The Role and Relationship of S1P and Reelin in the Horizontal-to-Radial Transitioning of Newly Generated DGCs in the Hippocampus

Research Article
Open access

The Role and Relationship of S1P and Reelin in the Horizontal-to-Radial Transitioning of Newly Generated DGCs in the Hippocampus

Huanran Yu 1*
  • 1 Jordan High School, Fulshear, USA    
  • *corresponding author henryethanyu@gmail.com
Published on 20 June 2025 | https://doi.org/10.54254/2753-8818/2025.24218
TNS Vol.116
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-80590-197-6
ISBN (Online): 978-1-80590-198-3

Abstract

This work studies the functions of sphingosine-1-phosphate (S1P) and Reelin in the horizontal-to-radial transitioning of freshly formed dentate granule cells (DGCs) in the hippocampus. We determined the location of S1P synthesis in the dentate gyrus, investigated the cooperative character of S1P and Reelin signaling, and looked at the regulatory link between the two. According to our research, the polymorphic layer or granule cell of the dentate gyrus is where S1P is formed. Moreover, we show that the horizontal-to-radial transitioning of DGCs is facilitated by the joint contribution of S1P and Reelin signaling. Crucially, our findings imply that Reelin participates in this developmental process upstream of S1P. These discoveries deepen our knowledge of hippocampus neurogenesis and could have consequences for neurological conditions linked to abnormal.

Keywords:

Neurogenesis, Hippocampus, Dentate Gyrus

Yu,H. (2025). The Role and Relationship of S1P and Reelin in the Horizontal-to-Radial Transitioning of Newly Generated DGCs in the Hippocampus. Theoretical and Natural Science,116,71-77.
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References

[1]. Abbott, L. C., & Nigussie, F. (2019). Adult neurogenesis in the mammalian dentate gyrus. Anatomia, Histologia, Embryologia, 49(1), 3–16. https://doi.org/10.1111/ahe.12496

[2]. Amaral, D. G., Scharfman, H. E., & Lavenex, P. (2007). The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies). Progress in brain research, 163, 3–22. https://doi.org/10.1016/S0079-6123(07)63001-5

[3]. 3Basler, L., Gerdes, S., Wolfer, D. P., & Slomianka, L. (2017). Sampling the mouse hippocampal dentate gyrus. Frontiers in Neuroanatomy, 11(2017). https://doi.org/10.3389/fnana.2017.00123

[4]. 3Basler, L., Gerdes, S., Wolfer, D. P., & Slomianka, L. (2017). Sampling the mouse hippocampal dentate gyrus. Frontiers in Neuroanatomy, 11(2017). https://doi.org/10.3389/fnana.2017.00123

[5]. Teixeira, C. M., Kron, M., Núria Masachs, Zhang, H., Lagace, D. C., Martı́nezA., Reillo, I., Duan, X., Bosch, C., Lluı́s Pujadas, Brunso, L., Song, H., Eisch, A. J., BorrellV., Howell, B. W., Parent, J. M., & Soriano, E. (2012). Cell-Autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus. The Journal of Neuroscience, 32(35), 12051–12065. https://doi.org/10.1523/jneurosci.1857-12.2012

[6]. Yang, C.-H., Di Antonio, A., Kirschen, G. W., Varma, P., Hsieh, J., & Ge, S. (2020). Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain. Cell Reports, 30(4), 959-968.e3. https://doi.org/10.1016/j.celrep.2019.12.084

Cite this article

Yu,H. (2025). The Role and Relationship of S1P and Reelin in the Horizontal-to-Radial Transitioning of Newly Generated DGCs in the Hippocampus. Theoretical and Natural Science,116,71-77.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 3rd International Conference on Modern Medicine and Global Health

ISBN：978-1-80590-197-6(Print) / 978-1-80590-198-3(Online)
Editor：Sheiladevi Sukumaran
Conference website: https://2025.icmmgh.org/
Conference date: 20 January 2025
Series: Theoretical and Natural Science
Volume number: Vol.116
ISSN：2753-8818(Print) / 2753-8826(Online)

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References

[1]. Abbott, L. C., & Nigussie, F. (2019). Adult neurogenesis in the mammalian dentate gyrus. Anatomia, Histologia, Embryologia, 49(1), 3–16. https://doi.org/10.1111/ahe.12496

[2]. Amaral, D. G., Scharfman, H. E., & Lavenex, P. (2007). The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies). Progress in brain research, 163, 3–22. https://doi.org/10.1016/S0079-6123(07)63001-5

[3]. 3Basler, L., Gerdes, S., Wolfer, D. P., & Slomianka, L. (2017). Sampling the mouse hippocampal dentate gyrus. Frontiers in Neuroanatomy, 11(2017). https://doi.org/10.3389/fnana.2017.00123

[4]. 3Basler, L., Gerdes, S., Wolfer, D. P., & Slomianka, L. (2017). Sampling the mouse hippocampal dentate gyrus. Frontiers in Neuroanatomy, 11(2017). https://doi.org/10.3389/fnana.2017.00123

[5]. Teixeira, C. M., Kron, M., Núria Masachs, Zhang, H., Lagace, D. C., Martı́nezA., Reillo, I., Duan, X., Bosch, C., Lluı́s Pujadas, Brunso, L., Song, H., Eisch, A. J., BorrellV., Howell, B. W., Parent, J. M., & Soriano, E. (2012). Cell-Autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus. The Journal of Neuroscience, 32(35), 12051–12065. https://doi.org/10.1523/jneurosci.1857-12.2012

[6]. Yang, C.-H., Di Antonio, A., Kirschen, G. W., Varma, P., Hsieh, J., & Ge, S. (2020). Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain. Cell Reports, 30(4), 959-968.e3. https://doi.org/10.1016/j.celrep.2019.12.084

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