The Impact of 40 Hz Gamma Frequency Entrainment on Alzheimer's Disease: A Therapeutic Perspective

Research Article
Open access

The Impact of 40 Hz Gamma Frequency Entrainment on Alzheimer's Disease: A Therapeutic Perspective

Suqian Yao 1*
  • 1 Biological Science, University of California Irvine, Irvine, USA    
  • *corresponding author suqiany@uci.edu
Published on 20 June 2025 | https://doi.org/10.54254/2753-8818/2025.24214
TNS Vol.116
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-80590-197-6
ISBN (Online): 978-1-80590-198-3

Abstract

This study investigates the relationship between 40 Hz gamma frequency entrainment and microglial activation in Alzheimer's disease, focusing on how brain wave stimulation affects amyloid-beta clearance. It analyzes the correlation between gamma entrainment and microglial phenotype transitions, shedding light on potential therapeutic approaches in a changing medical landscape. Additionally, the research examines whether gamma entrainment can facilitate enhanced amyloid-beta clearance through microglial activation. The study's insights inform medical practitioners, researchers, and healthcare providers on enhancing treatment efficacy, reducing neurodegeneration, and maintaining cognitive function in the context of increasing Alzheimer's disease prevalence. It contributes to the discourse on neurodegenerative disease treatment amid technological advancement.

Keywords:

Gamma Entrainment, Alzheimer's Disease, Microglia, Amyloid-Beta, Neurodegeneration.

Yao,S. (2025). The Impact of 40 Hz Gamma Frequency Entrainment on Alzheimer's Disease: A Therapeutic Perspective. Theoretical and Natural Science,116,52-56.
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References

[1]. Brand, A.L. et al. The performance of plasma amyloid beta measurements in identifying amy-loid plaques in Alzheimer’s disease. Alz Res Therapy 14, 195 (2022). https://doi.org/10.1186/s13195-022-01117-1

[2]. Li, Y. et al. Validation of Plasma Amyloid-beta 42/40 for Detecting Alzheimer Disease Amy-loid Plaques. Neurology 98, e688-e699 (2022). https://doi.org/10.1212/WNL.0000000000013211

[3]. Iaccarino, H.F. et al. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature 540, 230-235 (2016). https://doi.org/10.1038/nature20587

[4]. He, Y. et al. IL-4 Switches Microglia/macrophage M1/M2 Polarization and Alleviates Neurological Damage by Modulating the JAK1/STAT6 Pathway Following ICH. Neuroscience 437, 161-171 (2020). https://doi.org/10.1016/j.neuroscience.2020.03.008

[5]. Wu, H. et al. Mer Regulates Microglial/Macrophage M1/M2 Polarization and Alleviates Neuroinflammation Following Traumatic Brain Injury. J Neuroinflammation 18, 2 (2021). https://doi.org/10.1186/s12974-020-02041-7


Cite this article

Yao,S. (2025). The Impact of 40 Hz Gamma Frequency Entrainment on Alzheimer's Disease: A Therapeutic Perspective. Theoretical and Natural Science,116,52-56.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 3rd International Conference on Modern Medicine and Global Health

ISBN:978-1-80590-197-6(Print) / 978-1-80590-198-3(Online)
Editor:Sheiladevi Sukumaran
Conference website: https://2025.icmmgh.org/
Conference date: 20 January 2025
Series: Theoretical and Natural Science
Volume number: Vol.116
ISSN:2753-8818(Print) / 2753-8826(Online)

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References

[1]. Brand, A.L. et al. The performance of plasma amyloid beta measurements in identifying amy-loid plaques in Alzheimer’s disease. Alz Res Therapy 14, 195 (2022). https://doi.org/10.1186/s13195-022-01117-1

[2]. Li, Y. et al. Validation of Plasma Amyloid-beta 42/40 for Detecting Alzheimer Disease Amy-loid Plaques. Neurology 98, e688-e699 (2022). https://doi.org/10.1212/WNL.0000000000013211

[3]. Iaccarino, H.F. et al. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature 540, 230-235 (2016). https://doi.org/10.1038/nature20587

[4]. He, Y. et al. IL-4 Switches Microglia/macrophage M1/M2 Polarization and Alleviates Neurological Damage by Modulating the JAK1/STAT6 Pathway Following ICH. Neuroscience 437, 161-171 (2020). https://doi.org/10.1016/j.neuroscience.2020.03.008

[5]. Wu, H. et al. Mer Regulates Microglial/Macrophage M1/M2 Polarization and Alleviates Neuroinflammation Following Traumatic Brain Injury. J Neuroinflammation 18, 2 (2021). https://doi.org/10.1186/s12974-020-02041-7