Gastric cancer stem cell: Carcinogenesis and targeted personalized therapies of cancer stem cell

Research Article
Open access

Gastric cancer stem cell: Carcinogenesis and targeted personalized therapies of cancer stem cell

Zhou Zhuanghan 1*
  • 1 Wenzhou-Kean University    
  • *corresponding author Zhouzhu@kean.edu
Published on 20 December 2023 | https://doi.org/10.54254/2753-8818/21/20230801
TNS Vol.21
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-83558-215-2
ISBN (Online): 978-1-83558-216-9

Abstract

Gastric cancer (GC) is one of the most common cancers in worldwide range which ranks fifth, and it is also third most common cancerous death reason. Although there has been a decline in the rate of incidence and mortality over recent fifty years, cure for GC is extremely hard to achieve. The symptoms are not conspicuous at early stage of the GC patients usually, which is the reason GC is diagnosed at terminal stage. And it is worse that the prognosis effect is outrageously bad, the median survival times are mostly less than a year. Under this condition, prevention is the most efficient method to reduce the incidence and mortality, meanwhile, the application of newly emerged therapy should be attached importance to GC. To create accurate treatment to achieve this goal, it is necessary to comprehend the mechanism of the carcinogenesis, and mechanism of cancer development, the critical transformation points derived from those mechanism will divide the different methodology applying period. This article mainly focuses on the cancer stem cell (CSC) aspect of carcinogenesis, cancer development to inform the points which can be utilized to intervene and new therapy method.

Keywords:

gastric cancer, carcinogenesis, cancer stem cell (CSC), targeted personalized therapy

Zhuanghan,Z. (2023). Gastric cancer stem cell: Carcinogenesis and targeted personalized therapies of cancer stem cell. Theoretical and Natural Science,21,15-20.
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References

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[5]. CORREA, P., & PIAZUELO, M. B. (2011). The gastric precancerous cascade. Journal of Digestive Diseases, 13(1), 2–9. https://doi.org/10.1111/j.1751-2980.2011.00550.x

[6]. Johnston, F. M., & Beckman, M. (2019). Updates on management of Gastric Cancer. Current Oncology Reports, 21(8). https://doi.org/10.1007/s11912-019-0820-4

[7]. Rugge, M., Fassan, M., & Graham, D. Y. (2015). Epidemiology of Gastric Cancer. Gastric Cancer, 23–34.Return to ref 9 in article

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[9]. Polk, D., Peek, R. Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer 10, 403–414 (2010). https://doi.org/10.1038/nrc2857

[10]. Jencks DS, Adam JD, Borum ML, Koh JM, Stephen S, Doman DB. Overview of Current Concepts in Gastric Intestinal Metaplasia and Gastric Cancer. Gastroenterol Hepatol (N Y). 2018 Feb;14(2):92-101. PMID: 29606921; PMCID: PMC5866308.

[11]. Kapadia, C. R. (2003). Gastric atrophy, metaplasia, and dysplasia. Journal of Clinical Gastroenterology, 36. https://doi.org/10.1097/00004836-200305001-00006

[12]. Raza M, Bhatt H. Atrophic Gastritis. [Updated 2022 Jul 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK563275/

[13]. Correa P, Piazuelo MB. The gastric precancerous cascade. J Dig Dis. 2012 Jan;13(1):2-9. doi: 10.1111/j.1751-2980.2011.00550.x. PMID: 22188910; PMCID: PMC3404600.

[14]. McDonald, S. A. C., Greaves, L. C., Gutierrez–Gonzalez, L., Rodriguez–Justo, M., Deheragoda, M., Leedham, S. J., Taylor, R. W., Lee, C. Y., Preston, S. L., Lovell, M., Hunt, T., Elia, G., Oukrif, D., Harrison, R., Novelli, M. R., Mitchell, I., Stoker, D. L., Turnbull, D. M., Jankowski, J. A. Z., & Wright, N. A. (2008). Mechanisms of field cancerization in the human stomach: The expansion and spread of mutated gastric stem cells. Gastroenterology, 134(2), 500–510. https://doi.org/10.1053/j.gastro.2007.11.035

[15]. Jonaitis, P., Kupcinskas, L., & Kupcinskas, J. (2021). Molecular alterations in gastric intestinal metaplasia. International Journal of Molecular Sciences, 22(11), 5758. https://doi.org/10.3390/ijms22115758

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[20]. Baek, D.H., Kim, G.H., Park, D.Y. et al. Gastric epithelial dysplasia: characteristics and long-term follow-up results after endoscopic resection according to morphological categorization. BMC Gastroenterol 15, 17 (2015). https://doi.org/10.1186/s12876-015-0249-7

[21]. Correa, P. (2004). Is gastric cancer preventable? Gut, 53(9), 1217–1219. https://doi.org/10.1136/gut.2004.039834

[22]. Min J, Zhang C, Bliton RJ, Caldwell B, Caplan L, Presentation KS, Park DJ, Kong SH, Lee HS, Washington MK, Kim WH, Lau KS, Magness ST, Lee HJ, Yang HK, Goldenring JR, Choi E. Dysplastic Stem Cell Plasticity Functions as a Driving Force for Neoplastic Transformation of Precancerous Gastric Mucosa. Gastroenterology. 2022 Oct;163(4):875-890. doi: 10.1053/j.gastro.2022.06.021. Epub 2022 Jun 11. PMID: 35700772; PMCID: PMC9509466.

