The use of 3D printing and growth factor in cosmetics medicine

Research Article
Open access

The use of 3D printing and growth factor in cosmetics medicine

Zeyu Qi 1* , Huaiyue Zhang 2
  • 1 Ronghuai Elite High School    
  • 2 Haileybury    
  • *corresponding author bdghsb22@gmail.com
Published on 20 December 2023 | https://doi.org/10.54254/2753-8818/24/20231116
TNS Vol.24
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-83558-221-3
ISBN (Online): 978-1-83558-222-0

Abstract

The equipment we have designed consists of two main parts: the outer part and the inner part. The outer part features a 3D printed nose bridge made from Polylactic acid (PLA) and collagen. This combination of materials serves a dual purpose: the PLA aids in replacing dead skin cells and supports blood clotting, which facilitates faster post-operative recovery. Meanwhile, the inner part is filled with autologous fat infused with connective tissue growth factor. This choice is grounded in the fact that cartilage, a key component in this context, belongs to the connective tissue category. Under optimal conditions, this innovative equipment demonstrates promising efficacy.

Keywords:

Polylactic acid (PLA), autologous fat, connective tissue growth factor, augmentation rhinoplasty

Qi,Z.;Zhang,H. (2023). The use of 3D printing and growth factor in cosmetics medicine. Theoretical and Natural Science,24,236-245.
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References

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[15]. Sionkowska, A., Adamiak, K., Musiał, K., & Gadomska, M. (2020). Collagen based materials in cosmetic applications: a review. Materials, 13(19), 4217. https://doi.org/10.3390/ma13194217

[16]. Baylink, D. J., Finkelman, R. D., & Mohan, S. (2009). Growth factors to stimulate bone formation. Journal of Bone and Mineral Research, 8(S2), S565–S572. https://doi.org/10.1002/jbmr.5650081326

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[20]. Lafky, J. M., Wilken, J. A., Baron, A. T., & Maihle, N. J. (2008). Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer. Biochimica Et Biophysica Acta - Reviews on Cancer, 1785(2), 232–265. https://doi.org/10.1016/j.bbcan.2008.01.001

[21]. Smallwood, P. M., Munoz-Sanjuan, I., Tong, P. C., Macke, J. P., Hendry, S. H. C., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1996). Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proceedings of the National Academy of Sciences of the United States of America, 93(18), 9850–9857. https://doi.org/10.1073/pnas.93.18.9850

[22]. FGF signaling in the Diseased Nervous System https://link.springer.com/article/10.1007/s12035-021-02367-0

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[25]. Urist, M. R. (1965). Bone: formation by autoinduction. Science, 150(3698), 893–899. https://doi.org/10.1126/science.150.3698.893

[26]. Jones, C. M., Lyons, K. M., Lapan, P. M., Wright, C., & Hogan, B. L. (1992). DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development, 115(2), 639–647. https://doi.org/10.1242/dev.115.2.639

[27]. Sykaras, N., & Opperman, L. A. (2003). Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician? Journal of Oral Science, 45(2), 57–73. https://doi.org/10.2334/josnusd.45.57

[28]. Ross, R., Raines, E. W., & Bowen-Pope, D. F. (1986). The biology of platelet-derived growth factor. Cell, 46(2), 155–169. https://doi.org/10.1016/0092-8674(86)90733-6

[29]. Chesebro, J. H., & Fuster, V. (1986). Platelet-Inhibitor Drugs before and after Coronary Artery Bypass Surgery and Coronary Angioplasty: The Basis of Their Use, Data from Animal Studies, Clinical Trial Data, and Current Recommendations. Cardiology, 73(4–5), 292–305. https://doi.org/10.1159/000174022

[30]. Habenicht, A. J. R., Glomset, J. A., King, W. C., Nist, C., Mitchell, C. D., & Ross, R. (1981). Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor. Journal of Biological Chemistry, 256(23), 12329–12335. https://doi.org/10.1016/s0021-9258(18)43275-9

