Volume 99

Catechol is a pollutant commonly found in industrial and everyday wastewater, with genotoxic effects that can lead to mutations, DNA fragmentation, and chromosomal aberrations. Traditional physical and chemical degradation methods face challenges such as high costs and secondary pollution, whereas biological degradation offers a cost-effective and ...

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Chronic myelogenous leukemia (CML) and non-small cell lung cancer (NSCLC) are two common malignant tumors. Traditional treatments mainly include chemotherapy, radiotherapy, and bone marrow transplantation for CML. However, the low success rate of donor matching limits the widespread use of bone marrow transplants. The development of tumors is close...

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Dysmenorrhea significantly impacts the quality of life and health of many women worldwide, with primary dysmenorrhea being a major component. Primary dysmenorrhea is primarily driven by the excessive production of prostaglandins, which are responsible for regulating uterine contractions and the shedding of the endometrium. While prostaglandins are ...

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SARS-CoV-2, the causative agent of COVID-19, represents a significant global health challenge. The continuous emergence of variants with immune-evasion capabilities, particularly Delta, Beta, and Omicron, has raised concerns about the long-term efficacy of current vaccines. These variants harbor mutations in the spike protein that alter viral bindi...

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Nowadays, childhood obesity has become an increasingly significant public health challenge, particularly in developed urban environments. In order to have a better understanding of this heated topic, this study investigates the obesity rate of children in London by analyzing its spatial and temporal trends. Besides, the research uses multiple linea...

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Breast cancer is a heterogeneous malignancy that consists of multiple molecular subtypes, each requiring therapeutic approaches distinctively. While traditional treatments, including endocrine therapy, and anti-HER2 therapy, primarily targeting on cancer cell proliferation and survival, emerging evidence underscores their profound immunomodulatory ...

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With the development of technology, although it has become easier to detect and treat oral cancer, it still causes significant harm to people’s lives. Therefore, it is urgent for researchers to clarify the mechanisms behind oral cancer and identify early detection signatures. Previous research has shown a connection between bacteria and the occurre...

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Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and a leading cause of cancer-related mortality in women. The incidence of TNBC is particularly high in China, yet treatment options remain limited, with chemotherapy—often associated with severe side effects—being the primary therapeutic approach. This study inves...

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Permeation properties of biofilms have been the theme and hotspot of natural medicinal chemistry research. Ginsenoside is the main active ingredient of ginseng and a membrane active compound that has been used as a drug and surfactant for a long time. The unique amphiphilic structure of ginsenoside determines that it has a hydrophobic triterpene or...

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In this study, an XGBoost model optimized based on the Newton-Raphson algorithm is proposed for the task of kidney stone risk prediction, which improves the parameter updating strategy of the traditional gradient boosting framework by introducing second-order derivative information. In order to verify the effectiveness of the model, the performance...

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