Research progress of colloidal gold technology

Research Article
Open access

Research progress of colloidal gold technology

Zijia Zhong 1*
  • 1 Xiamen University    
  • *corresponding author 21620202204341@stu.xmu.edu.cn
Published on 20 December 2023 | https://doi.org/10.54254/2753-8818/23/20231061
TNS Vol.23
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-83558-219-0
ISBN (Online): 978-1-83558-220-6

Abstract

The colloidal gold technique is a technique that combines antigen-antibody immune reaction with colloidal gold labeling for antigen and antibody detection. This paper introduces the background, principle, application, advantages and disadvantages of this technique. The colloidal gold technique uses colloidal gold particles as markers to bind with antigens or antibodies and show red bands on the test strip. It has three methods: the double antibody sandwich method, competition method and indirect method. It can be used for things like environmental monitoring, food safety, and clinical diagnostics. It has the advantages of rapid, simple, low cost, and good stability, but also has the disadvantages of low sensitivity, poor specificity, difficult quantification, etc. In this paper, the background, principle, preparation method, application, advantages and disadvantages of colloidal gold are reviewed to provide readers with a comprehensive and systematic understanding. Although colloidal gold technology has made many achievements, there are still some challenges and difficulties in realizing the industrial application of colloidal gold, such as how to improve the stability, sensitivity, specificity and repeatability of colloidal gold.

Keywords:

colloidal gold, preparation method, application

Zhong,Z. (2023). Research progress of colloidal gold technology. Theoretical and Natural Science,23,204-209.
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References

[1]. Andalibi, M. R., Wokaun, A., Bowen, P. and Testino, A., “Kinetics and mechanism of metal nanoparticle growth via optical extinction spectroscopy and computational modeling: The curious case of colloidal gold,” ACS Nano 13(10), 11510-11521 (2019).

[2]. Patil, T., Gambhir, R., Vibhute, A. and Tiwari, A. P., “Gold Nanoparticles: Synthesis Methods, Functionalization and Biological Applications,” Journal of Cluster Science 34(2), 705-725 (2023).

[3]. Oliver, C., [Preparation of Colloidal Gold], Methods in Molecular Biology, Humana Press, New York & Boston, 363-367 (2010).

[4]. Yamaguchi, K. and Asakawa, H., “Preparation of colloidal gold for staining proteins electrotransferred onto nitrocellulose membranes,” Analytical Biochemistry 172(1), 104-107 (1988).

[5]. Shah, M., Badwaik, V., Kherde, Y., et al., “Gold nanoparticles: various methods of synthesis and antibacterial applications,” Frontiers in Bioscience (Landmark edition) 19(8), 1320-1344 (2014).

[6]. Zhang, Y., Abidi, W. and Berlin, J. M., “Colloidal Capsules Assembled from Gold Nanoparticles Using Small-Molecule Hydrophobic Cross-linkers,” Langmuir : the ACS journal of surfaces and colloids 35(52), 17037-17045 (2019).

[7]. Li, G., Wang, A., Chen, Y., et al., “Development of a colloidal gold-based immunochromatographic strip for rapid detection of severe acute respiratory syndrome coronavirus 2 spike protein,” Front Immunol. 12:635677 (2021).

[8]. Huang, C., Wen, T., Shi, F. J., et al., “Rapid Detection of IgM Antibodies against the SARS-CoV-2 Virus via Colloidal Gold Nanoparticle-Based Lateral-Flow Assay,” ACS Omega 5(21), 12550-12556 (2020).

[9]. Wang, D., Zhang, Z., Li, P., et al., “Time-Resolved Fluorescent Immunochromatography of Aflatoxin B1 in Soybean Sauce: A Rapid and Sensitive Quantitative Analysis,” Sensors (Basel, Switzerland) 16(7), E1094 (2016).

[10]. Wu, Y., Wu, M., Liu, C., et al., “Colloidal gold immunochromatographic test strips for broad-spectrum detection of Salmonella,” Food Control 126:108052 (2021).