[31]. Gospodarowicz, D., Abraham, J. A., & Schilling, J. (1989). Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proceedings of the National Academy of Sciences of the United States of America, 86(19), 7311–7315. https://doi.org/10.1073/pnas.86.19.7311

[32]. Neufeld, G., Cohen, T., Gengrinovitch, S., & Poltorak, Z. (1999). Vascular endothelial growth factor (VEGF) and its receptors. The FASEB Journal, 13(1), 9–22. https://doi.org/10.1096/fasebj.13.1.9

[33]. Moussad, E. E. A., & Brigstock, D. R. (2000). Connective tissue growth factor: What’s in a name? Molecular Genetics and Metabolism, 71(1–2), 276–292. https://doi.org/10.1006/mgme.2000.3059

[34]. Zhu, W., & Dong, C. (2022). Poly‐L‐Lactic acid increases collagen gene expression and synthesis in cultured dermal fibroblast (Hs68) through the TGF‐β/Smad pathway. Journal of Cosmetic Dermatology. https://doi.org/10.1111/jocd.15571

[35]. Karadağ, D., Ozdol, N., Beriat, K., & Akıncı, T. (2011). CT evaluation of the bony nasal pyramid dimensions in Anatolian people. Dentomaxillofacial Radiology, 40(3), 160–164. https://doi.org/10.1259/dmfr/35578628

[36]. Bucky, L. P., & Kanchwala, S. (2007c). The role of autologous fat and alternative fillers in the aging face. Plastic and Reconstructive Surgery, 120(Supplement), 89S-97S. https://doi.org/10.1097/01.prs.0000248866.57638.40

[37]. Nishida, T., Kubota, S., Kojima, S., Kuboki, T., Nakao, K., Kubota, T., Tabata, Y., & Takigawa, M. (2004c). Regeneration of defects in articular cartilage in rat knee joints by CCN2 (Connective Tissue Growth Factor). Journal of Bone and Mineral Research, 19(8), 1308–1319. https://doi.org/10.1359/jbmr.040322


Cite this article

Qi,Z.;Zhang,H. (2023). The use of 3D printing and growth factor in cosmetics medicine. Theoretical and Natural Science,24,236-245.

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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About volume

Volume title: Proceedings of the 3rd International Conference on Biological Engineering and Medical Science

ISBN:978-1-83558-221-3(Print) / 978-1-83558-222-0(Online)
Editor:Alan Wang
Conference website: https://www.icbiomed.org/
Conference date: 2 September 2023
Series: Theoretical and Natural Science
Volume number: Vol.24
ISSN:2753-8818(Print) / 2753-8826(Online)

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References

[1]. Carmel. (2019). 3D printing technologies and techniques. Sculpteo. https://www.sculpteo.com/en/3d-printing/3d-printing-technologies/

[2]. 3Dsourced. (2023.July.17). The complete history of 3D printing: From 1980 to 2023 - 3DSourced. 3DSourced. https://www.3dsourced.com/guides/history-of-3d-printing/

[3]. Catarino, S. O., Lima, R., & Minas, G. (2017). Smart devices. In Elsevier eBooks (pp. 331–369). https://doi.org/10.1016/b978-0-08-100741-9.00012-7

[4]. Ceramics - Research. Robert K. Prud’Homme. Ilhan A. Aksay(2001). https://www.princeton.edu/ ~cml/html/research/stereolithography.html

[5]. Prototech Asia. (2019, July 2). Advantages and limitations of 3D printing by Stereolitography. https://prototechasia.com/en/stereolithography/advantages

[6]. Dalle-Ferrier, C Kisliuk A. Hong L. Carini G. D’Angelo G. Alba-Simionesco C. Novikov V. N. & Sokolov A. P. (2016). Why many polymers are so fragile: A new perspective. Journal of Chemical Physics, 145(15), 154901. https://doi.org/10.1063/1.4964362>

