Leucine rich-repeat sequence and the related protein in glioma

Yifeng Dai; Yun Di; Zhixuan Liu; Yajing Huang

doi:10.54254/2753-8818/23/20231052

Research Article

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Published on 20 December 2023

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Dai,Y.;Di,Y.;Liu,Z.;Huang,Y. (2023). Leucine rich-repeat sequence and the related protein in glioma. Theoretical and Natural Science,23,193-199.

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Leucine rich-repeat sequence and the related protein in glioma

Yifeng Dai *^,1, Yun Di ², Zhixuan Liu ³, Yajing Huang ⁴

¹ Nanchang University
² Wannan Medical College
³ Zhengzhou University
⁴ Guangdong Pharmaceutical University

* Author to whom correspondence should be addressed.

https://doi.org/10.54254/2753-8818/23/20231052

Abstract

Leucine rich-repeat sequence (LRR sequence) is a special class of polypeptide sequences composed of several adjacent leucine residues. LRR sequence participates in evolution between species and across species. This sequence is widespread in a variety of proteins and has important biological functions. LRR protein plays a major part in the development of the nervous system and the maintenance of normal function. In addition, a large number of leucine repeats are closely related to the occurrence of a variety of diseases, such as leucine-rich repeat disease, leucine-rich peptide aggregate. Most importantly, it correlates with the development of brain tumors like glioma. This article is primarily focused on the structure and function of LRR sequence and the associated LRR proteins. Moreover, we summary the LRR-contain transmembrane proteins in nerve system and highlight the function of these proteins in glioma progression which takes the sequencing of LRR a potential personalized diagnosis and treatment of brain tumors.

Keywords

leucine rich-repeat sequence, glioma, LRR transmembrane proteins

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Cite this article

Dai,Y.;Di,Y.;Liu,Z.;Huang,Y. (2023). Leucine rich-repeat sequence and the related protein in glioma. Theoretical and Natural Science,23,193-199.

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About volume

Volume title: Proceedings of the 3rd International Conference on Biological Engineering and Medical Science

Conference website: https://www.icbiomed.org/

ISBN：978-1-83558-219-0(Print) / 978-1-83558-220-6(Online)

Conference date: 2 September 2023

Editor：Alan Wang

Series: Theoretical and Natural Science

Volume number: Vol.23

ISSN：2753-8818(Print) / 2753-8826(Online)

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