References
[1]. Shallis, R.M., et al. (2019) Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges. Blood reviews, 36: p. 70-87.
[2]. Bispo, J.A.B., P.S. Pinheiro, and E.K. Kobetz. (2020) Epidemiology and etiology of leukemia and lymphoma. Cold Spring Harbor perspectives in medicine, 10(6).
[3]. Chien, L.-N., et al. (2023) Epidemiology and survival outcomes of acute myeloid leukemia patients in Taiwan: A national population-based analysis from 2001 to 2015. Journal of the Formosan Medical Association, 122(6): p. 505-513.
[4]. Jaramillo, S. and R.F. Schlenk. (2023) Update on current treatments for adult acute myeloid leukemia: to treat acute myeloid leukemia intensively or non-intensively? That is the question. Haematologica, 108(2): p. 342-352.
[5]. Zhao, J.C., et al. (2022) A review of FLT3 inhibitors in acute myeloid leukemia. Blood reviews, 52: p. 100905.
[6]. Ishii, H. and S. Yano. (2022) New therapeutic strategies for adult acute myeloid leukemia. Cancers, 14(11): p. 2806.
[7]. Babakhanlou, R. and F. Ravandi-Kashani. (2023) Non-intensive acute myeloid leukemia therapies for older patients. Expert review of hematology, 16(3): p. 171-180.
[8]. Hanahan, D. (2022) Hallmarks of cancer: new dimensions. Cancer discovery, 12(1): p. 31-46.
[9]. Yang, L., et al. (2006) Acute myelogenous leukemia–derived SMAD4 mutations target the protein to ubiquitin‐proteasome degradation. Human mutation, 27(9): p. 897-905.
[10]. Imai, Y., et al. (2001) Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis. Oncogene, 20(1): p. 88-96.
[11]. McCarthy, A.J. and R. Chetty, Smad4/DPC4. (2018) Journal of clinical pathology, 71(8): p. 661-664.
[12]. Chang, H., et al.(2000) Smad5 is essential for left–right asymmetry in mice. Developmental biology, 219(1): p. 71-78.
[13]. Pakravan, K., et al.(2022) SMAD4 contributes to chondrocyte and osteocyte development. Journal of Cellular and Molecular Medicine, 26(1): p. 1-15.
[14]. Seyedi, Z., et al. (2023) Icariin: A promising natural product in biomedicine and tissue engineering. Journal of Functional Biomaterials, 14(1): p. 44.
[15]. Xia, S.-l., et al.(2023) Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1. Journal of Orthopaedic Surgery and Research, 18(1): p. 500.
[16]. Xie, D., et al.(2023) Icariin promotes osteogenic differentiation by upregulating alpha-enolase expression. Biochemistry and Biophysics Reports, 34: p. 101471.
[17]. Zhang, X., et al. (2018) Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis. International Journal of Oral Science, 10(2): p. 19.
[18]. Skopek, R., et al. (2023) Choosing the right cell line for acute myeloid leukemia (AML) research. International Journal of Molecular Sciences, 24(6): p. 5377.
Cite this article
Cao,Y. (2023). Icariin stimulates myeloid Leukemic cells differentiation by increasing smad4 protein abundance leading to the inhibition of myeloid Leukemic cell growth. Theoretical and Natural Science,24,25-32.
Data availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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References
[1]. Shallis, R.M., et al. (2019) Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges. Blood reviews, 36: p. 70-87.
[2]. Bispo, J.A.B., P.S. Pinheiro, and E.K. Kobetz. (2020) Epidemiology and etiology of leukemia and lymphoma. Cold Spring Harbor perspectives in medicine, 10(6).
[3]. Chien, L.-N., et al. (2023) Epidemiology and survival outcomes of acute myeloid leukemia patients in Taiwan: A national population-based analysis from 2001 to 2015. Journal of the Formosan Medical Association, 122(6): p. 505-513.
[4]. Jaramillo, S. and R.F. Schlenk. (2023) Update on current treatments for adult acute myeloid leukemia: to treat acute myeloid leukemia intensively or non-intensively? That is the question. Haematologica, 108(2): p. 342-352.
[5]. Zhao, J.C., et al. (2022) A review of FLT3 inhibitors in acute myeloid leukemia. Blood reviews, 52: p. 100905.
[6]. Ishii, H. and S. Yano. (2022) New therapeutic strategies for adult acute myeloid leukemia. Cancers, 14(11): p. 2806.
[7]. Babakhanlou, R. and F. Ravandi-Kashani. (2023) Non-intensive acute myeloid leukemia therapies for older patients. Expert review of hematology, 16(3): p. 171-180.
[8]. Hanahan, D. (2022) Hallmarks of cancer: new dimensions. Cancer discovery, 12(1): p. 31-46.
[9]. Yang, L., et al. (2006) Acute myelogenous leukemia–derived SMAD4 mutations target the protein to ubiquitin‐proteasome degradation. Human mutation, 27(9): p. 897-905.
[10]. Imai, Y., et al. (2001) Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis. Oncogene, 20(1): p. 88-96.
[11]. McCarthy, A.J. and R. Chetty, Smad4/DPC4. (2018) Journal of clinical pathology, 71(8): p. 661-664.
[12]. Chang, H., et al.(2000) Smad5 is essential for left–right asymmetry in mice. Developmental biology, 219(1): p. 71-78.
[13]. Pakravan, K., et al.(2022) SMAD4 contributes to chondrocyte and osteocyte development. Journal of Cellular and Molecular Medicine, 26(1): p. 1-15.
[14]. Seyedi, Z., et al. (2023) Icariin: A promising natural product in biomedicine and tissue engineering. Journal of Functional Biomaterials, 14(1): p. 44.
[15]. Xia, S.-l., et al.(2023) Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1. Journal of Orthopaedic Surgery and Research, 18(1): p. 500.
[16]. Xie, D., et al.(2023) Icariin promotes osteogenic differentiation by upregulating alpha-enolase expression. Biochemistry and Biophysics Reports, 34: p. 101471.
[17]. Zhang, X., et al. (2018) Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis. International Journal of Oral Science, 10(2): p. 19.
[18]. Skopek, R., et al. (2023) Choosing the right cell line for acute myeloid leukemia (AML) research. International Journal of Molecular Sciences, 24(6): p. 5377.