Research on the rabies and rabies vaccines

Research Article
Open access

Research on the rabies and rabies vaccines

Xinyao Wu 1*
  • 1 Central South University of Forestry and Technology    
  • *corresponding author 20200409@csuft.edu.cn
Published on 20 December 2023 | https://doi.org/10.54254/2753-8818/24/20231142
TNS Vol.24
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-83558-221-3
ISBN (Online): 978-1-83558-222-0

Abstract

Rabies is a highly lethal disease with a long history that most of the patients were infected by dog bites. Therefore, the scientific popularization and research of rabies are particularly important. This article mainly analyzes rabies from three aspects: the rabies virus, the rabies vaccines and treatment methods. Firstly, the infection mode and characteristics of the rabies virus and some clinical features after human infection with the rabies virus were analyzed, so as to facilitate people's understanding of the infection route and reduce the infection rate. The introduction of clinical features also made it easier for doctors or relatives of patients to determine whether patients were infected with rabies. Enable patients to get effective treatment quickly. The rabies vaccine is the main measure to prevent rabies. This part lists the history of human rabies vaccines and introduces some successful human rabies vaccines. Finally, the current treatment status of rabies is introduced, the methods that may play an important role in the treatment of rabies in the future are proposed, and the possibility of rabies being cured is confirmed. However, due to the complex mechanism of rabies itself, it is still necessary to continue to study rabies in order to completely defeat this disease.

Keywords:

rabies, virus, vaccine, treatment, clinical feature

Wu,X. (2023). Research on the rabies and rabies vaccines. Theoretical and Natural Science,24,146-150.
Export citation

References

[1]. Tarantola, A., Four thousand years of concepts relating to rabies in animals and humans, its prevention and its cure. Tropical medicine and infectious disease, 2017. 2(2): p. 5.

[2]. Jiaxi, C., Research Progress of Vaccines and Diagnosis TreatmentMethod in Rabies. 2023-07-20.

[3]. Banyard, A. and N. Tordo, Rabies pathogenesis and immunology. Revue scientifique et technique (International Office of Epizootics), 2018. 37(2): p. 323-330.

[4]. Nigg, A.J. and P.L. Walker, Overview, prevention, and treatment of rabies. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2009. 29(10): p. 1182-1195.

[5]. Willoughby, R.E., A cure for rabies? Scientific American, 2007. 296(4): p. 88-95.

[6]. Mitrabhakdi, E., et al., Difference in neuropathogenetic mechanisms in human furious and paralytic rabies. Journal of the neurological sciences, 2005. 238(1-2): p. 3-10.

[7]. Hemachudha, T., et al., Human rabies: neuropathogenesis, diagnosis, and management. The Lancet Neurology, 2013. 12(5): p. 498-513.

[8]. Warrell, D. and M. Warrell, Human rabies and its prevention: an overview. Reviews of infectious diseases, 1988. 10(Supplement_4): p. S726-S731.

[9]. Jiaxin, Y., Can Rabies Be Cured. Scientific American, 2012-5-17.

[10]. McGettigan, J.P., Experimental rabies vaccines for humans. Expert review of vaccines, 2010. 9(10): p. 1177-1186.

[11]. Wu, X., T.G. Smith, and C.E. Rupprecht, From brain passage to cell adaptation: the road of human rabies vaccine development. Expert review of vaccines, 2011. 10(11): p. 1597-1608.

[12]. Fermi, C., Über die immunisierung gegen wutkrankheit. Zeitschrift für Hygiene und Infektionskrankheiten, 1908. 58(1): p. 233-276.

[13]. Kissling, R., Growth of rabies virus in non-nervous tissue culture. Proceedings of the society for experimental biology and medicine, 1958. 98(2): p. 223-225.

[14]. Hooper, D.C., et al., Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system. Journal of virology, 1998. 72(5): p. 3711-3719.

[15]. Hicks, D., A. Fooks, and N. Johnson, Developments in rabies vaccines. Clinical & Experimental Immunology, 2012. 169(3): p. 199-204.

[16]. Huang, C.T., et al., Enhancement of blood–brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice. Antiviral Research, 2014. 110: p. 132-141.

[17]. Shimao, Z. and G. Caiping, Rabies Control and Treatment: From Prophylaxis to Strategies with Curative Potential. Viruses, 2016. 8(11).

