
Heart Failure in Diabetes Mellitus: the Pathogenesis and Treatment
- 1 Xuzhou Medical University
* Author to whom correspondence should be addressed.
Abstract
People with diabetes mellitus are more likely to develop heart failure, and those with both conditions often experience a worse prognosis compared to heart failure patients without diabetes. This paper will summarize the pathogenesis of diabetic heart failure and propose treatment and prevention options for diabetic patients with heart failure based on the existing literature and data results. Both types of diabetes lead to high blood sugar levels, which, along with diabetes itself, exert different effects on the heart. As time goes on, it causes heart failure. The outcome demonstrates how chronically elevated blood sugar levels can lead to inflammation and accelerate the development of heart failure. Significant roles are also played by oxidative damage, insulin resistance, and other variables. It has been demonstrated that altering one's lifestyle can avoid diabetic heart failure and improve the quality of life for individuals with asymptomatic diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF).
Keywords
Diabetes Mellitus, Heart failure, Diabetic cardiomyopathy, Cardiovascular diseases, Metabolic disease, pathogenesis
[1]. Jia, G., DeMarco, V. G., & Sowers, J. R. (2016). Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nature Reviews Endocrinology, 12(3), 144–153. https://doi.org/10.1038/nrendo.2015.216
[2]. Kenny, H. C., & Abel, E. D. (2020). Heart Failure in Type 2 Diabetes Mellitus: Impact of Glucose Lowering Agents, Heart Failure Therapies and Novel Therapeutic Strategies.
[3]. Skyler, J. S., Bakris, G. L., Bonifacio, E., Darsow, T., Eckel, R. H., Groop, L., Groop, P.-H., Handelsman, Y., Insel, R. A., Mathieu, C., McElvaine, A. T., Palmer, J. P., Pugliese, A., Schatz, D. A., Sosenko, J. M., Wilding, J. P. H., & Ratner, R. E. (2017). Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis. Diabetes, 66(2), 241–255. https://doi.org/10.2337/db16-0806
[4]. Schwinger, R. H. G. (2021). Pathophysiology of heart failure. Cardiovascular Diagnosis and Therapy, 11(1), 263–276. https://doi.org/10.21037/cdt-20-302
[5]. Kenny, H. C., & Abel, E. D. (2020). Heart Failure in Type 2 Diabetes Mellitus: Impact of Glucose Lowering Agents, Heart Failure Therapies and Novel Therapeutic Strategies.
[6]. Junlin Qiu, Shuoming Luo&Zhiguang Zhou. (2020). Research progress of diabetic heart disease. Chinese Journal of Arteriosclerosis(08), 679-687
[7]. Ritchie, R. H., & Abel, E. D. (2020). Basic Mechanisms of Diabetic Heart Disease. Circulation Research, 126(11), 1501–1525. https://doi.org/10.1161/CIRCRESAHA.120.315913
[8]. Jia, G., DeMarco, V. G., & Sowers, J. R. (2016). Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nature Reviews Endocrinology, 12(3), 144–153. https://doi.org/10.1038/nrendo.2015.216
[9]. Jankauskas, S. S., Kansakar, U., Varzideh, F., Wilson, S., Mone, P., Lombardi, A., Gambardella, J., & Santulli, G. (2021). Heart failure in diabetes. Metabolism, 125, 154910. https://doi.org/10.1016/j.metabol.2021.154910
[10]. Wang, L., Cai, Y., Jian, L., Cheung, C. W., Zhang, L., & Xia, Z. (2021). Impact of peroxisome proliferator-activated receptor-α on diabetic cardiomyopathy. Cardiovascular Diabetology, 20(1), 2. https://doi.org/10.1186/s12933-020-01188-0
[11]. Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022). Inflammation in obesity, diabetes, and related disorders. Immunity, 55(1), 31–55. https://doi.org/10.1016/j.immuni.2021.12.013
[12]. Darenskaya, M. A., Kolesnikova, L. I., & Kolesnikov, S. I. (2021). Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction. Bulletin of Experimental Biology and Medicine, 171(2), 179–189. https://doi.org/10.1007/s10517-021-05191-7
[13]. Tsutsui, H., Kinugawa, S., & Matsushima, S. (2011). Oxidative stress and heart failure. 301.
[14]. Nakamura, K., Miyoshi, T., Yoshida, M., Akagi, S., Saito, Y., Ejiri, K., Matsuo, N., Ichikawa, K., Iwasaki, K., Naito, T., Namba, Y., Yoshida, M., Sugiyama, H., & Ito, H. (2022). Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus. Int. J. Mol. Sci.
[15]. Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., Michos, E. D., Miedema, M. D., Muñoz, D., Smith, S. C., Virani, S. S., Williams, K. A., Yeboah, J., & Ziaeian, B. (2019). 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease. Journal of the American College of Cardiology, 74(10), e177–e232. https://doi.org/10.1016/j.jacc.2019.03.010
Cite this article
Xu,Y. (2024). Heart Failure in Diabetes Mellitus: the Pathogenesis and Treatment. Theoretical and Natural Science,64,81-86.
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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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