References
[1]. Li, Y.D., Luo, Y.J., Song, J. (2023). Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer’s disease. Cell Stem Cell, 30, 415–432.
[2]. Li, Y.D., Luo, Y.J., Song, J. (2022). Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior. Nature neuroscience,25,630-645.
[3]. Moreno-Jime´nez, E.P., Flor-Garcı´a, M., Terreros-Roncal, J., Ra´bano, A., Cafini, F., Pallas-Bazarra, N., A ´vila, J., and Llorens-Martı´n, M. (2019). Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease. Nat. Med. 25, 554–560.
[4]. Tobin, M.K., Musaraca, K., Disouky, A., Shetti, A., Bheri, A., Honer, W.G., Kim, N., Dawe, R.J., Bennett, D.A., Arfanakis, K., and Lazarov, O. (2019). Human hippocampal neurogenesis persists in aged adults and Alzheimer’s disease patients. Cell Stem Cell 24, 974–982.e3.
[5]. Zhang, X., Wei, X., Mei, Y., Wang, D., Wang, J., Zhang, Y., Li, X., Gu, Y., Peng, G., and Sun, B. (2021). Modulating adult neurogenesis affects syn aptic plasticity and cognitive functions in mouse models of Alzheimer’s disease. Stem Cell Rep. 16, 3005–3019.
[6]. Wang, W.B., Li, Y.Z., Ma, F.L., Zhong, L., et al. (2023). Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer’s disease model by restoring BDNF signaling. Brain, Behavior, and Immunity, 113, 275-288.
[7]. Zhu, H., Aryal, D.K., Olsen, R.H., Urban, D.J., Swearingen, A., Forbes, S., Roth, B.L., and Hochgeschwender, U. (2016). Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice. Genesis 54, 439–446.
[8]. Sarlus, H., and Heneka, M.T. (2017). Microglia in Alzheimer’s disease. J. Clin. Invest. 127, 3240–3249.
[9]. Franco-Bocanegra, D.K., McAuley, C., Nicoll, J.A.R., and Boche, D. (2019). Molecular mechanisms of microglial motility: changes in ageing and Alzheimer’s disease. Cells 8, 639.
[10]. Gonza´lez Ibanez, F., Picard, K., Bordeleau, M., Sharma, K., Bisht, K., and Tremblay, M.E `. (2019). Immunofluorescence staining using IBA1 and TMEM119 for microglial density, morphology, and peripheral myeloid cell infiltration analysis in mouse brain. J. Vis. Exp.
[11]. Leng F, Edison P. (2021). Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Nat Rev Neurol, 17(3), 157-172.
[12]. Hu, J., Chen, Q., Zhu, H.R. (2023). Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease. Neuron, 111(1), 15- 29.
[13]. Tong, L., Han, S.S., Xue, Y. (2023). Single cell in vivo optogenetic stimulation by two-photon excitation fluorescence transfer. iScience,107857.
Cite this article
Liu,X. (2025). The Mechanism of Activating SuM Modified ABN to Improve Memory and Emotional Function in AD. Theoretical and Natural Science,115,1-9.
Data availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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References
[1]. Li, Y.D., Luo, Y.J., Song, J. (2023). Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer’s disease. Cell Stem Cell, 30, 415–432.
[2]. Li, Y.D., Luo, Y.J., Song, J. (2022). Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior. Nature neuroscience,25,630-645.
[3]. Moreno-Jime´nez, E.P., Flor-Garcı´a, M., Terreros-Roncal, J., Ra´bano, A., Cafini, F., Pallas-Bazarra, N., A ´vila, J., and Llorens-Martı´n, M. (2019). Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease. Nat. Med. 25, 554–560.
[4]. Tobin, M.K., Musaraca, K., Disouky, A., Shetti, A., Bheri, A., Honer, W.G., Kim, N., Dawe, R.J., Bennett, D.A., Arfanakis, K., and Lazarov, O. (2019). Human hippocampal neurogenesis persists in aged adults and Alzheimer’s disease patients. Cell Stem Cell 24, 974–982.e3.
[5]. Zhang, X., Wei, X., Mei, Y., Wang, D., Wang, J., Zhang, Y., Li, X., Gu, Y., Peng, G., and Sun, B. (2021). Modulating adult neurogenesis affects syn aptic plasticity and cognitive functions in mouse models of Alzheimer’s disease. Stem Cell Rep. 16, 3005–3019.
[6]. Wang, W.B., Li, Y.Z., Ma, F.L., Zhong, L., et al. (2023). Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer’s disease model by restoring BDNF signaling. Brain, Behavior, and Immunity, 113, 275-288.
[7]. Zhu, H., Aryal, D.K., Olsen, R.H., Urban, D.J., Swearingen, A., Forbes, S., Roth, B.L., and Hochgeschwender, U. (2016). Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice. Genesis 54, 439–446.
[8]. Sarlus, H., and Heneka, M.T. (2017). Microglia in Alzheimer’s disease. J. Clin. Invest. 127, 3240–3249.
[9]. Franco-Bocanegra, D.K., McAuley, C., Nicoll, J.A.R., and Boche, D. (2019). Molecular mechanisms of microglial motility: changes in ageing and Alzheimer’s disease. Cells 8, 639.
[10]. Gonza´lez Ibanez, F., Picard, K., Bordeleau, M., Sharma, K., Bisht, K., and Tremblay, M.E `. (2019). Immunofluorescence staining using IBA1 and TMEM119 for microglial density, morphology, and peripheral myeloid cell infiltration analysis in mouse brain. J. Vis. Exp.
[11]. Leng F, Edison P. (2021). Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Nat Rev Neurol, 17(3), 157-172.
[12]. Hu, J., Chen, Q., Zhu, H.R. (2023). Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease. Neuron, 111(1), 15- 29.
[13]. Tong, L., Han, S.S., Xue, Y. (2023). Single cell in vivo optogenetic stimulation by two-photon excitation fluorescence transfer. iScience,107857.