[18]. Li, J., et al., Single domain antibody-based bispecific antibody induces potent specific anti-tumor activity. Cancer Biology & Therapy, 2016: p. 00-00.

[19]. Conceição, P. and C. Abreu, Human rabies: optimization of prevention and paths towards the cure. Acta Medica Portuguesa, vol. 34 (11), p. 767-773, 2020.


Cite this article

Wu,X. (2023). Research on the rabies and rabies vaccines. Theoretical and Natural Science,24,146-150.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

Disclaimer/Publisher's Note

The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of EWA Publishing and/or the editor(s). EWA Publishing and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

About volume

Volume title: Proceedings of the 3rd International Conference on Biological Engineering and Medical Science

ISBN:978-1-83558-221-3(Print) / 978-1-83558-222-0(Online)
Editor:Alan Wang
Conference website: https://www.icbiomed.org/
Conference date: 2 September 2023
Series: Theoretical and Natural Science
Volume number: Vol.24
ISSN:2753-8818(Print) / 2753-8826(Online)

© 2024 by the author(s). Licensee EWA Publishing, Oxford, UK. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. Authors who publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open access policy for details).

References

[1]. Tarantola, A., Four thousand years of concepts relating to rabies in animals and humans, its prevention and its cure. Tropical medicine and infectious disease, 2017. 2(2): p. 5.

[2]. Jiaxi, C., Research Progress of Vaccines and Diagnosis TreatmentMethod in Rabies. 2023-07-20.

[3]. Banyard, A. and N. Tordo, Rabies pathogenesis and immunology. Revue scientifique et technique (International Office of Epizootics), 2018. 37(2): p. 323-330.

[4]. Nigg, A.J. and P.L. Walker, Overview, prevention, and treatment of rabies. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2009. 29(10): p. 1182-1195.

[5]. Willoughby, R.E., A cure for rabies? Scientific American, 2007. 296(4): p. 88-95.

[6]. Mitrabhakdi, E., et al., Difference in neuropathogenetic mechanisms in human furious and paralytic rabies. Journal of the neurological sciences, 2005. 238(1-2): p. 3-10.

[7]. Hemachudha, T., et al., Human rabies: neuropathogenesis, diagnosis, and management. The Lancet Neurology, 2013. 12(5): p. 498-513.

[8]. Warrell, D. and M. Warrell, Human rabies and its prevention: an overview. Reviews of infectious diseases, 1988. 10(Supplement_4): p. S726-S731.

[9]. Jiaxin, Y., Can Rabies Be Cured. Scientific American, 2012-5-17.

[10]. McGettigan, J.P., Experimental rabies vaccines for humans. Expert review of vaccines, 2010. 9(10): p. 1177-1186.

[11]. Wu, X., T.G. Smith, and C.E. Rupprecht, From brain passage to cell adaptation: the road of human rabies vaccine development. Expert review of vaccines, 2011. 10(11): p. 1597-1608.

[12]. Fermi, C., Über die immunisierung gegen wutkrankheit. Zeitschrift für Hygiene und Infektionskrankheiten, 1908. 58(1): p. 233-276.

[13]. Kissling, R., Growth of rabies virus in non-nervous tissue culture. Proceedings of the society for experimental biology and medicine, 1958. 98(2): p. 223-225.

[14]. Hooper, D.C., et al., Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system. Journal of virology, 1998. 72(5): p. 3711-3719.

[15]. Hicks, D., A. Fooks, and N. Johnson, Developments in rabies vaccines. Clinical & Experimental Immunology, 2012. 169(3): p. 199-204.

[16]. Huang, C.T., et al., Enhancement of blood–brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice. Antiviral Research, 2014. 110: p. 132-141.

[17]. Shimao, Z. and G. Caiping, Rabies Control and Treatment: From Prophylaxis to Strategies with Curative Potential. Viruses, 2016. 8(11).

[18]. Li, J., et al., Single domain antibody-based bispecific antibody induces potent specific anti-tumor activity. Cancer Biology & Therapy, 2016: p. 00-00.

[19]. Conceição, P. and C. Abreu, Human rabies: optimization of prevention and paths towards the cure. Acta Medica Portuguesa, vol. 34 (11), p. 767-773, 2020.