254/2753-8818/15/20240479
TNS Vol.15
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-83558-193-3
ISBN (Online): 978-1-83558-194-0

Abstract

This paper gives a prologue to the idea of stem cells, explaining their central attributes of self-recharging, multiplication, and separation. Stem cells assume a critical part in keeping up with tissue homeostasis and deal massive potential for different applications, including regenerative medication and tissue designing. The conversation includes pluripotent stem cells, embryonic stem cells, and the strategy of somatic cell nuclear transfer. Moral worries connected with stem cell research are additionally tended to. Stem cell research keeps on progressing quickly, with continuous clinical preliminaries showing the developing excitement to use stem cells for tending to neglected clinical requirements.

Keywords:

Self-Renew, Proliferation, Differentiation, Gene Expression

Chu,C. (2023). What’re the functions and characteristics of stem cell. Theoretical and Natural Science,15,197-200.
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1. Introduction

As of late, the expression "stem cell" has acquired commonality among the general public, yet numerous people actually miss the mark on extensive comprehension of these striking cells. To set out on our investigation, it is fundamental to characterize what stem cells are. Stem cells are a classification of cells which have two particular capacities: self-renewal and differentiation. These cells have the extraordinary capacity to both duplicate and change into cells with new characteristics and capabilities. Stem cells, in this manner, hold enormous commitment for different applications in the field of tissue designing. Be that as it may, in spite of significant headways in our insight, researchers keep on examining different features of stem cells, and we have not yet completely unwound their true capacity.

Accordingly, stem cells and the tissue-designed develops consolidating them are as of now going through thorough preclinical testing and clinical assessment in various exploration review, pointed toward outfitting their regenerative potential.

Stem cells assume a critical part in keeping up with the body's harmony, guaranteeing an exact harmony between cell misfortune and substitution. To outline, think about the consistent turnover of red platelets: millions die every day, yet an equivalent number are constantly delivered to renew them. Hematopoietic stem cells dwelling in the bone marrow are answerable for this amazing accomplishment, supplanting the whole red platelet populace around like clockwork. Essentially, the skin goes through continuous cell reestablishment, arranged by epithelial stem cells situated in the basal layers, which move to the surface as the peripheral cornified epithelial layer sheds [1], These models highlight the surprising capability of stem cells, which is creating new, sound cells depending on situation by the body. Notwithstanding, our understanding of the total degree of their regenerative capacities stays a subject of continuous examination.

In synopsis, stem cells are fundamental for keeping up with the body's balance by guaranteeing the proficient substitution of harmed or broken-down cells. In any case, the full extent of their regenerative likely keeps on being a subject of investigation and study.

2. Characteristics

Stem cells have a few key characteristics that put them aside from other cell types and characterize their exceptional properties. These characteristics are vital for understanding the assorted jobs stem cells can play in both ordinary physiology and clinical applications.

2.1. Self-Renewal

One of the characterizing elements of stem cells is their capacity for self-renewal. This special capacity permits a stem cell to gap and lead to indistinguishable duplicates of itself. Self-renewal keeps a steady populace of stem cells over the long haul, guaranteeing their accessibility all through the formative cycle and, at times, for the whole life expectancy of an organic entity.

2.2. Proliferation

Proliferation is one more basic element of stem cells. It alludes to the interaction by which a solitary stem cell can lead to a huge number of girl cells. This capacity is fundamental for the development and improvement of tissues and organ systems. The excursion from a treated egg to a completely useful grown-up creature depends on the stem cells’ ability of proliferation [2], prompting the progressive development of complicated tissues and organs.

2.3. Cell Specialization

One more main trait of stem cells is their exceptional capacity to go through separation [3], changing into more particular cell types, each with its own unmistakable capability and attributes. This course of separation includes the actuation and deactivation of explicit qualities, bringing about the outflow of new qualities, mRNA, and proteins. Separation can be set off by different elements, like changes in the cellular climate, modifications in supplement accessibility, or the presence or nonappearance of explicit flagging atoms.

