The influence of immunology and anesthesia on cancer

Research Article
Open access

The influence of immunology and anesthesia on cancer

Suo Qin 1*
  • 1 Torrey Pines High School    
  • *corresponding author Qins1680@my.sduhsd.net
Published on 20 December 2023 | https://doi.org/10.54254/2753-8818/22/20230991
TNS Vol.22
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-83558-217-6
ISBN (Online): 978-1-83558-218-3

Abstract

Oncogenesis, characterized by abnormal cell proliferation, poses a global concern due to its high morbidity and mortality rates. Surgical interventions, often involving anesthetics, are common in cancer patients. Understanding their effects can lead to breakthroughs in cancer treatment, especially in the context of immunotherapy. Researchers have identified how the immune system and anesthetics affect the recurrence and metastasis of cancer. Immunotherapy, which utilizes the immune system to target tumors, has shown promise in clinical trials. In the adaptive immune system, T cells and B cells play significant roles in tumor detection and elimination. The immune system consists of innate and adaptive systems that help fight infections and diseases. Pattern recognition receptors (PRRs) trigger non-specific inflammatory responses in the innate immune system. Anesthesia is commonly administered to cancer patients, but different methods and groups of anesthesia exert divergent effects on oncological progression. Some studies have suggested a potential correlation between specific inhalation anesthetics and the modulation of tumor cell proliferation and apoptosis. Considering the interaction between the immune system and anesthetics, different combinations have the potential to either promote or inhibit cancer metastasis. Further exploration of these interactions is crucial for optimizing the administration of anesthesia in cancer patients and maximizing the efficacy of immunotherapy. This review sheds light on the complex interplay between immunotherapy, anesthesia, and cancer progression, providing valuable insights for future advancements in cancer treatment strategies.

Keywords:

immune system, immunotherapy, anesthesia, anesthetics, cancer

Qin,S. (2023). The influence of immunology and anesthesia on cancer. Theoretical and Natural Science,22,234-242.
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References

[1]. Cancer facts & figures 2022. American Cancer Society. (n.d.). https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2022.html

[2]. World Health Organization. (n.d.). Cancer. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/cancer

[3]. Roy, R., Singh, S. K., & Misra, S. (2022, December 27). Advancements in cancer immunotherapies. Vaccines. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861770/

[4]. Liu, C., Yang, M., Zhang, D., Chen, M., & Zhu, D. (2022, September 26). Clinical cancer immu-notherapy: Current progress and prospects. Frontiers. https://www.frontiersin.org/articles/10.3389/fimmu.2022.961805/full

[5]. Yang, L., Ning, Q., & Tang, S. (2022, March 18). Recent advances and next breakthrough in immunotherapy for cancer treatment. Journal of Immunology Research. https://www.hindawi.com/journals/jir/2022/8052212/

[6]. Liu, X., & Wang, Q. (2022, February 7). Application of anesthetics in cancer patients: Reviewin-g current existing link with tumor recurrence. Frontiers. https://www.frontiersin.org/articles/10.3389/fonc.2022.759057/full

[7]. Zhang, Y., & Pan, R. (2022, September 21). Effect of inhalation anesthetics on tumor metastasis. https://journals.sagepub.com/doi/10.1177/15330338221121092

[8]. Luan, T., Li, Y., Sun, L., Xu, S., Wang, H., Wang, J., & Li, C. (2022, July 6). Systemic immune effects of anesthetics and their intracellular targets in tumors. Frontiers. https://www.frontiersin.org/articles/10.3389/fmed.2022.810189/full

[9]. Bezu, L., Kepp, O., & Kroemer, G. (2022, August 1). Impact of local anesthetics on epigenetics in cancer. Frontiers. https://www.frontiersin.org/articles/10.3389/fonc.2022.849895/full

[10]. Brogi, E., & Forfori, F. (2022, July 20). Anesthesia and cancer recurrence: An overview – journ-al of anesthesia, analgesia and critical care. BioMed Central. https://janesthanalgcritcare.biomedcentral.com/articles/10.1186/s44158-022-00060-9

[11]. A, J., & M, H. (n.d.). General anesthetics on immune system cytokines: A narrative review article. Anesthesiology and pain medicine. https://pubmed.ncbi.nlm.nih.gov/33134146/

[12]. Dang, Y., Shi, X., Xu, W., & Zuo, M. (2018a, April 1). The effect of anesthesia on the immune system in colorectal cancer patients. Canadian journal of gastroenterology & hepatology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899868/#:~:text=Most%20inhaled%20anesthetics%2C%20opioids%2C%20local,increased%20recurrence%20of%20malignant%20tumors.