[7]. Dizon, J. R. C., Espera, A. H., Chen, Q., & Advincula, R. C. (2017.Dec). Mechanical characterization of 3D-printed polymers. Additive Manufacturing, 20, 44–67. https://doi.org/10.1016/j.addma.2017.12.002

[8]. Thorat, S. (2020, February 22). Selective laser sintering - Advantages and disadvantages. Learn Mechanical Engineering. https://learnmech.com/selective-laser-sintering-advantages-and-disadvantages/

[9]. How does selective laser sintering (SLS) work? (2020.). NETZSCH - Analyzing and Testing. Leading in Thermal Analysis, Rheology and Fire Testing. https://analyzing-testing.netzsch.com/en/blog/2020/how-does-selective-laser-sintering-sls-work

[10]. Cano-Vicent, A., Tambuwala, M. M., Hassan, S. S., Barh, D., Aljabali, A. a. A., Birkett, M., Arjunan, A., & Serrano-Aroca, Á. (2021). Fused deposition modelling: Current status, methodology, applications and future prospects. Science Direct, 47, 102378. https://doi.org/10.1016/j.addma.2021.102378

[11]. https://www.fastradius.com/resources/fused-deposition-modeling-advantages-and-disadvantages/#:~:text=Fused deposition modeling advantages and disadvantages 1 Advantages,your ideas to life with Fast Radius

[12]. Prototype, V. R. (2023). Fused Deposition Modeling: How Does it Work? V1prototype. https://www.v1prototype.com/fused-deposition-modeling-how-does-it-work/

[13]. Paul, P. E. V., Sangeetha, V., & Deepika, R. G. (2019). Emerging trends in the industrial production of chemical products by microorganisms. In Elsevier eBooks (pp. 107–125). https://doi.org/10.1016/b978-0-12-816328-3.00009-x

[14]. Chen, T. (2011). Compound yarns. In Elsevier eBooks (pp. 1–20). https://doi.org/10.1533/9780857093936.1

[15]. Sionkowska, A., Adamiak, K., Musiał, K., & Gadomska, M. (2020). Collagen based materials in cosmetic applications: a review. Materials, 13(19), 4217. https://doi.org/10.3390/ma13194217

[16]. Baylink, D. J., Finkelman, R. D., & Mohan, S. (2009). Growth factors to stimulate bone formation. Journal of Bone and Mineral Research, 8(S2), S565–S572. https://doi.org/10.1002/jbmr.5650081326

[17]. Wergedal, J. E., Mohan, S., Lundy, M. W., & Baylink, D. J. (1990). Skeletal growth factor and other growth factors known to be present in bone matrix stimulate proliferation and protein synthesis in human bone cells. Journal of Bone and Mineral Research, 5(2), 179–186. https://doi.org/10.1002/jbmr.5650050212

[18]. WebMD Editorial Contributors. (2020, November 3). Health benefits of collagen. WebMD. https://www.webmd.com/diet/collagen-health-benefits

[19]. Barrientos, S., Stojadinovic, O., Golinko, M., Brem, H., & Tomic-Canic, M. (2008). PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing. Wound Repair and Regeneration, 16(5), 585–601. https://doi.org/10.1111/j.1524-475x.2008.00410.x

[20]. Lafky, J. M., Wilken, J. A., Baron, A. T., & Maihle, N. J. (2008). Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer. Biochimica Et Biophysica Acta - Reviews on Cancer, 1785(2), 232–265. https://doi.org/10.1016/j.bbcan.2008.01.001

[21]. Smallwood, P. M., Munoz-Sanjuan, I., Tong, P. C., Macke, J. P., Hendry, S. H. C., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1996). Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proceedings of the National Academy of Sciences of the United States of America, 93(18), 9850–9857. https://doi.org/10.1073/pnas.93.18.9850

[22]. FGF signaling in the Diseased Nervous System https://link.springer.com/article/10.1007/s12035-021-02367-0

