Current situation and future of gene therapy for rare diseases

Research Article
Open access

Current situation and future of gene therapy for rare diseases

Gengqian Huang 1*
  • 1 Fujian Vocational College of Bio-engineering    
  • *corresponding author 3243791881@qq.com
Published on 20 December 2023 | https://doi.org/10.54254/2753-8818/21/20230904
TNS Vol.21
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-83558-215-2
ISBN (Online): 978-1-83558-216-9

Abstract

Rare genetic disorders are rare diseases that have a very low incidence, most of the patients are children, and most of them are caused by genetic defects. Many of these diseases are serious chronic genetic diseases with a small number of patients, low market demand, and high cost of drug research and development, so there is a lack of effective treatment methods, which often threaten life. Gene therapy is an emerging therapeutic approach that uses vectors to introduce genetic material into target cells to treat or prevent rare diseases by correcting or supplementing defective genes. This paper reviews the clinical application of gene therapy for rare diseases such as blood diseases, neurodegenerative diseases and eye diseases. At present, gene therapy still has some technical problems and rare diseases are complicated and cannot be effectively treated. In the future, with further research and overcoming these problems, the application of gene therapy in rare diseases will make continuous breakthroughs and bring good news to mankind.

Keywords:

gene therapy, rare diseases, gene editing, gene delivery.

Huang,G. (2023). Current situation and future of gene therapy for rare diseases. Theoretical and Natural Science,21,284-290.
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References

[1]. Richter T., Nestler-Parr S., Babela R., et al., Rare Disease Terminology and Definitions-A Systematic Global Review: Report of the ISPOR Rare Disease Special Interest Group [J]. Value Health, 18(6):906-914 (2015).

[2]. Yiting Gui, Qiang Li, Yonghao Gui, Application and prospect of gene therapy for rare diseases [J] Clin Pediatr, Vol.38, No.10, October, pp.794-798 (2020).

[3]. Yuhuan Li, Wei Li, Advances in Gene Therapy for Rare Diseases [J] Journal of Rare And Uncommon Diseases, March, Vol.30, No.3, Total No.164, pp.109-112 (2023).

[4]. Guoqing Liu, Yitong Xu, Xunde Xian, Chinese Journal of Medicinal Guide, Vol25, No 1, Total No.231, pp.9-12 (2023).

[5]. [5] Caihong He, Wanzi Jiang, Liwen Zhang, Meihua Ruan, Hongwen Zhou, Jianrong Yu, Current status and future perspectives of rare disease research, Hereditas (Beijing), June, 43(6): 531-544 (2021).

[6]. Atchison R.W., Casto B.C., Hammon W.M., Adenovirus-associated Defective Virus Particles [J]. Science, 149(3685):754-756 (1965).

[7]. Shi Tong, Jizong Li, Shanghai Center of Biomedicine Development, Journal of Pharmaceutical Practice, Vol. 40, No. 4, July 25, pp.296-313 (2022).

[8]. Foldvari M., Chen D. W., Nafissi N., et al. Non-viral gene therapy: gains and challenges of non-invasive administration methods [J]. J Control Release, 240: 165-190 (2016).

[9]. Haowei1 Min, Fei1 Wang, Zhaoyun Jiang, Fenglong Sun, et al., Gene therapy in the neighborhood of rare diseases: research advances [J] J Int Pharm Res, Vol.44, No.2, February (2017).

[10]. Ponder K.P., Hemophilia gene therapy: a Holy Grail found [J] Mol Ther, 19(3): 427-428 (2011).

[11]. Matrai J., Chuah M.K., VandenDriessche T., Preclinical and clinical progress in hemophilia gene therapy [J]. Curr Opin Hema⁃ tol, 17(5): 387-392 (2010).

[12]. Qiang Wang, Lin Zhang, Saijuan Chen, Gene therapy:current status and prospects,China Basic Science, (4), pp.21-27 (2017).