[13]. Vrbanović Mijatović V;Gatin L;Tonković D;Bandić Pavlović D;Smuđ Orehovec S;Miklić Bublić M;Mijatović D; (n.d.). The effect of regional vs. general anesthesia on the immune response in breast cancer surgery: A narrative review of the literature. Acta clinica Croatica. https://pubmed.ncbi.nlm.nih.gov/36824636/

Cite this article

Qin,S. (2023). The influence of immunology and anesthesia on cancer. Theoretical and Natural Science,22,234-242.

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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 3rd International Conference on Biological Engineering and Medical Science

ISBN：978-1-83558-217-6(Print) / 978-1-83558-218-3(Online)
Editor：Alan Wang
Conference website: https://www.icbiomed.org/
Conference date: 2 September 2023
Series: Theoretical and Natural Science
Volume number: Vol.22
ISSN：2753-8818(Print) / 2753-8826(Online)

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References

[1]. Cancer facts & figures 2022. American Cancer Society. (n.d.). https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2022.html

[2]. World Health Organization. (n.d.). Cancer. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/cancer

[3]. Roy, R., Singh, S. K., & Misra, S. (2022, December 27). Advancements in cancer immunotherapies. Vaccines. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861770/

[4]. Liu, C., Yang, M., Zhang, D., Chen, M., & Zhu, D. (2022, September 26). Clinical cancer immu-notherapy: Current progress and prospects. Frontiers. https://www.frontiersin.org/articles/10.3389/fimmu.2022.961805/full

[5]. Yang, L., Ning, Q., & Tang, S. (2022, March 18). Recent advances and next breakthrough in immunotherapy for cancer treatment. Journal of Immunology Research. https://www.hindawi.com/journals/jir/2022/8052212/

[6]. Liu, X., & Wang, Q. (2022, February 7). Application of anesthetics in cancer patients: Reviewin-g current existing link with tumor recurrence. Frontiers. https://www.frontiersin.org/articles/10.3389/fonc.2022.759057/full

[7]. Zhang, Y., & Pan, R. (2022, September 21). Effect of inhalation anesthetics on tumor metastasis. https://journals.sagepub.com/doi/10.1177/15330338221121092

[8]. Luan, T., Li, Y., Sun, L., Xu, S., Wang, H., Wang, J., & Li, C. (2022, July 6). Systemic immune effects of anesthetics and their intracellular targets in tumors. Frontiers. https://www.frontiersin.org/articles/10.3389/fmed.2022.810189/full

[9]. Bezu, L., Kepp, O., & Kroemer, G. (2022, August 1). Impact of local anesthetics on epigenetics in cancer. Frontiers. https://www.frontiersin.org/articles/10.3389/fonc.2022.849895/full

[10]. Brogi, E., & Forfori, F. (2022, July 20). Anesthesia and cancer recurrence: An overview – journ-al of anesthesia, analgesia and critical care. BioMed Central. https://janesthanalgcritcare.biomedcentral.com/articles/10.1186/s44158-022-00060-9

[11]. A, J., & M, H. (n.d.). General anesthetics on immune system cytokines: A narrative review article. Anesthesiology and pain medicine. https://pubmed.ncbi.nlm.nih.gov/33134146/

[12]. Dang, Y., Shi, X., Xu, W., & Zuo, M. (2018a, April 1). The effect of anesthesia on the immune system in colorectal cancer patients. Canadian journal of gastroenterology & hepatology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899868/#:~:text=Most%20inhaled%20anesthetics%2C%20opioids%2C%20local,increased%20recurrence%20of%20malignant%20tumors.

[13]. Vrbanović Mijatović V;Gatin L;Tonković D;Bandić Pavlović D;Smuđ Orehovec S;Miklić Bublić M;Mijatović D; (n.d.). The effect of regional vs. general anesthesia on the immune response in breast cancer surgery: A narrative review of the literature. Acta clinica Croatica. https://pubmed.ncbi.nlm.nih.gov/36824636/

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