[23]. Massagué, J. (1990). The transforming growth factor-Beta family. Annual Review of Cell Biology, 6(1), 597–641. https://doi.org/10.1146/annurev.cb.06.110190.003121

[24]. “Bone Morphogenetic Proteins (BMPs) belong to the TGF-Β superfamily, did you know? (2021, January 13). Lianke Biotechnology. http://www.liankebio.com/article-information_Dynamic-3093.html”

[25]. Urist, M. R. (1965). Bone: formation by autoinduction. Science, 150(3698), 893–899. https://doi.org/10.1126/science.150.3698.893

[26]. Jones, C. M., Lyons, K. M., Lapan, P. M., Wright, C., & Hogan, B. L. (1992). DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development, 115(2), 639–647. https://doi.org/10.1242/dev.115.2.639

[27]. Sykaras, N., & Opperman, L. A. (2003). Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician? Journal of Oral Science, 45(2), 57–73. https://doi.org/10.2334/josnusd.45.57

[28]. Ross, R., Raines, E. W., & Bowen-Pope, D. F. (1986). The biology of platelet-derived growth factor. Cell, 46(2), 155–169. https://doi.org/10.1016/0092-8674(86)90733-6

[29]. Chesebro, J. H., & Fuster, V. (1986). Platelet-Inhibitor Drugs before and after Coronary Artery Bypass Surgery and Coronary Angioplasty: The Basis of Their Use, Data from Animal Studies, Clinical Trial Data, and Current Recommendations. Cardiology, 73(4–5), 292–305. https://doi.org/10.1159/000174022

[30]. Habenicht, A. J. R., Glomset, J. A., King, W. C., Nist, C., Mitchell, C. D., & Ross, R. (1981). Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor. Journal of Biological Chemistry, 256(23), 12329–12335. https://doi.org/10.1016/s0021-9258(18)43275-9

[31]. Gospodarowicz, D., Abraham, J. A., & Schilling, J. (1989). Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proceedings of the National Academy of Sciences of the United States of America, 86(19), 7311–7315. https://doi.org/10.1073/pnas.86.19.7311

[32]. Neufeld, G., Cohen, T., Gengrinovitch, S., & Poltorak, Z. (1999). Vascular endothelial growth factor (VEGF) and its receptors. The FASEB Journal, 13(1), 9–22. https://doi.org/10.1096/fasebj.13.1.9

[33]. Moussad, E. E. A., & Brigstock, D. R. (2000). Connective tissue growth factor: What’s in a name? Molecular Genetics and Metabolism, 71(1–2), 276–292. https://doi.org/10.1006/mgme.2000.3059

[34]. Zhu, W., & Dong, C. (2022). Poly‐L‐Lactic acid increases collagen gene expression and synthesis in cultured dermal fibroblast (Hs68) through the TGF‐β/Smad pathway. Journal of Cosmetic Dermatology. https://doi.org/10.1111/jocd.15571

[35]. Karadağ, D., Ozdol, N., Beriat, K., & Akıncı, T. (2011). CT evaluation of the bony nasal pyramid dimensions in Anatolian people. Dentomaxillofacial Radiology, 40(3), 160–164. https://doi.org/10.1259/dmfr/35578628

[36]. Bucky, L. P., & Kanchwala, S. (2007c). The role of autologous fat and alternative fillers in the aging face. Plastic and Reconstructive Surgery, 120(Supplement), 89S-97S. https://doi.org/10.1097/01.prs.0000248866.57638.40

[37]. Nishida, T., Kubota, S., Kojima, S., Kuboki, T., Nakao, K., Kubota, T., Tabata, Y., & Takigawa, M. (2004c). Regeneration of defects in articular cartilage in rat knee joints by CCN2 (Connective Tissue Growth Factor). Journal of Bone and Mineral Research, 19(8), 1308–1319. https://doi.org/10.1359/jbmr.040322