References
[1]. The Pharmaceutical Journal. (2017) A brief history of ibuprofen. https://pharmaceutical-journal.com/article/infographics/a-brief-history-of-ibuprofen
[2]. Marshall, S. F., Bernstein, L., Anton-Culver, H., Deapen, D., Horn-Ross, P. L., Mohrenweiser, H., Peel, D., Pinder, R., Purdie, D. M., Reynolds, P., Stram, D., West, D., Wright, W. E., Ziogas, A., & Ross, R. K. (2005). Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status. Journal of the National Cancer Institute., 97: 805–812.
[3]. Chen H, Jacobs E, Schwarzschild M et al. (2005) Nonsteroidal antiinflammatory drug use and the risk for Parkinson’s disease. Ann Neurol ;58:963–967.
[4]. Vlad, S. C., Miller, D. R., Kowall, N. W., & Felson, D. T. (2008) Protective effects of NSAIDs on the development of Alzheimer disease. Neurology., 70: 1672–1677.
[5]. Sondergaard, K. B., Weeke, P., Wissenberg, M., Olsen, A. S., Fosbol, E. L., Lippert, F. K., Torp-Pedersen, C., Gislason, G. H., & Folke, F. (2016) Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case-time-control study. European Heart Journal-Cardiovascular Pharmacotherapy., 356:100–107.
[6]. DrugBank Online. Ibuprofen: Uses, interactions, mechanism of action. https://go.drugbank.com/drugs/DB01050
[7]. Zeng, Y., Wang, Y., Liang, Z., & Jiao, Z. (2020) The study of chiral recognition on ibuprofen enantiomers by a fluorescent probe based on β-cyclodextrin modified ZnS: Mn quantum dots. https://doi.org/10.1016/j.saa.2020.119002
[8]. Ricciotti, E, & FitzGerald, G. A. (2011) Prostaglandins and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology., 31: 986–1000.
[9]. Encyclopedia Britannica. (2024) Prostaglandin | Definition, Function, Synthesis, & Facts. https://www.britannica.com/science/prostaglandin
[10]. Mediators of Inflammation. (2012) PGI2 as a regulator of inflammatory diseases. https://pubmed.ncbi.nlm.nih.gov/22851816/
[11]. BMC Veterinary Research. (2019). Prostaglandin F2α (PGF2α) production possibility and its receptors expression in the early- and late cleavedpreimplantation bovine embryos. https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-019-1939-0
[12]. Wang, J, Liu, M, Zhang, X, Yang, G, & Chen, L.(2018) Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney. Prostaglandins & Other Lipid Mediators., 134: 1- 6.
[13]. PubMed. (2024) Physiology, Thromboxane A2. https://pubmed.ncbi.nlm.nih.gov/30969639/
[14]. Mediators of Inflammation. (2012) PGD synthase and PGD2 in immune response. https://doi.org/10.1155/2012/503128
[15]. Karim, S. M. M., Sandler, M., & Williams, E. D. (1967) Distribution of prostaglandins in human tissues. British Journal of Pharmacology and Chemotherapy., 31: 340–344
[16]. Blobaum, A. L., & Marnett, L. J. (2007) Structural and functional basis of cyclooxygenase inhibition. Journal of Medicinal Chemistry., 50: 1425–1441.
[17]. Mazaleuskaya, L. L., Theken, K. N., Gong, L., Thorn, C. F., FitzGerald, G. A., Altman, R. B., & Klein, T. E. (2014) PharmGKB summary. Pharmacogenetics and Genomics., 23: 96–106.
Cite this article
Jiang,Z.;Liu,Z. (2025). Comprehensive Overview: The History, Structure, Composition, and Mechanism of Ibuprofen. Theoretical and Natural Science,115,137-142.
Data availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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References
[1]. The Pharmaceutical Journal. (2017) A brief history of ibuprofen. https://pharmaceutical-journal.com/article/infographics/a-brief-history-of-ibuprofen
[2]. Marshall, S. F., Bernstein, L., Anton-Culver, H., Deapen, D., Horn-Ross, P. L., Mohrenweiser, H., Peel, D., Pinder, R., Purdie, D. M., Reynolds, P., Stram, D., West, D., Wright, W. E., Ziogas, A., & Ross, R. K. (2005). Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status. Journal of the National Cancer Institute., 97: 805–812.
[3]. Chen H, Jacobs E, Schwarzschild M et al. (2005) Nonsteroidal antiinflammatory drug use and the risk for Parkinson’s disease. Ann Neurol ;58:963–967.
[4]. Vlad, S. C., Miller, D. R., Kowall, N. W., & Felson, D. T. (2008) Protective effects of NSAIDs on the development of Alzheimer disease. Neurology., 70: 1672–1677.
[5]. Sondergaard, K. B., Weeke, P., Wissenberg, M., Olsen, A. S., Fosbol, E. L., Lippert, F. K., Torp-Pedersen, C., Gislason, G. H., & Folke, F. (2016) Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case-time-control study. European Heart Journal-Cardiovascular Pharmacotherapy., 356:100–107.
[6]. DrugBank Online. Ibuprofen: Uses, interactions, mechanism of action. https://go.drugbank.com/drugs/DB01050
[7]. Zeng, Y., Wang, Y., Liang, Z., & Jiao, Z. (2020) The study of chiral recognition on ibuprofen enantiomers by a fluorescent probe based on β-cyclodextrin modified ZnS: Mn quantum dots. https://doi.org/10.1016/j.saa.2020.119002
[8]. Ricciotti, E, & FitzGerald, G. A. (2011) Prostaglandins and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology., 31: 986–1000.
[9]. Encyclopedia Britannica. (2024) Prostaglandin | Definition, Function, Synthesis, & Facts. https://www.britannica.com/science/prostaglandin
[10]. Mediators of Inflammation. (2012) PGI2 as a regulator of inflammatory diseases. https://pubmed.ncbi.nlm.nih.gov/22851816/
[11]. BMC Veterinary Research. (2019). Prostaglandin F2α (PGF2α) production possibility and its receptors expression in the early- and late cleavedpreimplantation bovine embryos. https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-019-1939-0
[12]. Wang, J, Liu, M, Zhang, X, Yang, G, & Chen, L.(2018) Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney. Prostaglandins & Other Lipid Mediators., 134: 1- 6.
[13]. PubMed. (2024) Physiology, Thromboxane A2. https://pubmed.ncbi.nlm.nih.gov/30969639/
[14]. Mediators of Inflammation. (2012) PGD synthase and PGD2 in immune response. https://doi.org/10.1155/2012/503128
[15]. Karim, S. M. M., Sandler, M., & Williams, E. D. (1967) Distribution of prostaglandins in human tissues. British Journal of Pharmacology and Chemotherapy., 31: 340–344
[16]. Blobaum, A. L., & Marnett, L. J. (2007) Structural and functional basis of cyclooxygenase inhibition. Journal of Medicinal Chemistry., 50: 1425–1441.
[17]. Mazaleuskaya, L. L., Theken, K. N., Gong, L., Thorn, C. F., FitzGerald, G. A., Altman, R. B., & Klein, T. E. (2014) PharmGKB summary. Pharmacogenetics and Genomics., 23: 96–106.