[11]. Jennings, T. and Strouse, G., [Past, Present, and Future of Gold Nanoparticles], Nanoparticles: From Theory to Application, Wiley-VCH, Weinheim & Berlin, 81-120 (2004).

[12]. Saha, K., Agasti, S.S., Kim, C., t al., “Gold nanoparticles in chemical and biological sensing,” Chem. Rev. 112(5), 2739-2779 (2012).

[13]. Liu, Y. and Lu, Y., “Biosensing based on nanomaterials: a review,” Nanoscale Res. Lett. 14:100 (2019).

Cite this article

Zhong,Z. (2023). Research progress of colloidal gold technology. Theoretical and Natural Science,23,204-209.

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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 3rd International Conference on Biological Engineering and Medical Science

ISBN：978-1-83558-219-0(Print) / 978-1-83558-220-6(Online)
Editor：Alan Wang
Conference website: https://www.icbiomed.org/
Conference date: 2 September 2023
Series: Theoretical and Natural Science
Volume number: Vol.23
ISSN：2753-8818(Print) / 2753-8826(Online)

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References

[1]. Andalibi, M. R., Wokaun, A., Bowen, P. and Testino, A., “Kinetics and mechanism of metal nanoparticle growth via optical extinction spectroscopy and computational modeling: The curious case of colloidal gold,” ACS Nano 13(10), 11510-11521 (2019).

[2]. Patil, T., Gambhir, R., Vibhute, A. and Tiwari, A. P., “Gold Nanoparticles: Synthesis Methods, Functionalization and Biological Applications,” Journal of Cluster Science 34(2), 705-725 (2023).

[3]. Oliver, C., [Preparation of Colloidal Gold], Methods in Molecular Biology, Humana Press, New York & Boston, 363-367 (2010).

[4]. Yamaguchi, K. and Asakawa, H., “Preparation of colloidal gold for staining proteins electrotransferred onto nitrocellulose membranes,” Analytical Biochemistry 172(1), 104-107 (1988).

[5]. Shah, M., Badwaik, V., Kherde, Y., et al., “Gold nanoparticles: various methods of synthesis and antibacterial applications,” Frontiers in Bioscience (Landmark edition) 19(8), 1320-1344 (2014).

[6]. Zhang, Y., Abidi, W. and Berlin, J. M., “Colloidal Capsules Assembled from Gold Nanoparticles Using Small-Molecule Hydrophobic Cross-linkers,” Langmuir : the ACS journal of surfaces and colloids 35(52), 17037-17045 (2019).

[7]. Li, G., Wang, A., Chen, Y., et al., “Development of a colloidal gold-based immunochromatographic strip for rapid detection of severe acute respiratory syndrome coronavirus 2 spike protein,” Front Immunol. 12:635677 (2021).

[8]. Huang, C., Wen, T., Shi, F. J., et al., “Rapid Detection of IgM Antibodies against the SARS-CoV-2 Virus via Colloidal Gold Nanoparticle-Based Lateral-Flow Assay,” ACS Omega 5(21), 12550-12556 (2020).

[9]. Wang, D., Zhang, Z., Li, P., et al., “Time-Resolved Fluorescent Immunochromatography of Aflatoxin B1 in Soybean Sauce: A Rapid and Sensitive Quantitative Analysis,” Sensors (Basel, Switzerland) 16(7), E1094 (2016).

[10]. Wu, Y., Wu, M., Liu, C., et al., “Colloidal gold immunochromatographic test strips for broad-spectrum detection of Salmonella,” Food Control 126:108052 (2021).

[11]. Jennings, T. and Strouse, G., [Past, Present, and Future of Gold Nanoparticles], Nanoparticles: From Theory to Application, Wiley-VCH, Weinheim & Berlin, 81-120 (2004).

[12]. Saha, K., Agasti, S.S., Kim, C., t al., “Gold nanoparticles in chemical and biological sensing,” Chem. Rev. 112(5), 2739-2779 (2012).

[13]. Liu, Y. and Lu, Y., “Biosensing based on nanomaterials: a review,” Nanoscale Res. Lett. 14:100 (2019).

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