Relationship Between Amyloid-beta Deposition and Tau Deposition in Alzheimer's Disease

Research Article
Open access

Relationship Between Amyloid-beta Deposition and Tau Deposition in Alzheimer's Disease

Siying Li 1*
  • 1 High School Attached to Northeast Normal University, Changchun, 130017, China    
  • *corresponding author Ainsley1225@163.com
Published on 20 June 2025 | https://doi.org/10.54254/2753-8818/2025.24200
TNS Vol.116
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-80590-197-6
ISBN (Online): 978-1-80590-198-3

Abstract

So far, the primary culprits in the onset of Alzheimer's disease are the deposits of amyloid-β (Aβ) proteins and the formation of tau protein knots. These markers are crucial for a conclusive pathological diagnosis. Despite the significance of both amyloid-β deposits and tau protein knots, the nature of their interaction remains largely unexplained, and the scientific inquiries into this relationship yield a patchy and inconclusive body of research. In this paper, we find out Aβ plaques accelerate neurotic plaque tau aggregation and propagation and apply fluorescent biotechnique to detect and measure Aβ oligomers in normal and tau seed condition. The findings indicate that upon introducing varied concentrations of Aβ aggregates into culture mediums devoid of lipofectamine, both Aβ filaments and newly synthesized Aβ enhance tau nucleation in correlation with their concentration. Moreover, Aβ oligomers exhibit a more pronounced stimulatory effect, strongly suggesting an interaction between Aβ and tau.

Keywords:

amyloid-β (Aβ) protein, tau protein, Alzheimer's disease (AD), interaction

Li,S. (2025). Relationship Between Amyloid-beta Deposition and Tau Deposition in Alzheimer's Disease. Theoretical and Natural Science,116,8-12.
Export citation

References

[1]. Zhang, H., Wei, W., Zhao, M., Ma, L., Jiang, X., Pei, H., Cao, Y., Li, H. (2021). Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease. International Journal of Biological Sciences, 17(9), 2181-2192. https://doi.org/10.7150/ijbs

[2]. Rodriguez-Vieitez, E., Montal, V., Sepulcre, J. et al. Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Mol Psychiatry 26, 7813–7822 (2021). https://doi.org/10.1038/s41380-021-01290-z

[3]. Shin, W.S., Di, J., Cao, Q. et al. Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alz Res Therapy 11, 86 (2019). https://doi.org/10.1186/s13195-019-0541-9

[4]. Cai, Y., Du, J., Li, A. et al. Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer’s disease. Alz Res Therapy 15, 30 (2023). https://doi.org/10.1186/s13195-023-01178-w

[5]. Wang C, Holtzman DM. Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors. Neuropsychopharmacology. 2020 Jan;45(1):104-120.

[6]. Karran E, De Strooper B. The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics. Nat Rev Drug Discov. 2022 Apr;21(4):306-318

[7]. Chen Y, Yu Y. Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation. J Neuroinflammation. 2023 Jul 14;20(1):165.

[8]. Doré V, Krishnadas N, Bourgeat P, Huang K, Li S, Burnham S, Masters CL, Fripp J, Villemagne VL, Rowe CC. Relationship between amyloid and tau levels and its impact on tau spreading. Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2225-2232.

[9]. Zhao Y, Liu B, Wang J, Xu L, Yu S, Fu J, Yan X, Su J. Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer's Disease. Biomedicines. 2022 Jul 27;10(8):1800.

[10]. Int. J. Mol. Sci. 2020, 21(12), 4477; https://doi.org/10.3390/ijms21124477

Cite this article

Li,S. (2025). Relationship Between Amyloid-beta Deposition and Tau Deposition in Alzheimer's Disease. Theoretical and Natural Science,116,8-12.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

Disclaimer/Publisher's Note

The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of EWA Publishing and/or the editor(s). EWA Publishing and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

About volume

Volume title: Proceedings of the 3rd International Conference on Modern Medicine and Global Health

ISBN：978-1-80590-197-6(Print) / 978-1-80590-198-3(Online)
Editor：Sheiladevi Sukumaran
Conference website: https://2025.icmmgh.org/
Conference date: 20 January 2025
Series: Theoretical and Natural Science
Volume number: Vol.116
ISSN：2753-8818(Print) / 2753-8826(Online)

© 2024 by the author(s). Licensee EWA Publishing, Oxford, UK. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. Authors who publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open access policy for details).

References

[1]. Zhang, H., Wei, W., Zhao, M., Ma, L., Jiang, X., Pei, H., Cao, Y., Li, H. (2021). Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease. International Journal of Biological Sciences, 17(9), 2181-2192. https://doi.org/10.7150/ijbs

[2]. Rodriguez-Vieitez, E., Montal, V., Sepulcre, J. et al. Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Mol Psychiatry 26, 7813–7822 (2021). https://doi.org/10.1038/s41380-021-01290-z

[3]. Shin, W.S., Di, J., Cao, Q. et al. Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alz Res Therapy 11, 86 (2019). https://doi.org/10.1186/s13195-019-0541-9

[4]. Cai, Y., Du, J., Li, A. et al. Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer’s disease. Alz Res Therapy 15, 30 (2023). https://doi.org/10.1186/s13195-023-01178-w

[5]. Wang C, Holtzman DM. Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors. Neuropsychopharmacology. 2020 Jan;45(1):104-120.

[6]. Karran E, De Strooper B. The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics. Nat Rev Drug Discov. 2022 Apr;21(4):306-318

[7]. Chen Y, Yu Y. Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation. J Neuroinflammation. 2023 Jul 14;20(1):165.

[8]. Doré V, Krishnadas N, Bourgeat P, Huang K, Li S, Burnham S, Masters CL, Fripp J, Villemagne VL, Rowe CC. Relationship between amyloid and tau levels and its impact on tau spreading. Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2225-2232.

[9]. Zhao Y, Liu B, Wang J, Xu L, Yu S, Fu J, Yan X, Su J. Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer's Disease. Biomedicines. 2022 Jul 27;10(8):1800.

[10]. Int. J. Mol. Sci. 2020, 21(12), 4477; https://doi.org/10.3390/ijms21124477

For authors
Guide for authors Policies for authors Aims and scope Subscription Open access policy
For editors
Policies for editors Editorial board
For reviewers
Policies for reviewers Privacy policy

Cookies are used by this site.
Copyright © 2024 EWA Publishing, its licensors, and contributors. All rights reserved, including text and data mining, AI training, and similar technologies.