[13]. Leone P., Shera D., McPhee S.W., et al., Long-term follow-up after gene therapy for canavan disease [J]. Sci. Transl. Med., 4(165):165ra163 (2012).

[14]. Chien Y.H., Lee N.C., Tseng SH, et al., Efficacy and safety of AAV2 gene therapy in children with aromatic L-amino acid decarboxylase deficiency: an open-label, phase 1/2 trial [J]. The Lancet. Child & adolescent health, 1(4):265-273 (2017).

[15]. Rodrigues G.A., Shalaev E., Karami T.K., et al., Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye [J]. Pharm. Res., 36(2):29 (2018).

[16]. Bainbridge J.W., Smith A.J., Barker S.S., et al., Effect of gene therapy on visual function in Leber's congenital amaurosis [J]. N. Engl. J. Med., 358(21):2231-2239 (2008).

[17]. Maguire A.M., Simonelli F., Pierce E.A., et al., Safety and efficacy of gene transfer for Leber's congenital amaurosis [J]. N. Engl. J. Med., 358(21):2240-2248 (2008).

[18]. Naldini L., Medicine. A comeback for gene therapy [J]. Science, 326(5954):805-806 (2009).

[19]. Russell S., Bennett J., Wellman J.A., et al., Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial [J]. Lancet, 390(10097):849-860 (2017).

[20]. Bainbridge J.W., Mehat M.S., Sundaram V., et al., Long-term effect of gene therapy on Leber's congenital amaurosis [J]. N. Engl. J. Med., 372(20):1887-1897 (2015).

[21]. Jacobson S.G., Cideciyan A.V., Roman A.J., et al., Improvement and decline in vision with gene therapy in childhood blindness [J]. N. Engl. J. Med., 372(20):1920-1926 (2015).

[22]. Cideciyan A.V., Jacobson S.G., Beltran W.A., et al., Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement [J]. Proc. Natl. Acad. Sci. U. S. A., 110(6): E517-525 (2013).

[23]. Mendell J.R., Al-Zaidy S., Shell R., et al., Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy [J]. N. Engl. J. Med., 377(18):1713-1722 (2017).

[24]. Duan D., Systemic AAV Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy [J]. Mol. Ther., 26(10):2337-2356 (2018).

[25]. Qin X. F., An D. S., Chen S. Y., et al. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5 [J]. Proceedings of the National Academy of Sciences, 100(1): 183-188 (2003).


Cite this article

Huang,G. (2023). Current situation and future of gene therapy for rare diseases. Theoretical and Natural Science,21,284-290.

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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 3rd International Conference on Biological Engineering and Medical Science

ISBN:978-1-83558-215-2(Print) / 978-1-83558-216-9(Online)
Editor:Alan Wang
Conference website: https://www.icbiomed.org/
Conference date: 2 September 2023
Series: Theoretical and Natural Science
Volume number: Vol.21
ISSN:2753-8818(Print) / 2753-8826(Online)

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References

[1]. Richter T., Nestler-Parr S., Babela R., et al., Rare Disease Terminology and Definitions-A Systematic Global Review: Report of the ISPOR Rare Disease Special Interest Group [J]. Value Health, 18(6):906-914 (2015).

[2]. Yiting Gui, Qiang Li, Yonghao Gui, Application and prospect of gene therapy for rare diseases [J] Clin Pediatr, Vol.38, No.10, October, pp.794-798 (2020).

[3]. Yuhuan Li, Wei Li, Advances in Gene Therapy for Rare Diseases [J] Journal of Rare And Uncommon Diseases, March, Vol.30, No.3, Total No.164, pp.109-112 (2023).

[4]. Guoqing Liu, Yitong Xu, Xunde Xian, Chinese Journal of Medicinal Guide, Vol25, No 1, Total No.231, pp.9-12 (2023).