2.4. Utilizing Antibody-Based Flow Cytometry

Concentrating on stem cells over the long run can be very difficult because of their extraordinary properties. One huge methodology for researching stem cells is through antibody-based flow cytometry. This technique gives a depiction of the proteins [1], communicated by stem cells, offering important experiences into the qualities effectively interpreted inside these cells. It demonstrates especially valuable for describing populaces of stem cells by analyzing their profiles of surface protein articulation.

2.5. Gene Expression Analysis

Notwithstanding flow cytometry, gene expression analysis is one more central strategy utilized in stem cell research. This technique supplements flow cytometry by giving an exhaustive perspective on the genetic changes that happen during stem cell proliferation and differentiation. Analysts can survey changes in gene expression, which are affected by factors like DNA compaction, methylation, demethylation, and the openness of record elements to genes. Gene expression analysis additionally reaches out to the assessment of non-coding RNAs, for example, administrative microRNAs, which assume fundamental parts in cellular guideline.

3. Properties

Stem cells show a scope of properties that make them extraordinary and flexible in different natural cycles and applications. These properties are essential for figuring out the assorted jobs and possibilities of various sorts of stem cells.

3.1. Ability to respond to their surroundings

Stem cells have a surprising skill to adjust and answer their microenvironment, a trademark urgent to their diverse jobs in both turn of events and tissue fix. This versatility can be compared to a meta-stable state, empowering stem cells to explore and conform to changing circumstances as they progress through different conditions overstretched periods. Critically, this versatility underlines their true capacity for tissue regeneration and fix, as stem cells can adjust their formative destiny affected by nearby factors and the length of openness to specific conditions. This responsiveness is especially clear in embryonic stem cells, which additionally show meta-stable states. Understanding the multifaceted exchange between stem cells and their environmental elements is fundamental for bridling their remedial potential and propelling our perception of their organic importance.

3.2. Pluripotent Stem Cells

Pluripotent stem cells address an unmistakable class of stem cells with striking capacities. These cells can be obtained from different starting points, like undeveloped organisms, microbe cell forerunners, or they can be misleadingly produced through hereditary control from other cell types. Pluripotent stem cells have a remarkable ability to separate into cells from every one of the three microbe layers: endoderm, mesoderm, and ectoderm [4]. This expansive separation potential implies that pluripotent stem cells can cause an extensive variety of cell types tracked down in the human body. Be that as it may, they can't separate into extraembryonic tissues like the placenta and umbilical line. One of the most notable instances of pluripotent stem cells is embryonic stem cells.

3.3. Embryonic Stem Cells

Embryonic stem cells comprise a particular subtype of pluripotent stem cells. These cells are regularly gotten from the internal cell mass (ICM) of a creating incipient organism at the stage of blastocyst. The blastocyst addresses a beginning phase of embryonic turn of events and comprises of different parts, including the external trophectoderm layer, the liquid filled blastocoel, and the ICM. Embryonic stem cells have the excellent capacity to separate into a huge swath of cell types, delivering them a significant device in research and regenerative medication. In any case, their usage is a subject of moral discussion and debate, as it frequently involves the obliteration of undeveloped organisms.

3.4. Somatic Cell Nuclear Transfer

Somatic cell nuclear transfer (SCNT) is a pivotal strategy that has huge ramifications in stem cell exploration and cloning. This strategy includes the reinventing of somatic cells (non-conceptive cells) into a state looking like embryonic stem cells. The interaction involves supplanting the core of an egg cell with the core of a somatic cell, and afterward embedding this recently made cell into a substitute mother for additional turn of events. This technique was broadly used to clone Cart the sheep, showing the way that the cytoplasm of an embryonic stem cell can return a somatic cell core into an embryonic state equipped for typical turn of events.

4. Conclusion

The field of stem cell research isn't just logically fascinating yet in addition subject to different discussions, discusses, and moral contemplations. These discussions include a great many points connected with stem cells and their applications.

In summary, stem cells address a promising road of exploration and clinical application in different fields, from regenerative medication to tissue designing. Their special properties, including self-renewal, proliferation, and differentiation, make them significant for understanding and possibly treating a wide cluster of ailments.

Nonetheless, discussions encompassing stem cells are not restricted to their logical potential. Moral worries have arisen, particularly on account of embryonic stem cells, which are gotten from human undeveloped organisms and can bring up issues about the start of life. Alternate points of view exist on when life starts, and these points of view impact perspectives toward the utilization of embryonic stem cells.