[23]. Oue, N., Sentani, K., Sakamoto, N. et al. Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells. Int J Clin Oncol 24, 771–778 (2019). https://doi.org/10.1007/s10147-019-01443-9

[24]. Oue N, Sentani K, Sakamoto N, Yasui W. Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype. Cancer Sci. 2015 Aug;106(8):951-8. doi: 10.1111/cas.12706. Epub 2015 Jul 7. PMID: 26033320; PMCID: PMC4556382.

[25]. Ma J, Shen H, Kapesa L, Zeng S. Lauren classification and individualized chemotherapy in gastric cancer. Oncol Lett. 2016 May;11(5):2959-2964. doi: 10.3892/ol.2016.4337. Epub 2016 Mar 16. PMID: 27123046; PMCID: PMC4840723.

[26]. Qiu MZ, Cai MY, Zhang DS, Wang ZQ, Wang DS, Li YH, Xu RH. Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China. J Transl Med. 2013 Mar 6;11:58. doi: 10.1186/1479-5876-11-58. PMID: 23497313; PMCID: PMC3600019.

[27]. Stock, M., & Otto, F. (2005). Gene deregulation in Gastric Cancer. Gene, 360(1), 1–19. https://doi.org/10.1016/j.gene.2005.06.026.

[28]. Nobili S, Bruno L, Landini I, Napoli C, Bechi P, Tonelli F, Rubio CA, Mini E, Nesi G. Genomic and genetic alterations influence the progression of gastric cancer. World J Gastroenterol. 2011 Jan 21;17(3):290-9. doi: 10.3748/wjg.v17.i3.290. PMID: 21253387; PMCID: PMC3022288.

[29]. Correa, P. (2004). Is gastric cancer preventable? Gut, 53(9), 1217–1219. https://doi.org/10.1136/gut.2004.039834

[30]. Rugge, M., Fassan, M., & Graham, D. Y. (2015). Epidemiology of Gastric Cancer. Gastric Cancer, 23–34.

[31]. Panzini I, Gianni L, Fattori PP et al. Adjuvant chemotherapy in gastric cancer: a meta-analysis of randomized trials and a comparison with previous meta-analyses. Tumori88(1), 21–27 (2002).

[32]. Zeng S, Shen WH, Liu L. Senescence and cancer. Cancer Transl Med. (2018) 4:70–4. doi: 10.4103/ctm.ctm_22_18.

[33]. Hosoya N, Miyagawa K. Targeting DNA damage response in cancer therapy. Cancer Sci. (2014) 105:370–88. doi: 10.1111/cas.12366.

[34]. Ruhland MK, Coussens LM, Stewart SA. Senescence and cancer: an evolving inflammatory paradox. Biochim Biophys Acta. (2016) 1865:14–22. doi: 10.1016/j.bbcan.2015.10.001.

[35]. Coppé J-P, Desprez P-Y, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. (2010) 5:99–118. doi: 10.1146/annurev-pathol-121808-102144.

[36]. Kang T-W, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature. (2011) 479:547–51. doi: 10.1038/nature10599.

[37]. Brungs, D., Aghmesheh, M., Vine, K.L. et al. Gastric cancer stem cells: evidence, potential markers, and clinical implications. J Gastroenterol 51, 313–326 (2016). https://doi.org/10.1007/s00535-015-1125-5.

[38]. Singh, S. R. (2013). Gastric cancer stem cells: A novel therapeutic target. Cancer Letters, 338(1), 110–119. https://doi.org/10.1016/j.canlet.2013.03.035

Cite this article

Zhuanghan,Z. (2023). Gastric cancer stem cell: Carcinogenesis and targeted personalized therapies of cancer stem cell. Theoretical and Natural Science,21,15-20.

