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Gestational Diabetes Mellitus Pathogenesis and Comprehensive Management Strategies
- 1 University of Illinois Urbana-Champaign, Urbana-Champaign, Illinois, USA
* Author to whom correspondence should be addressed.
Abstract
A common pregnancy problem, gestational diabetes mellitus (GDM), is caused by impaired glucose and carbohydrate metabolism that is initially identified during pregnancy. Because GDM has a major influence on the health of mothers and infants, its rising prevalence has made it a serious public health concern. The multifaceted pathophysiology of GDM, which includes insulin resistance, genetic predisposition, hormonal changes, and lifestyle variables, is reviewed in this article. It highlights the serious short-term hazards, such macrosomia and gestational hypertension, as well as the long-term effects, like a higher chance of type 2 diabetes in both mothers and their children. Effective management of GDM requires a multifaceted approach, encompassing dietary adjustments, physical activity, regular blood glucose monitoring, and pharmacological interventions when necessary. Public health strategies promoting low-glycemic index and high-fiber diets, alongside interventions targeting obesity and physical inactivity, are vital to reducing GDM incidence. Furthermore, this study highlights gaps in understanding the influence of social, cultural, and economic factors on GDM management and emphasizes the need for future research to develop inclusive, personalized strategies to address these disparities effectively.
Keywords
Gestational diabetes mellitus, pathogenesis, pregnant women, public health interventions, WHO
[1]. Sweeting, A., Wong, J., Murphy, H. R., & Ross, G. P. (2022). A clinical update on gestational diabetes mellitus. Endocrine Reviews, 43(5), 763–793. https://doi.org/10.1210/endrev/bnac003
[2]. Lo, J. C., Feigenbaum, S. L., Escobar, G. J., Yang, J., Crites, Y. M., & Ferrara, A. (2006). Increased prevalence of gestational diabetes mellitus among women with diagnosed polycystic ovary syndrome: A population-based study. Diabetes Care, 29(8), 1915–1917. https://doi.org/10.2337/dc06-0877
[3]. Hu, J., et al. (2021). Association of maternal lipid profile and gestational diabetes mellitus: A systematic review and meta-analysis of 292 studies and 97,880 women. eClinicalMedicine, 34, 100830.
[4]. Contreras-Duarte, S., Carvajal, L., Fuenzalida, B., Cantin, C., Sobrevia, L., & Leiva, A. (2019). Maternal dyslipidaemia in pregnancy with gestational diabetes mellitus: Possible impact on foetoplacental vascular function and lipoproteins in the neonatal circulation. Current Vascular Pharmacology, 17(1), 52–71. https://doi.org/10.2174/1570161115666171116154247
[5]. Su, S., Zhang, E., Gao, S., et al. (2024). Associations of remnant cholesterol in early pregnancy with gestational diabetes mellitus risk: A prospective birth cohort study. Lipids in Health and Disease, 23, 243. https://doi.org/10.1186/s12944-024-02230-w
[6]. Zhu, Z., Wang, K., Hao, X., Chen, L., Liu, Z., & Wang, C. (2022). Causal graph among serum lipids and glycemic traits: A Mendelian randomization study. Diabetes, 71(8), 1818–1826. https://doi.org/10.2337/db21-0734
[7]. Cleary-Goldman, J., Malone, F. D., Vidaver, J., Ball, R. H., Nyberg, D. A., Comstock, C. H., Saade, G. R., Eddleman, K. A., Klugman, S., Dugoff, L., Timor-Tritsch, I. E., Craigo, S. D., Carr, S. R., Wolfe, H. M., Bianchi, D. W., & D'Alton, M. (2005). Impact of maternal age on obstetric outcome. Obstetrics & Gynecology, 105(5 Part 1), 983–990. https://doi.org/10.1097/01.AOG.0000158118.75532.51
[8]. Yamamoto, J. M., Kellett, J. E., Balsells, M., Garcia-Patterson, A., Hadar, E., Sola, I., & Corcoy, R. (2018). Gestational diabetes mellitus and diet: A systematic review and meta-analysis of randomized controlled trials examining the impact of modified dietary interventions on maternal glucose control and neonatal birth weight. Diabetes Care, 41(7), 1346–1361. https://doi.org/10.2337/dc18-0191
[9]. Persson, M., Norman, M., & Hanson, U. (2009). Obstetric and perinatal outcomes in Type 1 diabetic pregnancies: A large, population-based study. Diabetes Care, 32(11), 2005–2009. https://doi.org/10.2337/dc09-0656
[10]. Zakaria, H. The Role of Lifestyle Interventions in the Prevention and Treatment of Gestational Diabetes Mellitus, Oct 01, 2024
[11]. World Health Organization. (2021). Global Diabetes Compact. Geneva: World Health Organization. Retrieved from https://www.who.int/news-room/fact-sheets/detail/diabetes
Cite this article
Yu,X. (2025). Gestational Diabetes Mellitus Pathogenesis and Comprehensive Management Strategies. Theoretical and Natural Science,96,1-6.
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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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Volume title: Proceedings of the 5th International Conference on Biological Engineering and Medical Science
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