[5]. [5] Caihong He, Wanzi Jiang, Liwen Zhang, Meihua Ruan, Hongwen Zhou, Jianrong Yu, Current status and future perspectives of rare disease research, Hereditas (Beijing), June, 43(6): 531-544 (2021).

[6]. Atchison R.W., Casto B.C., Hammon W.M., Adenovirus-associated Defective Virus Particles [J]. Science, 149(3685):754-756 (1965).

[7]. Shi Tong, Jizong Li, Shanghai Center of Biomedicine Development, Journal of Pharmaceutical Practice, Vol. 40, No. 4, July 25, pp.296-313 (2022).

[8]. Foldvari M., Chen D. W., Nafissi N., et al. Non-viral gene therapy: gains and challenges of non-invasive administration methods [J]. J Control Release, 240: 165-190 (2016).

[9]. Haowei1 Min, Fei1 Wang, Zhaoyun Jiang, Fenglong Sun, et al., Gene therapy in the neighborhood of rare diseases: research advances [J] J Int Pharm Res, Vol.44, No.2, February (2017).

[10]. Ponder K.P., Hemophilia gene therapy: a Holy Grail found [J] Mol Ther, 19(3): 427-428 (2011).

[11]. Matrai J., Chuah M.K., VandenDriessche T., Preclinical and clinical progress in hemophilia gene therapy [J]. Curr Opin Hema⁃ tol, 17(5): 387-392 (2010).

[12]. Qiang Wang, Lin Zhang, Saijuan Chen, Gene therapy:current status and prospects,China Basic Science, (4), pp.21-27 (2017).

[13]. Leone P., Shera D., McPhee S.W., et al., Long-term follow-up after gene therapy for canavan disease [J]. Sci. Transl. Med., 4(165):165ra163 (2012).

[14]. Chien Y.H., Lee N.C., Tseng SH, et al., Efficacy and safety of AAV2 gene therapy in children with aromatic L-amino acid decarboxylase deficiency: an open-label, phase 1/2 trial [J]. The Lancet. Child & adolescent health, 1(4):265-273 (2017).

[15]. Rodrigues G.A., Shalaev E., Karami T.K., et al., Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye [J]. Pharm. Res., 36(2):29 (2018).

[16]. Bainbridge J.W., Smith A.J., Barker S.S., et al., Effect of gene therapy on visual function in Leber's congenital amaurosis [J]. N. Engl. J. Med., 358(21):2231-2239 (2008).

[17]. Maguire A.M., Simonelli F., Pierce E.A., et al., Safety and efficacy of gene transfer for Leber's congenital amaurosis [J]. N. Engl. J. Med., 358(21):2240-2248 (2008).

[18]. Naldini L., Medicine. A comeback for gene therapy [J]. Science, 326(5954):805-806 (2009).

[19]. Russell S., Bennett J., Wellman J.A., et al., Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial [J]. Lancet, 390(10097):849-860 (2017).

[20]. Bainbridge J.W., Mehat M.S., Sundaram V., et al., Long-term effect of gene therapy on Leber's congenital amaurosis [J]. N. Engl. J. Med., 372(20):1887-1897 (2015).

[21]. Jacobson S.G., Cideciyan A.V., Roman A.J., et al., Improvement and decline in vision with gene therapy in childhood blindness [J]. N. Engl. J. Med., 372(20):1920-1926 (2015).

[22]. Cideciyan A.V., Jacobson S.G., Beltran W.A., et al., Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement [J]. Proc. Natl. Acad. Sci. U. S. A., 110(6): E517-525 (2013).

[23]. Mendell J.R., Al-Zaidy S., Shell R., et al., Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy [J]. N. Engl. J. Med., 377(18):1713-1722 (2017).

[24]. Duan D., Systemic AAV Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy [J]. Mol. Ther., 26(10):2337-2356 (2018).

[25]. Qin X. F., An D. S., Chen S. Y., et al. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5 [J]. Proceedings of the National Academy of Sciences, 100(1): 183-188 (2003).