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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 3rd International Conference on Biological Engineering and Medical Science

ISBN：978-1-83558-215-2(Print) / 978-1-83558-216-9(Online)
Editor：Alan Wang
Conference website: https://www.icbiomed.org/
Conference date: 2 September 2023
Series: Theoretical and Natural Science
Volume number: Vol.21
ISSN：2753-8818(Print) / 2753-8826(Online)

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References

[1]. Shackleton, M., Quintana, E., Fearon, E. R., & Morrison, S. J. (2009). Heterogeneity in cancer: Cancer stem cells versus Clonal Evolution. Cell, 138(5), 822–829. https://doi.org/10.1016/j.cell.2009.08.017

[2]. Lee, G., & R Hall, R. (2016). Cancer stem cells: Cellular plasticity, niche, and its clinical relevance. Journal of Stem Cell Research & Therapy, 06(10). https://doi.org/10.4172/2157-7633.1000363

[3]. Brungs, D., Aghmesheh, M., Vine, K. L., Becker, T. M., Carolan, M. G., & Ranson, M. (2015). Gastric cancer stem cells: Evidence, potential markers, and clinical implications. Journal of Gastroenterology, 51(4), 313–326. https://doi.org/10.1007/s00535-015-1125-5

[4]. Vlashi, E., & Pajonk, F. (2015). Cancer stem cells, cancer cell plasticity and radiation therapy. Seminars in Cancer Biology, 31, 28–35. https://doi.org/10.1016/j.semcancer.2014.07.001

[5]. CORREA, P., & PIAZUELO, M. B. (2011). The gastric precancerous cascade. Journal of Digestive Diseases, 13(1), 2–9. https://doi.org/10.1111/j.1751-2980.2011.00550.x

[6]. Johnston, F. M., & Beckman, M. (2019). Updates on management of Gastric Cancer. Current Oncology Reports, 21(8). https://doi.org/10.1007/s11912-019-0820-4

[7]. Rugge, M., Fassan, M., & Graham, D. Y. (2015). Epidemiology of Gastric Cancer. Gastric Cancer, 23–34.Return to ref 9 in article

[8]. Han, J. P., Hong, S. J., & Kim, H. K. (2014). Long-term outcomes of early gastric cancer diagnosed as mixed adenocarcinoma after endoscopic submucosal dissection. JGH., 30(2), 316–320. https://doi.org/10.1111/jgh.12838.

[9]. Polk, D., Peek, R. Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer 10, 403–414 (2010). https://doi.org/10.1038/nrc2857

[10]. Jencks DS, Adam JD, Borum ML, Koh JM, Stephen S, Doman DB. Overview of Current Concepts in Gastric Intestinal Metaplasia and Gastric Cancer. Gastroenterol Hepatol (N Y). 2018 Feb;14(2):92-101. PMID: 29606921; PMCID: PMC5866308.

[11]. Kapadia, C. R. (2003). Gastric atrophy, metaplasia, and dysplasia. Journal of Clinical Gastroenterology, 36. https://doi.org/10.1097/00004836-200305001-00006

[12]. Raza M, Bhatt H. Atrophic Gastritis. [Updated 2022 Jul 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK563275/

[13]. Correa P, Piazuelo MB. The gastric precancerous cascade. J Dig Dis. 2012 Jan;13(1):2-9. doi: 10.1111/j.1751-2980.2011.00550.x. PMID: 22188910; PMCID: PMC3404600.

[14]. McDonald, S. A. C., Greaves, L. C., Gutierrez–Gonzalez, L., Rodriguez–Justo, M., Deheragoda, M., Leedham, S. J., Taylor, R. W., Lee, C. Y., Preston, S. L., Lovell, M., Hunt, T., Elia, G., Oukrif, D., Harrison, R., Novelli, M. R., Mitchell, I., Stoker, D. L., Turnbull, D. M., Jankowski, J. A. Z., & Wright, N. A. (2008). Mechanisms of field cancerization in the human stomach: The expansion and spread of mutated gastric stem cells. Gastroenterology, 134(2), 500–510. https://doi.org/10.1053/j.gastro.2007.11.035

[15]. Jonaitis, P., Kupcinskas, L., & Kupcinskas, J. (2021). Molecular alterations in gastric intestinal metaplasia. International Journal of Molecular Sciences, 22(11), 5758. https://doi.org/10.3390/ijms22115758

[16]. DIXON, M. F. (2001). Prospects for intervention in gastric carcinogenesis: Reversibility of gastric atrophy and intestinal metaplasia. Gut, 49(1), 2–4. https://doi.org/10.1136/gut.49.1.2

[17]. Sung, J. K. (2016). Diagnosis and management of Gastric dysplasia. The Korean Journal of Internal Mdicine, 31(2), 201–209. https://doi.org/10.3904/kjim.2016.021

[18]. Rugge, Massimo M.D.; Correa, Pelayo M.D.; Dixon, Michael F. M.D.; Hattori, Takanori; Leandro, Gioacchino M.D.; Lewin, Klaus M.D.; Riddell, Robert H. M.D.; Sipponen, Pentii M.D.; Watanabe, Hidenobu M.D. Gastric Dysplasia: The Padova International Classification. The American Journal of Surgical Pathology 24(2):p 167-176, February 2000.

