References
[1]. H. Na, Q. M, S. C, S. M, and P. Rl, (2019) “Cracking the Betel Nut: Cholinergic Activity of Areca Alkaloids and Related Compounds,” Nicotine Tob. Res. Off. J. Soc. Res. Nicotine Tob., vol. 21, no. 6, doi: 10.1093/ntr/ntx187.
[2]. Q. Lan, P. Guan, C. Huang, S. Huang, P. Zhou, and C. Zhang. (2022) “Arecoline Induces an Excitatory Response in Ventral Tegmental Area Dopaminergic Neurons in Anesthetized Rats,” Front. Pharmacol., vol. 13, p. 872212, doi: 10.3389/fphar.2022.872212.
[3]. X. Chen, Y. He, and Y. Deng. (2021) “Chemical Composition, Pharmacological, and Toxicological Effects of Betel Nut,” Evid.-Based Complement. Altern. Med. ECAM, vol. 2021, p. 1808081, doi: 10.1155/2021/1808081.
[4]. Y. Yang, H. Huang, Z. Cui, J. Chu, and G. Du. (2021) “UPLC-MS/MS and Network Pharmacology-Based Analysis of Bioactive Anti-Depression Compounds in Betel Nut,” Drug Des. Devel. Ther., vol. 15, pp. 4827–4836, doi: 10.2147/DDDT.S335312.
[5]. “SwissSimilarity: A Web Tool for Low to Ultra High Throughput Ligand-Based Virtual Screening | Journal of Chemical Information and Modeling.” https://pubs.acs.org/doi/full/10.1021/acs.jcim.6b00174.
[6]. M. Jing et al., (2018) “A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies,” Nat. Biotechnol., vol. 36, no. 8, pp. 726–737, doi: 10.1038/nbt.4184.
[7]. “AmplexTM Acetylcholine/Acetlycholinesterase Assay Kit.” https://www.thermofisher.cn/order/catalog/product/cn/zh/A12217.
[8]. E. L. Rodriguez et al., (2020) “Affinity Chromatography: A Review of Trends and Developments over the Past 50 Years,” J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci., vol. 1157, p. 122332, doi: 10.1016/j.jchromb.2020.122332.
Cite this article
Zhou,D. (2023). Guvacoline in betel nuts directly binds to and inhibits AChE activity, lowering ACh levels released by neurons. Theoretical and Natural Science,24,59-64.
Data availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
Disclaimer/Publisher's Note
The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of EWA Publishing and/or the editor(s). EWA Publishing and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
About volume
Volume title: Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
© 2024 by the author(s). Licensee EWA Publishing, Oxford, UK. This article is an open access article distributed under the terms and
conditions of the Creative Commons Attribution (CC BY) license. Authors who
publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons
Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this
series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published
version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial
publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and
during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See
Open access policy for details).
References
[1]. H. Na, Q. M, S. C, S. M, and P. Rl, (2019) “Cracking the Betel Nut: Cholinergic Activity of Areca Alkaloids and Related Compounds,” Nicotine Tob. Res. Off. J. Soc. Res. Nicotine Tob., vol. 21, no. 6, doi: 10.1093/ntr/ntx187.
[2]. Q. Lan, P. Guan, C. Huang, S. Huang, P. Zhou, and C. Zhang. (2022) “Arecoline Induces an Excitatory Response in Ventral Tegmental Area Dopaminergic Neurons in Anesthetized Rats,” Front. Pharmacol., vol. 13, p. 872212, doi: 10.3389/fphar.2022.872212.
[3]. X. Chen, Y. He, and Y. Deng. (2021) “Chemical Composition, Pharmacological, and Toxicological Effects of Betel Nut,” Evid.-Based Complement. Altern. Med. ECAM, vol. 2021, p. 1808081, doi: 10.1155/2021/1808081.
[4]. Y. Yang, H. Huang, Z. Cui, J. Chu, and G. Du. (2021) “UPLC-MS/MS and Network Pharmacology-Based Analysis of Bioactive Anti-Depression Compounds in Betel Nut,” Drug Des. Devel. Ther., vol. 15, pp. 4827–4836, doi: 10.2147/DDDT.S335312.
[5]. “SwissSimilarity: A Web Tool for Low to Ultra High Throughput Ligand-Based Virtual Screening | Journal of Chemical Information and Modeling.” https://pubs.acs.org/doi/full/10.1021/acs.jcim.6b00174.
[6]. M. Jing et al., (2018) “A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies,” Nat. Biotechnol., vol. 36, no. 8, pp. 726–737, doi: 10.1038/nbt.4184.
[7]. “AmplexTM Acetylcholine/Acetlycholinesterase Assay Kit.” https://www.thermofisher.cn/order/catalog/product/cn/zh/A12217.
[8]. E. L. Rodriguez et al., (2020) “Affinity Chromatography: A Review of Trends and Developments over the Past 50 Years,” J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci., vol. 1157, p. 122332, doi: 10.1016/j.jchromb.2020.122332.