Volume 115

Published on June 2025

Volume title: Proceedings of the 3rd International Conference on Modern Medicine and Global Health

Conference website: https://2025.icmmgh.org/

ISBN：978-1-80590-193-8(Print) / 978-1-80590-194-5(Online)

Conference date: 20 January 2025

Editor：Sheiladevi Sukumaran

Research Article

Published on 13 June 2025 DOI: 10.54254/2753-8818/2025.24038

The Mechanism of Activating SuM Modified ABN to Improve Memory and Emotional Function in AD

Xiaoyan Liu

DOI: 10.54254/2753-8818/2025.24038

Alzheimer's disease (AD) patients experience declining memory, anxiety, and depression along with a decrease in adult hippocampal neurogenesis (AHN). It's still unclear if improving AHN in the damaged AD brain will improve affective and cognitive performance. According to earlier studies, in two different AD mice models, 5×FAD and 3×Tg-AD, patterned optogenetic activation of the hypothalamic supramammillary nucleus (SuM) increases AHN. Interestingly, these AD mice's memory and emotional deficiencies are restored when SuM-enhanced adult-born neurons (ABNs) are chemogenetic activated. In contrast, behavioral impairments cannot be restored by SuM stimulation alone or by activating ABNs without modifying SuM. This paper will design 3 experiments to explore the mechanism of activating SuM modified ABN to improve memory and emotional function in AD, including who enhances cognitive and emotional function, the activition of microglia and the long-term effect of SuM modified ABNs on memory and emotion function of AD mice.

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Liu,X. (2025). The Mechanism of Activating SuM Modified ABN to Improve Memory and Emotional Function in AD. Theoretical and Natural Science,115,1-9.

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