[19]. Srivastava, A., & Lauwers, G. Y. (2008). Gastric epithelial dysplasia: The Western Perspective. Digestive and Liver Disease, 40(8), 641–649. https://doi.org/10.1016/j.dld.2008.02.039

[20]. Baek, D.H., Kim, G.H., Park, D.Y. et al. Gastric epithelial dysplasia: characteristics and long-term follow-up results after endoscopic resection according to morphological categorization. BMC Gastroenterol 15, 17 (2015). https://doi.org/10.1186/s12876-015-0249-7

[21]. Correa, P. (2004). Is gastric cancer preventable? Gut, 53(9), 1217–1219. https://doi.org/10.1136/gut.2004.039834

[22]. Min J, Zhang C, Bliton RJ, Caldwell B, Caplan L, Presentation KS, Park DJ, Kong SH, Lee HS, Washington MK, Kim WH, Lau KS, Magness ST, Lee HJ, Yang HK, Goldenring JR, Choi E. Dysplastic Stem Cell Plasticity Functions as a Driving Force for Neoplastic Transformation of Precancerous Gastric Mucosa. Gastroenterology. 2022 Oct;163(4):875-890. doi: 10.1053/j.gastro.2022.06.021. Epub 2022 Jun 11. PMID: 35700772; PMCID: PMC9509466.

[23]. Oue, N., Sentani, K., Sakamoto, N. et al. Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells. Int J Clin Oncol 24, 771–778 (2019). https://doi.org/10.1007/s10147-019-01443-9

[24]. Oue N, Sentani K, Sakamoto N, Yasui W. Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype. Cancer Sci. 2015 Aug;106(8):951-8. doi: 10.1111/cas.12706. Epub 2015 Jul 7. PMID: 26033320; PMCID: PMC4556382.

[25]. Ma J, Shen H, Kapesa L, Zeng S. Lauren classification and individualized chemotherapy in gastric cancer. Oncol Lett. 2016 May;11(5):2959-2964. doi: 10.3892/ol.2016.4337. Epub 2016 Mar 16. PMID: 27123046; PMCID: PMC4840723.

[26]. Qiu MZ, Cai MY, Zhang DS, Wang ZQ, Wang DS, Li YH, Xu RH. Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China. J Transl Med. 2013 Mar 6;11:58. doi: 10.1186/1479-5876-11-58. PMID: 23497313; PMCID: PMC3600019.

[27]. Stock, M., & Otto, F. (2005). Gene deregulation in Gastric Cancer. Gene, 360(1), 1–19. https://doi.org/10.1016/j.gene.2005.06.026.

[28]. Nobili S, Bruno L, Landini I, Napoli C, Bechi P, Tonelli F, Rubio CA, Mini E, Nesi G. Genomic and genetic alterations influence the progression of gastric cancer. World J Gastroenterol. 2011 Jan 21;17(3):290-9. doi: 10.3748/wjg.v17.i3.290. PMID: 21253387; PMCID: PMC3022288.

[29]. Correa, P. (2004). Is gastric cancer preventable? Gut, 53(9), 1217–1219. https://doi.org/10.1136/gut.2004.039834

[30]. Rugge, M., Fassan, M., & Graham, D. Y. (2015). Epidemiology of Gastric Cancer. Gastric Cancer, 23–34.

[31]. Panzini I, Gianni L, Fattori PP et al. Adjuvant chemotherapy in gastric cancer: a meta-analysis of randomized trials and a comparison with previous meta-analyses. Tumori88(1), 21–27 (2002).

[32]. Zeng S, Shen WH, Liu L. Senescence and cancer. Cancer Transl Med. (2018) 4:70–4. doi: 10.4103/ctm.ctm_22_18.

[33]. Hosoya N, Miyagawa K. Targeting DNA damage response in cancer therapy. Cancer Sci. (2014) 105:370–88. doi: 10.1111/cas.12366.

[34]. Ruhland MK, Coussens LM, Stewart SA. Senescence and cancer: an evolving inflammatory paradox. Biochim Biophys Acta. (2016) 1865:14–22. doi: 10.1016/j.bbcan.2015.10.001.

[35]. Coppé J-P, Desprez P-Y, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. (2010) 5:99–118. doi: 10.1146/annurev-pathol-121808-102144.

[36]. Kang T-W, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature. (2011) 479:547–51. doi: 10.1038/nature10599.

[37]. Brungs, D., Aghmesheh, M., Vine, K.L. et al. Gastric cancer stem cells: evidence, potential markers, and clinical implications. J Gastroenterol 51, 313–326 (2016). https://doi.org/10.1007/s00535-015-1125-5.

[38]. Singh, S. R. (2013). Gastric cancer stem cells: A novel therapeutic target. Cancer Letters, 338(1), 110–119. https://doi.org/10.1016/j.canlet.2013.03.035

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