Regardless of these moral contemplations, research in stem cell science keeps on progressing quickly. Different kinds of stem cells, including pluripotent stem cells [5], and those generated through somatic cell nuclear transfer, offer new roads for logical disclosure and expected clinical applications. Clinical preliminaries using stem cells are progressing, exhibiting the developing excitement inside the logical and clinical networks to outfit the force of stem cells to address neglected clinical requirements.


References

[1]. Mark F. Pittenger, Candace Kerr, Chapter 2 - Stem Cells, Editor(s): Clemens A. Van Blitterswijk, Jan De Boer, Tissue Engineering (Second Edition), Academic Press, 2014. Pages 23-65, ISBN 9780124201453, https://doi.org/10.1016/B978-0-12-420145-3.00002-X.

[2]. Terzic A, Nelson TJ. Regenerative medicine primer. Mayo Clin Proc. 2013 Jul;88(7):766-75. doi: 10.1016/j.mayocp.2013.04.017. PMID: 23809322.

[3]. Mark F. Pittenger, Candace L. Kerr,Chapter 2 - Stem cells, Editor(s): Jan De Boer, Clemens A.Van Blitterswijk, Jorge Alfredo Uquillas, Nusrat Malik, Tissue Engineering (Third Edition), Academic Press, 2023, Pages 13-69, ISBN 9780128244593, https://doi.org/10.1016/B978-0-12-824459-3.00002-0. (https://www.sciencedirect.com/science/article/pii/B9780128244593 000020)

[4]. (2009). Index. In Emerging Technology Platforms for Stem Cells (eds U. Lakshmipathy, J.D. Chesnut and B. Thyagarajan). https://doi.org/10.1002/9780470454923.index

[5]. Wang Z, Lu H, Wang YC, Cong XQ. Human embryonic stem cells and liver diseases: from basic research to future clinical application. J Dig Dis. 2008 Feb;9(1):14-9. doi: 10.1111/j.1443-9573.2007.00319. x. PMID: 18251789.


Cite this article

Chu,C. (2023). What’re the functions and characteristics of stem cell. Theoretical and Natural Science,15,197-200.

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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 2nd International Conference on Modern Medicine and Global Health

ISBN:978-1-83558-193-3(Print) / 978-1-83558-194-0(Online)
Editor:Mohammed JK Bashir
Conference website: https://www.icmmgh.org/
Conference date: 5 January 2024
Series: Theoretical and Natural Science
Volume number: Vol.15
ISSN:2753-8818(Print) / 2753-8826(Online)

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References

[1]. Mark F. Pittenger, Candace Kerr, Chapter 2 - Stem Cells, Editor(s): Clemens A. Van Blitterswijk, Jan De Boer, Tissue Engineering (Second Edition), Academic Press, 2014. Pages 23-65, ISBN 9780124201453, https://doi.org/10.1016/B978-0-12-420145-3.00002-X.

[2]. Terzic A, Nelson TJ. Regenerative medicine primer. Mayo Clin Proc. 2013 Jul;88(7):766-75. doi: 10.1016/j.mayocp.2013.04.017. PMID: 23809322.

[3]. Mark F. Pittenger, Candace L. Kerr,Chapter 2 - Stem cells, Editor(s): Jan De Boer, Clemens A.Van Blitterswijk, Jorge Alfredo Uquillas, Nusrat Malik, Tissue Engineering (Third Edition), Academic Press, 2023, Pages 13-69, ISBN 9780128244593, https://doi.org/10.1016/B978-0-12-824459-3.00002-0. (https://www.sciencedirect.com/science/article/pii/B9780128244593 000020)

[4]. (2009). Index. In Emerging Technology Platforms for Stem Cells (eds U. Lakshmipathy, J.D. Chesnut and B. Thyagarajan). https://doi.org/10.1002/9780470454923.index

[5]. Wang Z, Lu H, Wang YC, Cong XQ. Human embryonic stem cells and liver diseases: from basic research to future clinical application. J Dig Dis. 2008 Feb;9(1):14-9. doi: 10.1111/j.1443-9573.2007.00319. x. PMID: 18251789.